Clinical Trial Update: Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant [Phase 2]

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Summary

Phase 2 clinical trial exploring ribociclib with everolimus or with temozolomide for high-grade gliomas and related diffuse gliomas; recruitment is ongoing.

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Diseases / indications

• Anaplastic Astrocytoma
• Diffuse Hemispheric Glioma H3 G34-mutant
• Diffuse Intrinsic Pontine Glioma
• Diffuse Midline Glioma H3 K27m-mutant
• Glioblastoma
• High-grade Glioma
• Who Grade Iii Glioma
• Who Grade Iv Glioma

Drugs mentioned

• Everolimus (everolimus)
• Ribociclib (ribociclib)
• Temozolomide (Temozolomide)

Snippet

Sponsor: Nationwide Children's Hospital | Conditions: High Grade Glioma, Diffuse Intrinsic Pontine Glioma | Phase 2 | Status: RECRUITING