High-grade Glioma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-08-29Clinical Trial Update: A Pilot Study Investigating Upfront Adaptive Immunotherapy Approach in Children, Adolescent and Young Adult (CAYA) Patients With Replication-Repair Deficient (RRD) High-Grade Gliomas (HGG) [NA]
A pilot clinical trial is investigating upfront adaptive immunotherapy for children, adolescents and young adults with replication-repair de…
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CLINICAL_TRIALS research · 2025-08-19Clinical Trial Update: Clinical Study on the Treatment of Malignant Brain Glioma by QH104 Cell Injection [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating QH104 cell injections for malignant brain gliomas, including glioblastoma multiforme and other high-gr…
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CLINICAL_TRIALS research · 2025-08-08Clinical Trial Update: Multi-Dimensional MRI Spatial Heterogeneity Analysis for Predicting Key Genes and Prognosis of High-Grade Gliomas: A Multi-Center Study
A multi-center clinical trial is recruiting to evaluate multi-dimensional MRI spatial heterogeneity for predicting key genes and prognosis i…
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CLINICAL_TRIALS research · 2025-07-29Clinical Trial Update: Effect H2 Water on QoL of Patients Receiving Radiotherapy for High Grade Gliomas. [Phase 2]
Phase 2 clinical trial evaluating whether hydrogen-rich water improves quality of life in patients receiving radiotherapy for high-grade mal…
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CLINICAL_TRIALS withdrawal · 2025-07-23Clinical Trial Update: Safety, Tolerability and Efficacy of JCXH-211 in Patients With Recurrent or Progressive High-Grade Glioma [Phase 1]
The Phase 1 trial of JCXH-211 in patients with recurrent or progressive high-grade glioma has been withdrawn.
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CLINICAL_TRIALS research · 2025-07-22Clinical Trial Update: Atovaquone Combined With Radiation in Children With Malignant Brain Tumors [Phase 1]
A Phase 1 clinical trial evaluating atovaquone in combination with radiation for pediatric malignant brain tumors is currently recruiting.
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CLINICAL_TRIALS withdrawal · 2025-07-22Clinical Trial Update: A Study of Bicalutamide With Brain Re-irradiation to Treat Recurrent/Progressive High Grade Glioma [Phase 1]
A Phase 1 clinical trial evaluating bicalutamide with brain re-irradiation for recurrent high-grade glioma/glioblastoma has been withdrawn.
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CLINICAL_TRIALS research · 2025-07-11Clinical Trial Update: Determine Maximum Tolerated Dose, Safety, and Tolerability of Rhenium (186Re) in Pediatric Recurrent, Refractory or Progressive Ependymoma and High-Grade Glioma [Phase 1]
Phase 1 clinical trial to determine the maximum tolerated dose, safety, and tolerability of a Rhenium-186 radiopharmaceutical in pediatric p…
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CLINICAL_TRIALS research · 2025-07-09Clinical Trial Update: BC008-1A Injection for Recurrent CNS WHO G4 Glioma [Phase 1]
A Phase 1 study of BC008-1A Injection for recurrent central nervous system WHO Grade 4 glioma (including glioblastoma) is currently recruiti…
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CLINICAL_TRIALS trial_result · 2025-07-08Clinical Trial Update: BIOhabitats: Biological Validation of Vascular Habitats Within Astrocytoma Grade 4 at Molecular, Cellular, and Histopathological Levels
This completed clinical trial evaluates BIOhabitats and biologically validates vascular habitats within Grade 4 astrocytoma (glioblastoma) a…
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CLINICAL_TRIALS trial_result · 2025-07-08Clinical Trial Update: HUMC 1612: Optune NovoTTF-200A System [Phase 1]
Phase 1 clinical trial update for HUMC 1612 evaluating the Optune NovoTTF-200A System in high-grade glioma and ependymoma; status shows comp…
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CLINICAL_TRIALS research · 2025-06-22Clinical Trial Update: STARLITE for Unresectable High-Grade Gliomas [Phase 1]
Phase 1 trial STARLITE for unresectable high-grade gliomas is currently recruiting at the University of Miami.
