Atypical Teratoid Rhabdoid Tumor
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: Testing Cerebrospinal Fluid for Cell-free Tumor DNA in Children, Adolescents, and Young Adults With Brain Tumors
This trial update describes a pediatric brain tumor study using cerebrospinal fluid cell-free tumor DNA; the study was terminated.
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CLINICAL_TRIALS trial_result · 2026-04-13Clinical Trial Update: Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors [Phase 1]
Phase 1 clinical trial evaluating B7-H3–specific CAR T cell therapy delivered locoregionally for diffuse intrinsic pontine glioma/diffuse mi…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Tazemetostat+Nivo/Ipi in INI1-Neg/SMARCA4-Def Tumors [Phase 1, Phase 2]
A clinical trial update on a Phase 1/2 study of combining tazemetostat with nivolumab and ipilimumab in INI1/SMARCB1-deficient and SMARCA4-d…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas [Phase 1, Phase 2]
Clinical trial update reports ongoing Phase 1/Phase 2 testing of eflornithine (DFMO) with AMXT 1501 for neuroblastoma, CNS tumors, and sarco…
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CLINICAL_TRIALS trial_result · 2026-04-13Clinical Trial Update: Tiragolumab and Atezolizumab for the Treatment of Relapsed or Refractory SMARCB1 or SMARCA4 Deficient Tumors [Phase 1, Phase 2]
Clinical trial update of a tiragolumab plus atezolizumab combination for relapsed or refractory SMARCB1/SMARCA4-deficient tumors, spanning P…
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CLINICAL_TRIALS trial_result · 2026-04-07Clinical Trial Update: GPC3 CAR T Cells With IL-15 and IL-21 for Recurrent ATRT and CNS Rhabdoid Tumors (RADIANT) [Phase 1]
Phase 1 trial evaluating GPC3 CAR T cells with IL-15 and IL-21 for recurrent atypical teratoid rhabdoid tumor and CNS rhabdoid tumors; curre…
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CLINICAL_TRIALS trial_result · 2026-03-17Clinical Trial Update: Phase 2 Study of Alisertib Therapy for Rhabdoid Tumors [Phase 2]
An update on a Phase 2 trial of alisertib for malignant rhabdoid tumors and atypical teratoid rhabdoid tumors, with the study currently acti…
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CLINICAL_TRIALS research · 2026-03-10Clinical Trial Update: Immunotherapy for Malignant Pediatric Brain Tumors Employing Adoptive Cellular Therapy (IMPACT) [Phase 1]
This clinical trial update describes an ongoing Phase 1 study evaluating adoptive cellular therapy immunotherapy for several pediatric malig…
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CLINICAL_TRIALS research · 2026-03-03Clinical Trial Update: Study of Novel Therapies for Young People With Recurrent/Progressive Atypical Teratoid Rhabdoid Tumor (ATRT) [Phase 2]
A Phase 2 study evaluating novel therapies for pediatric atypical teratoid/rhabdoid tumor (ATRT) of the central nervous system is currently …
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post Consolidation [EARLY_Phase 1]
This is a pediatric early-phase 1 trial update evaluating intrathecal topotecan with maintenance chemotherapy for high-risk embryonal centra…
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CLINICAL_TRIALS research · 2026-02-23Clinical Trial Update: Antiangiogenic Therapy for Children With Recurrent Medulloblastoma, Ependymoma, ATRT and Rare CNS Tumors [Phase 2]
A Phase 2 clinical trial update describes an antiangiogenic therapy for children with recurrent medulloblastoma, ependymoma, ATRT, and other…
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CLINICAL_TRIALS trial_result · 2026-02-20Clinical Trial Update: An Intermediate Expanded Use Trial of DFMO
This is an update on an intermediate expanded-use trial of DFMO for neuroblastoma and several embryonal CNS tumors, including medulloblastom…
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CLINICAL_TRIALS trial_result · 2026-02-05Clinical Trial Update: B7-H3.CD28Z.CART in CNS Neoplasms [Phase 1]
A Phase 1 clinical trial evaluating B7-H3.CD28Z.CART for central nervous system neoplasms is currently not yet recruiting.
