Diffuse Intrinsic Pontine Glioma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-04-24Clinical Trial Update: Exploratory Study of Effects of Radiation Therapy in Pediatric Patients With Central Nervous System Tumors
An exploratory study evaluating the effects of radiation therapy in pediatric patients with central nervous system tumors; the study include…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant [Phase 2]
Phase 2 clinical trial exploring ribociclib with everolimus or with temozolomide for high-grade gliomas and related diffuse gliomas; recruit…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG) [Phase 1, Phase 2]
This clinical trial assesses selinexor with radiation therapy for newly diagnosed diffuse intrinsic pontine glioma and high-grade glioma, in…
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CLINICAL_TRIALS trial_result · 2026-04-21Clinical Trial Update: Blood Brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Doxorubicin for Treatment of Pediatric DIPG [Phase 1, Phase 2]
A Phase 1/2 clinical trial update exploring blood-brain barrier disruption with Exablate focused ultrasound to deliver doxorubicin for pedia…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: Blood Brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Doxorubicin for Treatment of Pediatric Diffuse Intrinsic Pontine Gliomas (DIPG) [Phase 1, Phase 2]
Phase 1/2 clinical trial evaluating blood-brain barrier disruption with Exablate focused ultrasound to enhance delivery of doxorubicin for p…
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CLINICAL_TRIALS trial_result · 2026-04-15Clinical Trial Update: HRQL and Symptom Assessment for Patients With DIPG or Recurrent and Re-irradiated Brain Tumours and Their Caregivers
A completed clinical trial evaluating health-related quality of life and symptoms in children with DIPG or recurrent/re-irradiated brain tum…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: Study in Children and Adolescents of 177Lu-DOTATATE (Lutathera®) Combined With the PARP Inhibitor Olaparib for the Treatment of Recurrent or Relapsed Solid Tumours Expressing Somatostatin Receptor (SSTR) (LuPARPed). [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating Lutathera (177Lu-DOTATATE) in combination with Olaparib for somatostatin receptor–expressing recurrent…
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CLINICAL_TRIALS trial_result · 2026-04-13Clinical Trial Update: Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors [Phase 1]
Phase 1 clinical trial evaluating B7-H3–specific CAR T cell therapy delivered locoregionally for diffuse intrinsic pontine glioma/diffuse mi…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating Lutathera (lutetium-177 dotatate) for recurrent or progressive high-grade central nervous system tumor…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas [Phase 1, Phase 2]
Clinical trial update reports ongoing Phase 1/Phase 2 testing of eflornithine (DFMO) with AMXT 1501 for neuroblastoma, CNS tumors, and sarco…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas, Diffuse Intrinsic Pontine Gliomas, Hypermutated Brain Tumors, Ependymoma or Medulloblastoma [Phase 1]
Phase 1 trial of pembrolizumab in pediatric patients with recurrent or refractory high-grade gliomas, including diffuse intrinsic pontine gl…
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: Study of Tovorafenib in High-Grade Glioma and Diffuse Intrinsic Pontine Glioma (DIPG) [Phase 2]
Phase 2 study of tovorafenib for high-grade glioma with BRAF aberration and diffuse intrinsic pontine glioma; the trial is not yet recruitin…
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma [Phase 2]
Phase 2 clinical trial of the PEP-CMV CMV antigen-targeted vaccine for newly diagnosed pediatric high-grade glioma, diffuse intrinsic pontin…
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CLINICAL_TRIALS research · 2026-04-06Clinical Trial Update: A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma [Phase 1]
A Phase 1 pediatric trial of SurVaxM for progressive or relapsed medulloblastoma, high-grade glioma, ependymoma, and newly diagnosed diffuse…
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CLINICAL_TRIALS trial_result · 2026-04-06Clinical Trial Update: Optune for Children With High-Grade Glioma or Ependymoma, and Optune With Radiation Therapy for Children With DIPG [NA]
This ClinicalTrials.gov entry reports ongoing pediatric trials of Optune (Tumor Treating Fields) for malignant glioma and ependymoma, and in…
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CLINICAL_TRIALS research · 2026-03-31Clinical Trial Update: Targeted Pediatric High-Grade Glioma Therapy
A pediatric clinical trial is currently recruiting to evaluate a targeted therapy for high-grade gliomas, including diffuse intrinsic pontin…
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CLINICAL_TRIALS trial_result · 2026-03-30Clinical Trial Update: H3K27M-specific Immune Effector Cells Targeting DMG/DIPG [Phase 1, Phase 2]
A Phase 1/2 clinical trial of H3K27M-targeted immune effector cells for diffuse midline glioma and DIPG is currently recruiting.
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: A Phase 1b Study of PTC596 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma and High Grade Glioma [Phase 1]
Phase 1b study of the investigational drug PTC596 in children with newly diagnosed diffuse intrinsic pontine glioma and high-grade glioma; t…
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: ACT001 for the Treatment of Diffuse Intrinsic Pontine Gliomas and H3K27-altered High Grade Gliomas [Phase 2]
This clinical trial update describes a Phase 2 study of ACT001 for diffuse intrinsic pontine glioma and H3K27-altered diffuse midline glioma…
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CLINICAL_TRIALS research · 2026-03-18Clinical Trial Update: Dose Escalation Study of CLR 131 in Pediatric Relapsed/Refractory Malignant Tumors Including Neuroblastoma and Sarcomas [Phase 1]
Phase 1 dose-escalation study of CLR-131 in children with relapsed or refractory malignant tumors, including neuroblastoma and sarcomas, cur…
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CLINICAL_TRIALS trial_result · 2026-03-18Clinical Trial Update: A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion [EARLY_Phase 1]
A pilot Phase 1 trial evaluating larotrectinib for newly diagnosed high-grade glioma with NTRK gene fusions, including diffuse intrinsic pon…
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CLINICAL_TRIALS research · 2026-03-17Clinical Trial Update: rHSC-DIPGVax Plus Checkpoint Blockade for the Treatment of Newly Diagnosed DIPG and DMG [Phase 1]
This Phase 1 study evaluates rHSC-DIPGVax in combination with checkpoint blockade for newly diagnosed diffuse intrinsic pontine glioma and d…
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CLINICAL_TRIALS trial_result · 2026-03-16Clinical Trial Update: Cilengitide in Combination With Irradiation in Children With Diffuse Intrinsic Pontine Glioma [Phase 1]
A Phase 1 trial evaluating cilengitide with irradiation in pediatric patients with diffuse intrinsic pontine glioma has completed.
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion [EARLY_Phase 1]
A Phase 1 study assessing lorlatinib for newly diagnosed high-grade gliomas with ALK or ROS1 fusions; currently recruiting.
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: Testing the Addition of an Anti-Cancer Drug, AZD1390, During Radiation Therapy for Newly Diagnosed High Grade Glioma, Diffuse Midline Glioma, or Diffuse Intrinsic Pontine Glioma [Phase 1]
A Phase 1 trial evaluating the addition of AZD1390 to radiation therapy for newly diagnosed pediatric high-grade gliomas, including diffuse …