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CLINICAL_TRIALS trial_result · 2025-06-19Clinical Trial Update: Expedited Laser Interstitial Thermal Therapy + Chemoradiation For Newly Diagnosed High Grade Gliomas [EARLY_Phase 1]
This clinical trial update reports the completion of an early-phase study evaluating expedited laser interstitial thermal therapy in combina…
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CLINICAL_TRIALS trial_result · 2025-06-19Clinical Trial Update: Study to Evaluate 5-ALA Combined With CV01 Delivery of Ultrasound in Recurrent High Grade Glioma [Phase 1]
A Phase 1 trial evaluating the safety and feasibility of combining 5-ALA with CV01 ultrasound delivery for recurrent high-grade glioma has c…
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CLINICAL_TRIALS research · 2025-06-17Clinical Trial Update: A Phase 0/1 Study of cDNA for TP53, Checkpoint Inhibition and Radiation in Children With Recurrent, Progressive or Refractory CNS Malignancies. [EARLY_Phase 1]
An early-phase trial evaluating TP53 cDNA gene therapy combined with checkpoint inhibition and radiation in children with recurrent or refra…
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CLINICAL_TRIALS trial_result · 2025-06-17Clinical Trial Update: SonoClear Acoustic Coupling Fluid (ACF) Mimicking Brain Tissue [NA]
SonoClear is reporting completion of its clinical trial evaluating Acoustic Coupling Fluid (ACF) for brain-tissue–mimicking use in condition…
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CLINICAL_TRIALS trial_result · 2025-06-08Clinical Trial Update: Trial of Newly Diagnosed High Grade Glioma Treated With Concurrent Radiation Therapy, Temozolomide and BMX-001 [Phase 1, Phase 2]
This Phase 1/2 trial evaluating concurrent radiotherapy, temozolomide, and BMX-001 for newly diagnosed high-grade glioma has completed enrol…
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CLINICAL_TRIALS research · 2025-06-05Clinical Trial Update: 68Ga/177Lu-PSMA Theranostics in Recurrent Grade 3 and Grade 4 Glioma [NA]
This clinical trial update indicates recruitment is ongoing for a theranostic approach using 68Ga-PSMA and 177Lu-PSMA in recurrent high-grad…
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CLINICAL_TRIALS research · 2025-05-31Clinical Trial Update: A Ketogenic Diet as a Complementary Treatment on Patients With High-grade Gliomas and Brain Metastases [NA]
A clinical trial at Attikon Hospital is evaluating the ketogenic diet as a complementary treatment for patients with high-grade gliomas and …
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CLINICAL_TRIALS research · 2025-05-29Clinical Trial Update: MAPK Inhibition Combined With Anti-PD1 Therapy for BRAF-altered Pediatric Gliomas [Phase 1, Phase 2]
This clinical trial update describes a Phase 1/Phase 2 study exploring a MAPK pathway inhibitor in combination with anti-PD1 therapy for BRA…
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CLINICAL_TRIALS research · 2025-05-16Clinical Trial Update: Local, Targeted Therapy With Alpha Emitter [225Ac]Ac-DOTA-SP (TAT) in Glioma (WHO G3-G4) Progression [NA]
This entry notes that recruitment is ongoing for a local alpha-emitter therapy, [225Ac]Ac-DOTA-SP (TAT), being studied for glioblastoma and …
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CLINICAL_TRIALS research · 2025-05-13Clinical Trial Update: Phase 1 Study of Locoregional Injections of Ex Vivo Expanded Natural Killer Cells [Phase 1]
Phase 1 study to evaluate locoregional injections of ex vivo expanded natural killer cells in patients with high-grade glioma.
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CLINICAL_TRIALS research · 2025-04-11Clinical Trial Update: A Study of Chlorophyllin for the Management of Brain Radio-necrosis in Patients With Diffuse Glioma [Phase 2]
Phase 2 clinical trial evaluating chlorophyllin for the management of brain radionecrosis in patients with diffuse glioma is currently recru…
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CLINICAL_TRIALS research · 2025-04-09Clinical Trial Update: Injection of Active Allogeneic Natural Killer Cells in Patients With Gliomas [Phase 2]
A Phase 2 clinical trial evaluating injections of active allogeneic natural killer cells in patients with gliomas is currently recruiting.
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CLINICAL_TRIALS research · 2025-03-14Clinical Trial Update: Study of Sonodynamic Therapy in Participants with Recurrent High-Grade Glioma [EARLY_Phase 1]
An early-phase trial evaluating sonodynamic therapy for recurrent high-grade glioma is currently recruiting.