Diffuse Intrinsic Pontine Glioma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-04-24Clinical Trial Update: Exploratory Study of Effects of Radiation Therapy in Pediatric Patients With Central Nervous System Tumors
An exploratory study evaluating the effects of radiation therapy in pediatric patients with central nervous system tumors; the study include…
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CLINICAL_TRIALS trial_result · 2026-04-21Clinical Trial Update: Blood Brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Doxorubicin for Treatment of Pediatric DIPG [Phase 1, Phase 2]
A Phase 1/2 clinical trial update exploring blood-brain barrier disruption with Exablate focused ultrasound to deliver doxorubicin for pedia…
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CLINICAL_TRIALS trial_result · 2026-04-15Clinical Trial Update: HRQL and Symptom Assessment for Patients With DIPG or Recurrent and Re-irradiated Brain Tumours and Their Caregivers
A completed clinical trial evaluating health-related quality of life and symptoms in children with DIPG or recurrent/re-irradiated brain tum…
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CLINICAL_TRIALS trial_result · 2026-04-13Clinical Trial Update: Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors [Phase 1]
Phase 1 clinical trial evaluating B7-H3–specific CAR T cell therapy delivered locoregionally for diffuse intrinsic pontine glioma/diffuse mi…
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CLINICAL_TRIALS trial_result · 2026-04-06Clinical Trial Update: Optune for Children With High-Grade Glioma or Ependymoma, and Optune With Radiation Therapy for Children With DIPG [NA]
This ClinicalTrials.gov entry reports ongoing pediatric trials of Optune (Tumor Treating Fields) for malignant glioma and ependymoma, and in…
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CLINICAL_TRIALS trial_result · 2026-03-30Clinical Trial Update: H3K27M-specific Immune Effector Cells Targeting DMG/DIPG [Phase 1, Phase 2]
A Phase 1/2 clinical trial of H3K27M-targeted immune effector cells for diffuse midline glioma and DIPG is currently recruiting.
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CLINICAL_TRIALS trial_result · 2026-03-18Clinical Trial Update: A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion [EARLY_Phase 1]
A pilot Phase 1 trial evaluating larotrectinib for newly diagnosed high-grade glioma with NTRK gene fusions, including diffuse intrinsic pon…
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CLINICAL_TRIALS trial_result · 2026-03-16Clinical Trial Update: Cilengitide in Combination With Irradiation in Children With Diffuse Intrinsic Pontine Glioma [Phase 1]
A Phase 1 trial evaluating cilengitide with irradiation in pediatric patients with diffuse intrinsic pontine glioma has completed.
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CLINICAL_TRIALS trial_result · 2026-01-08Clinical Trial Update: Pediatric Trial of Indoximod With Chemotherapy and Radiation for Relapsed Brain Tumors or Newly Diagnosed DIPG [Phase 2]
Phase 2 pediatric trial evaluating indoximod with chemotherapy and radiation for relapsed brain tumors or newly diagnosed diffuse intrinsic …
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CLINICAL_TRIALS trial_result · 2025-11-12Clinical Trial Update: A Study of Cobolimab Plus Dostarlimab in Pediatric and Young Adult Participants With Cancer [Phase 1, Phase 2]
This document details an ongoing Phase 1/2 clinical trial evaluating cobolimab in combination with dostarlimab in pediatric and young adult …
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CLINICAL_TRIALS trial_result · 2025-10-29Clinical Trial Update: Brain Stem Gliomas Treated With Adoptive Cellular Therapy During Focal Radiotherapy Recovery Alone or With Dose-intensified Temozolomide (Phase I) [Phase 1]
Phase I trial evaluating adoptive cellular therapy during focal radiotherapy, with or without dose-intensified temozolomide, for diffuse int…
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CLINICAL_TRIALS trial_result · 2025-09-16Clinical Trial Update: A Study of Atengenal and Astugenal in Diffuse, Intrinsic Pontine Glioma (DIPG) [Phase 2]
A Phase 2 study evaluating Atengenal and Astugenal for diffuse intrinsic pontine glioma has been suspended.
