Diffuse Intrinsic Pontine Glioma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant [Phase 2]
Phase 2 clinical trial exploring ribociclib with everolimus or with temozolomide for high-grade gliomas and related diffuse gliomas; recruit…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG) [Phase 1, Phase 2]
This clinical trial assesses selinexor with radiation therapy for newly diagnosed diffuse intrinsic pontine glioma and high-grade glioma, in…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: Blood Brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Doxorubicin for Treatment of Pediatric Diffuse Intrinsic Pontine Gliomas (DIPG) [Phase 1, Phase 2]
Phase 1/2 clinical trial evaluating blood-brain barrier disruption with Exablate focused ultrasound to enhance delivery of doxorubicin for p…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: Study in Children and Adolescents of 177Lu-DOTATATE (Lutathera®) Combined With the PARP Inhibitor Olaparib for the Treatment of Recurrent or Relapsed Solid Tumours Expressing Somatostatin Receptor (SSTR) (LuPARPed). [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating Lutathera (177Lu-DOTATATE) in combination with Olaparib for somatostatin receptor–expressing recurrent…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating Lutathera (lutetium-177 dotatate) for recurrent or progressive high-grade central nervous system tumor…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas [Phase 1, Phase 2]
Clinical trial update reports ongoing Phase 1/Phase 2 testing of eflornithine (DFMO) with AMXT 1501 for neuroblastoma, CNS tumors, and sarco…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas, Diffuse Intrinsic Pontine Gliomas, Hypermutated Brain Tumors, Ependymoma or Medulloblastoma [Phase 1]
Phase 1 trial of pembrolizumab in pediatric patients with recurrent or refractory high-grade gliomas, including diffuse intrinsic pontine gl…
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: Study of Tovorafenib in High-Grade Glioma and Diffuse Intrinsic Pontine Glioma (DIPG) [Phase 2]
Phase 2 study of tovorafenib for high-grade glioma with BRAF aberration and diffuse intrinsic pontine glioma; the trial is not yet recruitin…
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma [Phase 2]
Phase 2 clinical trial of the PEP-CMV CMV antigen-targeted vaccine for newly diagnosed pediatric high-grade glioma, diffuse intrinsic pontin…
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CLINICAL_TRIALS research · 2026-04-06Clinical Trial Update: A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma [Phase 1]
A Phase 1 pediatric trial of SurVaxM for progressive or relapsed medulloblastoma, high-grade glioma, ependymoma, and newly diagnosed diffuse…
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CLINICAL_TRIALS research · 2026-03-31Clinical Trial Update: Targeted Pediatric High-Grade Glioma Therapy
A pediatric clinical trial is currently recruiting to evaluate a targeted therapy for high-grade gliomas, including diffuse intrinsic pontin…
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: A Phase 1b Study of PTC596 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma and High Grade Glioma [Phase 1]
Phase 1b study of the investigational drug PTC596 in children with newly diagnosed diffuse intrinsic pontine glioma and high-grade glioma; t…
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: ACT001 for the Treatment of Diffuse Intrinsic Pontine Gliomas and H3K27-altered High Grade Gliomas [Phase 2]
This clinical trial update describes a Phase 2 study of ACT001 for diffuse intrinsic pontine glioma and H3K27-altered diffuse midline glioma…
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CLINICAL_TRIALS research · 2026-03-18Clinical Trial Update: Dose Escalation Study of CLR 131 in Pediatric Relapsed/Refractory Malignant Tumors Including Neuroblastoma and Sarcomas [Phase 1]
Phase 1 dose-escalation study of CLR-131 in children with relapsed or refractory malignant tumors, including neuroblastoma and sarcomas, cur…
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CLINICAL_TRIALS research · 2026-03-17Clinical Trial Update: rHSC-DIPGVax Plus Checkpoint Blockade for the Treatment of Newly Diagnosed DIPG and DMG [Phase 1]
This Phase 1 study evaluates rHSC-DIPGVax in combination with checkpoint blockade for newly diagnosed diffuse intrinsic pontine glioma and d…
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion [EARLY_Phase 1]
A Phase 1 study assessing lorlatinib for newly diagnosed high-grade gliomas with ALK or ROS1 fusions; currently recruiting.
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: Testing the Addition of an Anti-Cancer Drug, AZD1390, During Radiation Therapy for Newly Diagnosed High Grade Glioma, Diffuse Midline Glioma, or Diffuse Intrinsic Pontine Glioma [Phase 1]
A Phase 1 trial evaluating the addition of AZD1390 to radiation therapy for newly diagnosed pediatric high-grade gliomas, including diffuse …
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CLINICAL_TRIALS research · 2026-03-09Clinical Trial Update: PEACH TRIAL- Precision Medicine and Adoptive Cellular Therapy [Phase 1]
Clinical trial update for the Phase 1 PEACH trial (precision medicine and adoptive cellular therapy) for neuroblastoma and diffuse intrinsic…
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CLINICAL_TRIALS research · 2026-02-05Clinical Trial Update: Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication 2.0 [Phase 3]
A Phase 3 clinical trial evaluating a biological medicine for diffuse intrinsic pontine glioma and related diffuse midline gliomas is curren…
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CLINICAL_TRIALS research · 2026-01-28Clinical Trial Update: FUS Etoposide for DMG [Phase 1]
Phase 1 trial investigating focused ultrasound-delivered etoposide for diffuse intrinsic pontine glioma and H3 K27M-mutant diffuse midline g…
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CLINICAL_TRIALS research · 2026-01-26Clinical Trial Update: GD2 CAR T Cells in Diffuse Intrinsic Pontine Gliomas (DIPG) & Spinal Diffuse Midline Glioma(DMG) [Phase 1]
A Phase 1 clinical trial is evaluating GD2 CAR T cells for diffuse intrinsic pontine glioma and spinal diffuse midline glioma, and the study…
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CLINICAL_TRIALS research · 2026-01-09Clinical Trial Update: Gallium Maltolate for the Treatment of Pediatric Patients With Relapsed or Refractory Pediatric High-Grade Glioma and Atypical Teratoid Rhabdoid Tumor [Phase 1]
This clinical trial update describes a Phase 1 study of gallium maltolate for relapsed or refractory pediatric high-grade glioma and atypica…
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CLINICAL_TRIALS research · 2025-12-17Clinical Trial Update: Combination Therapy for the Treatment of Diffuse Midline Gliomas [Phase 2]
A Phase 2 clinical trial update describes a combination therapy for diffuse midline gliomas, including H3 K27M-mutant DMG and DIPG, with the…
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CLINICAL_TRIALS research · 2025-12-08Clinical Trial Update: Treatment of Relapsed/Refractory Intracranial Glioma in Patients Under 22 Years of Age [Phase 1, Phase 2]
A Phase 1/2 clinical trial update for relapsed/refractory intracranial glioma in patients under 22 years, currently recruiting.
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CLINICAL_TRIALS research · 2025-11-20Clinical Trial Update: Study of B7-H3, EGFR806, HER2, And IL13-Zetakine (Quad) CAR T Cell Locoregional Immunotherapy For Pediatric Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, And Recurrent Or Refractory Central Nervous System Tumors [Phase 1]
This Phase 1 clinical trial update describes a Quad CAR T cell therapy targeting B7-H3, EGFR806, HER2, and IL13-Zetakine for pediatric diffu…