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CLINICAL_TRIALS research · 2026-01-20Clinical Trial Update: Loc3CAR: Locoregional Delivery of B7-H3-CAR T Cells for Pediatric Patients With Primary CNS Tumors [Phase 1]
Clinical trial update indicating that Loc3CAR (B7-H3-CAR T cells) delivery is in early-phase pediatric CNS tumor trials and currently recrui…
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CLINICAL_TRIALS research · 2026-01-09Clinical Trial Update: Gallium Maltolate for the Treatment of Pediatric Patients With Relapsed or Refractory Pediatric High-Grade Glioma and Atypical Teratoid Rhabdoid Tumor [Phase 1]
This clinical trial update describes a Phase 1 study of gallium maltolate for relapsed or refractory pediatric high-grade glioma and atypica…
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CLINICAL_TRIALS research · 2025-12-17Clinical Trial Update: HER2-specific CAR T Cell Locoregional Immunotherapy for HER2-positive Recurrent/Refractory Pediatric CNS Tumors [Phase 1]
Phase 1 trial evaluating locoregional HER2-targeted CAR T-cell therapy for pediatric recurrent or refractory central nervous system tumors a…
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CLINICAL_TRIALS research · 2025-12-17Clinical Trial Update: Study of Nivolumab and Ipilimumab in Children and Young Adults With INI1-Negative Cancers [Phase 2]
This update describes a Phase 2 study of the combination of nivolumab and ipilimumab in children and young adults with INI1-negative cancers…
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CLINICAL_TRIALS trial_result · 2025-12-17Clinical Trial Update: EGFR806-specific CAR T Cell Locoregional Immunotherapy for EGFR-positive Recurrent or Refractory Pediatric CNS Tumors [Phase 1]
Phase 1 trial evaluating locoregional EGFR806-specific CAR T cells for EGFR-positive pediatric CNS tumors. The study status is completed.
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CLINICAL_TRIALS research · 2025-11-20Clinical Trial Update: Rhabdoid Tumors Cellular Architecture by Single-cell Analyses (InnovRT-2)
This clinical trial update notes the completion of the InnovRT-2 study investigating the cellular architecture of atypical teratoid/rhabdoid…
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CLINICAL_TRIALS trial_result · 2025-11-20Clinical Trial Update: Finding New Targets by Proteomic Approaches (InnovRT1)
This clinical trial update reports a completed study (InnovRT1) investigating proteomic approaches to identify new targets for atypical tera…
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CLINICAL_TRIALS research · 2025-06-17Clinical Trial Update: A Phase 0/1 Study of cDNA for TP53, Checkpoint Inhibition and Radiation in Children With Recurrent, Progressive or Refractory CNS Malignancies. [EARLY_Phase 1]
An early-phase trial evaluating TP53 cDNA gene therapy combined with checkpoint inhibition and radiation in children with recurrent or refra…
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CLINICAL_TRIALS trial_result · 2025-03-11Clinical Trial Update: A Study of Tazemetostat in Adult Participants With Soft Tissue Sarcoma [Phase 2]
Phase 2 study of tazemetostat in adult participants with soft tissue sarcoma, including rhabdoid tumors, has completed and results were post…
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CLINICAL_TRIALS trial_result · 2025-02-28Clinical Trial Update: Feasibility of Using Bortezomib With or Without Chemotherapy in Patients With Atypical Teratoid/Rhabdoid Tumors [Phase 2]
Phase 2 trial update evaluating the feasibility of adding bortezomib, with or without standard chemotherapy, in patients with atypical terat…
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CLINICAL_TRIALS trial_result · 2025-02-24Clinical Trial Update: A Study of Panobinostat in Pediatric Patients With Solid Tumors Including MRT/ATRT [Phase 2]
This is a Phase 2 clinical trial update for panobinostat in pediatric solid tumors including malignant rhabdoid tumor and atypical teratoid/…
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CLINICAL_TRIALS withdrawal · 2024-10-26Clinical Trial Update: Chemotherapy and Donor Stem Transplant for the Treatment of Patients With High Grade Brain Cancer [Phase 1]
A Phase 1 trial investigating chemotherapy and donor stem cell transplantation for high-grade brain cancers has been withdrawn. The study in…