Diffuse Intrinsic Pontine Glioma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-03-09Clinical Trial Update: PEACH TRIAL- Precision Medicine and Adoptive Cellular Therapy [Phase 1]
Clinical trial update for the Phase 1 PEACH trial (precision medicine and adoptive cellular therapy) for neuroblastoma and diffuse intrinsic…
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CLINICAL_TRIALS research · 2026-02-05Clinical Trial Update: Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication 2.0 [Phase 3]
A Phase 3 clinical trial evaluating a biological medicine for diffuse intrinsic pontine glioma and related diffuse midline gliomas is curren…
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CLINICAL_TRIALS research · 2026-01-28Clinical Trial Update: FUS Etoposide for DMG [Phase 1]
Phase 1 trial investigating focused ultrasound-delivered etoposide for diffuse intrinsic pontine glioma and H3 K27M-mutant diffuse midline g…
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CLINICAL_TRIALS research · 2026-01-26Clinical Trial Update: GD2 CAR T Cells in Diffuse Intrinsic Pontine Gliomas (DIPG) & Spinal Diffuse Midline Glioma(DMG) [Phase 1]
A Phase 1 clinical trial is evaluating GD2 CAR T cells for diffuse intrinsic pontine glioma and spinal diffuse midline glioma, and the study…
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CLINICAL_TRIALS research · 2026-01-09Clinical Trial Update: Gallium Maltolate for the Treatment of Pediatric Patients With Relapsed or Refractory Pediatric High-Grade Glioma and Atypical Teratoid Rhabdoid Tumor [Phase 1]
This clinical trial update describes a Phase 1 study of gallium maltolate for relapsed or refractory pediatric high-grade glioma and atypica…
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CLINICAL_TRIALS trial_result · 2026-01-08Clinical Trial Update: Pediatric Trial of Indoximod With Chemotherapy and Radiation for Relapsed Brain Tumors or Newly Diagnosed DIPG [Phase 2]
Phase 2 pediatric trial evaluating indoximod with chemotherapy and radiation for relapsed brain tumors or newly diagnosed diffuse intrinsic …
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CLINICAL_TRIALS research · 2025-12-17Clinical Trial Update: Combination Therapy for the Treatment of Diffuse Midline Gliomas [Phase 2]
A Phase 2 clinical trial update describes a combination therapy for diffuse midline gliomas, including H3 K27M-mutant DMG and DIPG, with the…
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CLINICAL_TRIALS research · 2025-12-08Clinical Trial Update: Treatment of Relapsed/Refractory Intracranial Glioma in Patients Under 22 Years of Age [Phase 1, Phase 2]
A Phase 1/2 clinical trial update for relapsed/refractory intracranial glioma in patients under 22 years, currently recruiting.
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CLINICAL_TRIALS research · 2025-11-20Clinical Trial Update: Study of B7-H3, EGFR806, HER2, And IL13-Zetakine (Quad) CAR T Cell Locoregional Immunotherapy For Pediatric Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, And Recurrent Or Refractory Central Nervous System Tumors [Phase 1]
This Phase 1 clinical trial update describes a Quad CAR T cell therapy targeting B7-H3, EGFR806, HER2, and IL13-Zetakine for pediatric diffu…
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CLINICAL_TRIALS trial_result · 2025-11-12Clinical Trial Update: A Study of Cobolimab Plus Dostarlimab in Pediatric and Young Adult Participants With Cancer [Phase 1, Phase 2]
This document details an ongoing Phase 1/2 clinical trial evaluating cobolimab in combination with dostarlimab in pediatric and young adult …
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CLINICAL_TRIALS trial_result · 2025-10-29Clinical Trial Update: Brain Stem Gliomas Treated With Adoptive Cellular Therapy During Focal Radiotherapy Recovery Alone or With Dose-intensified Temozolomide (Phase I) [Phase 1]
Phase I trial evaluating adoptive cellular therapy during focal radiotherapy, with or without dose-intensified temozolomide, for diffuse int…
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CLINICAL_TRIALS research · 2025-10-20Clinical Trial Update: International Diffuse Intrinsic Pontine Glioma (DIPG)/Diffuse Midline Glioma (DMG) Registry and Repository
An international DIPG/DMG Registry and Repository study is currently recruiting to collect data and biospecimens for diffuse intrinsic ponti…
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CLINICAL_TRIALS research · 2025-09-19Clinical Trial Update: Effect of Antineoplaston Therapy on the QT/QTc Interval In Subjects With Diffuse, Intrinsic, Brainstem Glioma [Phase 3]
Phase 3 trial evaluating the effect of antineoplaston therapy on QT/QTc interval in patients with diffuse intrinsic pontine glioma.
