Atypical Teratoid Rhabdoid Tumor
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: Testing Cerebrospinal Fluid for Cell-free Tumor DNA in Children, Adolescents, and Young Adults With Brain Tumors
This trial update describes a pediatric brain tumor study using cerebrospinal fluid cell-free tumor DNA; the study was terminated.
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Tazemetostat+Nivo/Ipi in INI1-Neg/SMARCA4-Def Tumors [Phase 1, Phase 2]
A clinical trial update on a Phase 1/2 study of combining tazemetostat with nivolumab and ipilimumab in INI1/SMARCB1-deficient and SMARCA4-d…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas [Phase 1, Phase 2]
Clinical trial update reports ongoing Phase 1/Phase 2 testing of eflornithine (DFMO) with AMXT 1501 for neuroblastoma, CNS tumors, and sarco…
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CLINICAL_TRIALS research · 2026-03-10Clinical Trial Update: Immunotherapy for Malignant Pediatric Brain Tumors Employing Adoptive Cellular Therapy (IMPACT) [Phase 1]
This clinical trial update describes an ongoing Phase 1 study evaluating adoptive cellular therapy immunotherapy for several pediatric malig…
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CLINICAL_TRIALS research · 2026-03-03Clinical Trial Update: Study of Novel Therapies for Young People With Recurrent/Progressive Atypical Teratoid Rhabdoid Tumor (ATRT) [Phase 2]
A Phase 2 study evaluating novel therapies for pediatric atypical teratoid/rhabdoid tumor (ATRT) of the central nervous system is currently …
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post Consolidation [EARLY_Phase 1]
This is a pediatric early-phase 1 trial update evaluating intrathecal topotecan with maintenance chemotherapy for high-risk embryonal centra…
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CLINICAL_TRIALS research · 2026-02-23Clinical Trial Update: Antiangiogenic Therapy for Children With Recurrent Medulloblastoma, Ependymoma, ATRT and Rare CNS Tumors [Phase 2]
A Phase 2 clinical trial update describes an antiangiogenic therapy for children with recurrent medulloblastoma, ependymoma, ATRT, and other…
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CLINICAL_TRIALS research · 2026-01-20Clinical Trial Update: Loc3CAR: Locoregional Delivery of B7-H3-CAR T Cells for Pediatric Patients With Primary CNS Tumors [Phase 1]
Clinical trial update indicating that Loc3CAR (B7-H3-CAR T cells) delivery is in early-phase pediatric CNS tumor trials and currently recrui…
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CLINICAL_TRIALS research · 2026-01-09Clinical Trial Update: Gallium Maltolate for the Treatment of Pediatric Patients With Relapsed or Refractory Pediatric High-Grade Glioma and Atypical Teratoid Rhabdoid Tumor [Phase 1]
This clinical trial update describes a Phase 1 study of gallium maltolate for relapsed or refractory pediatric high-grade glioma and atypica…
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CLINICAL_TRIALS research · 2025-12-17Clinical Trial Update: HER2-specific CAR T Cell Locoregional Immunotherapy for HER2-positive Recurrent/Refractory Pediatric CNS Tumors [Phase 1]
Phase 1 trial evaluating locoregional HER2-targeted CAR T-cell therapy for pediatric recurrent or refractory central nervous system tumors a…
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CLINICAL_TRIALS research · 2025-12-17Clinical Trial Update: Study of Nivolumab and Ipilimumab in Children and Young Adults With INI1-Negative Cancers [Phase 2]
This update describes a Phase 2 study of the combination of nivolumab and ipilimumab in children and young adults with INI1-negative cancers…
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CLINICAL_TRIALS research · 2025-11-20Clinical Trial Update: Rhabdoid Tumors Cellular Architecture by Single-cell Analyses (InnovRT-2)
This clinical trial update notes the completion of the InnovRT-2 study investigating the cellular architecture of atypical teratoid/rhabdoid…
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CLINICAL_TRIALS research · 2025-06-17Clinical Trial Update: A Phase 0/1 Study of cDNA for TP53, Checkpoint Inhibition and Radiation in Children With Recurrent, Progressive or Refractory CNS Malignancies. [EARLY_Phase 1]
An early-phase trial evaluating TP53 cDNA gene therapy combined with checkpoint inhibition and radiation in children with recurrent or refra…
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CLINICAL_TRIALS research · 2018-07-16Clinical Trial Update: Collecting and Storing Blood and Brain Tumor Tissue Samples From Children With Brain Tumors
This clinical trial update describes the collection and storage of blood and brain tumor tissue samples from children with brain tumors for …
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CLINICAL_TRIALS research · 2016-07-14Clinical Trial Update: Studying Gene Expression in Samples From Patients With Rhabdoid Tumors
Clinical trial update describing a study that analyzes gene expression in rhabdoid tumor samples from patients, including central nervous sy…