Clinical Trial Update: A Phase 0/1 Study of cDNA for TP53, Checkpoint Inhibition and Radiation in Children With Recurrent, Progressive or Refractory CNS Malignancies. [EARLY_Phase 1]

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Summary

An early-phase trial evaluating TP53 cDNA gene therapy combined with checkpoint inhibition and radiation in children with recurrent or refractory central nervou…

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Diseases / indications

• Atypical Teratoid Rhabdoid Tumor
• Embryonal Tumor of the Central Nervous System
• Ependymoma
• High-grade Glioma
• Medulloblastoma
• Pineoblastoma

Drugs mentioned

• Checkpoint inhibitor (unspecified)
• TP53 cDNA gene therapy (p53 cDNA)

Snippet

Sponsor: Children's National Research Institute | Conditions: CNS Malignancies, Medulloblastoma Recurrent | EARLY_Phase 1 | Status: NOT_YET_RECRUITING