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CLINICAL_TRIALS other · 2025-09-16Clinical Trial Update: Study of Antineoplaston Therapy + Radiation vs. Radiation Only in Diffuse, Intrinsic, Brainstem Glioma [Phase 3]
Clinical trial update indicates a Phase 3 study of antineoplaston therapy plus radiation versus radiation only for diffuse intrinsic pontine…
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CLINICAL_TRIALS trial_result · 2025-09-16Clinical Trial Update: A Study of Atengenal and Astugenal in Diffuse, Intrinsic Pontine Glioma (DIPG) [Phase 2]
A Phase 2 study evaluating Atengenal and Astugenal for diffuse intrinsic pontine glioma has been suspended.
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CLINICAL_TRIALS research · 2025-09-04Clinical Trial Update: C7R-GD2.CAR T Cells for Patients With GD2-expressing Brain Tumors (GAIL-B) [Phase 1]
Phase 1 clinical trial update for C7R-GD2.CAR T cells targeting GD2-expressing brain tumors, currently recruiting for DIPG, high-grade gliom…
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CLINICAL_TRIALS trial_result · 2025-08-12Clinical Trial Update: A Study of Ad-RTS-hIL-12 + Veledimex in Pediatric Subjects With Brain Tumors Including DIPG [Phase 1, Phase 2]
The Phase 1/2 study of Ad-RTS-hIL-12 plus Veledimex in pediatric brain tumors including diffuse intrinsic pontine glioma was terminated, and…
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CLINICAL_TRIALS research · 2025-07-22Clinical Trial Update: Atovaquone Combined With Radiation in Children With Malignant Brain Tumors [Phase 1]
A Phase 1 clinical trial evaluating atovaquone in combination with radiation for pediatric malignant brain tumors is currently recruiting.
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CLINICAL_TRIALS trial_result · 2025-07-17Clinical Trial Update: 9-ING-41 in Pediatric Patients With Refractory Malignancies. [Phase 1]
Phase 1 trial of 9-ING-41 in pediatric patients with refractory malignancies was terminated; the update does not include study results.
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CLINICAL_TRIALS research · 2025-07-11Clinical Trial Update: Fimepinostat in Treating Brain Tumors in Children and Young Adults [EARLY_Phase 1]
This is an early-phase 1 trial update on fimepinostat for pediatric and young adult brain tumors, including DIPG, recurrent anaplastic astro…
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CLINICAL_TRIALS trial_result · 2025-06-08Clinical Trial Update: Non-Invasive Focused Ultrasound (FUS) With Oral Panobinostat in Children With Progressive Diffuse Midline Glioma (DMG) [Phase 1]
A Phase 1 trial evaluating non-invasive focused ultrasound in combination with oral panobinostat for children with progressive diffuse midli…
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CLINICAL_TRIALS trial_result · 2025-06-06Clinical Trial Update: Neoantigen Vaccine Therapy Against H3.3-K27M Diffuse Intrinsic Pontine Glioma [Phase 1]
Phase 1 trial evaluating a neoantigen vaccine therapy for Diffuse Intrinsic Pontine Glioma (H3.3-K27M) has completed.
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CLINICAL_TRIALS trial_result · 2025-04-20Clinical Trial Update: Volitinib in Treating Patients With Recurrent or Refractory Primary CNS Tumors [Phase 1]
Volitinib is being studied in a Phase 1 trial for patients with recurrent or refractory primary CNS tumors, with the study currently listed …
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CLINICAL_TRIALS research · 2025-04-11Clinical Trial Update: A Study of Low Dose Bevacizumab With Conventional Radiotherapy Alone in Diffuse Intrinsic Pontine Glioma [Phase 2]
A Phase 2 clinical trial is investigating low-dose bevacizumab with conventional radiotherapy for diffuse intrinsic pontine glioma. The stud…
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CLINICAL_TRIALS trial_result · 2025-04-02Clinical Trial Update: Vorinostat and Temsirolimus With or Without Radiation Therapy in Treating Younger Patients With Newly Diagnosed or Progressive Diffuse Intrinsic Pontine Glioma [Phase 1]
Phase 1 trial evaluating vorinostat and temsirolimus with or without radiation therapy in younger patients with newly diagnosed or progressi…