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CLINICAL_TRIALS trial_result · 2025-08-12Clinical Trial Update: A Study of Ad-RTS-hIL-12 + Veledimex in Pediatric Subjects With Brain Tumors Including DIPG [Phase 1, Phase 2]
The Phase 1/2 study of Ad-RTS-hIL-12 plus Veledimex in pediatric brain tumors including diffuse intrinsic pontine glioma was terminated, and…
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CLINICAL_TRIALS trial_result · 2025-07-17Clinical Trial Update: 9-ING-41 in Pediatric Patients With Refractory Malignancies. [Phase 1]
Phase 1 trial of 9-ING-41 in pediatric patients with refractory malignancies was terminated; the update does not include study results.
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CLINICAL_TRIALS trial_result · 2025-06-08Clinical Trial Update: Non-Invasive Focused Ultrasound (FUS) With Oral Panobinostat in Children With Progressive Diffuse Midline Glioma (DMG) [Phase 1]
A Phase 1 trial evaluating non-invasive focused ultrasound in combination with oral panobinostat for children with progressive diffuse midli…
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CLINICAL_TRIALS trial_result · 2025-06-06Clinical Trial Update: Neoantigen Vaccine Therapy Against H3.3-K27M Diffuse Intrinsic Pontine Glioma [Phase 1]
Phase 1 trial evaluating a neoantigen vaccine therapy for Diffuse Intrinsic Pontine Glioma (H3.3-K27M) has completed.
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CLINICAL_TRIALS trial_result · 2025-04-20Clinical Trial Update: Volitinib in Treating Patients With Recurrent or Refractory Primary CNS Tumors [Phase 1]
Volitinib is being studied in a Phase 1 trial for patients with recurrent or refractory primary CNS tumors, with the study currently listed …
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CLINICAL_TRIALS trial_result · 2025-04-02Clinical Trial Update: Vorinostat and Temsirolimus With or Without Radiation Therapy in Treating Younger Patients With Newly Diagnosed or Progressive Diffuse Intrinsic Pontine Glioma [Phase 1]
Phase 1 trial evaluating vorinostat and temsirolimus with or without radiation therapy in younger patients with newly diagnosed or progressi…
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CLINICAL_TRIALS trial_result · 2025-03-07Clinical Trial Update: Gemcitabine in Newly-Diagnosed Diffuse Intrinsic Pontine Glioma [EARLY_Phase 1]
The Phase 1 trial evaluating gemcitabine in newly diagnosed Diffuse Intrinsic Pontine Glioma has completed. The study was sponsored by the U…
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CLINICAL_TRIALS trial_result · 2025-02-19Clinical Trial Update: INCB7839 in Treating Children With Recurrent/Progressive High-Grade Gliomas [Phase 1]
Phase 1 trial of INCB7839 in children with recurrent or progressive high-grade gliomas has completed and results have been posted.
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CLINICAL_TRIALS trial_result · 2025-02-14Clinical Trial Update: ONC201 in Pediatric H3 K27M Gliomas [Phase 1]
Phase 1 trial update of ONC201 in pediatric H3 K27M gliomas including Diffuse Intrinsic Pontine Glioma and malignant glioma has been termina…
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CLINICAL_TRIALS trial_result · 2025-01-22Clinical Trial Update: H3.3K27M Peptide Vaccine With Nivolumab for Children With Newly Diagnosed DIPG and Other Gliomas [Phase 1, Phase 2]
Clinical trial results update for a combined H3.3K27M peptide vaccine and nivolumab in children with newly diagnosed Diffuse Intrinsic Ponti…
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CLINICAL_TRIALS trial_result · 2024-12-24Clinical Trial Update: Oral AMXT 1501 Dicaprate in Combination With IV DFMO [Phase 1, Phase 2]
A Phase 1/2 trial of oral AMXT 1501 dicaprate in combination with IV DFMO has been terminated.
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CLINICAL_TRIALS trial_result · 2024-12-20Clinical Trial Update: A Study of BXQ-350 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) or Diffuse Midline Glioma (DMG) [Phase 1]
Phase 1 trial evaluating BXQ-350 in children with newly diagnosed diffuse intrinsic pontine glioma and diffuse midline glioma (H3 K27M-mutan…
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CLINICAL_TRIALS trial_result · 2024-12-06Clinical Trial Update: A Pilot Study of Glioma Associated Antigen Vaccines in Conjunction with Poly-ICLC in Pediatric Gliomas [Phase 1]
This Phase 1 pilot trial evaluated glioma-associated antigen vaccines with the Toll-like receptor 3 agonist Poly-ICLC in pediatric gliomas a…