High-grade Glioma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-01-20Clinical Trial Update: Loc3CAR: Locoregional Delivery of B7-H3-CAR T Cells for Pediatric Patients With Primary CNS Tumors [Phase 1]
Clinical trial update indicating that Loc3CAR (B7-H3-CAR T cells) delivery is in early-phase pediatric CNS tumor trials and currently recrui…
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CLINICAL_TRIALS trial_result · 2026-01-14Clinical Trial Update: A Study of the Safety, Dosing, and Delivery of NEO100 in Patients With Pediatric Brain Tumors [Phase 1]
This Phase 1 clinical trial assesses the safety, dosing, and delivery of NEO100 in pediatric brain and CNS tumors and is not yet recruiting.
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CLINICAL_TRIALS research · 2026-01-09Clinical Trial Update: Gallium Maltolate for the Treatment of Pediatric Patients With Relapsed or Refractory Pediatric High-Grade Glioma and Atypical Teratoid Rhabdoid Tumor [Phase 1]
This clinical trial update describes a Phase 1 study of gallium maltolate for relapsed or refractory pediatric high-grade glioma and atypica…
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CLINICAL_TRIALS research · 2026-01-02Clinical Trial Update: Concurrent XRD-0394 With Radiation Therapy for High Grade Gliomas [EARLY_Phase 1]
A Phase 1 early trial evaluating XRD-0394 in combination with radiation therapy for high-grade glioma is currently recruiting.
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CLINICAL_TRIALS research · 2026-01-02Clinical Trial Update: Concurrent Azeliragon With Craniospinal Irradiation [Phase 1]
A Phase 1 clinical trial evaluating azeliragon in combination with craniospinal irradiation for patients with high-grade glioma and leptomen…
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CLINICAL_TRIALS research · 2025-12-29Clinical Trial Update: A Phase I Clinical Trial of a mRNA Vaccine for Recurrent or Progressive High-grade Glioma [Phase 1]
This update describes a Phase I clinical trial of an mRNA vaccine for recurrent or progressive high-grade glioma that is currently recruitin…
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CLINICAL_TRIALS trial_result · 2025-12-19Clinical Trial Update: Fluorescence Spectroscopy Guided Surgery [Phase 1]
Phase 1 clinical trial evaluating fluorescence spectroscopy guided surgery for patients with gliomas. The study including low-grade glioma a…
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CLINICAL_TRIALS research · 2025-12-18Clinical Trial Update: Peds CHAMP1ON - Hematopoietic Stem Cell And Monoclonal Antibody PD-1 Blockade for RecurreNt Pediatric High-Grade Glioma [Phase 1]
A Phase 1 clinical trial in pediatric patients with recurrent high-grade glioma evaluating hematopoietic stem cell therapy in combination wi…
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CLINICAL_TRIALS research · 2025-12-18Clinical Trial Update: Telehealth Visits to Discuss Advanced Directives for Patients Newly Diagnosed With High Grade Glioma [NA]
A recruiting clinical trial at the University of Rochester is exploring telehealth visits to discuss advanced directives for patients newly …
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CLINICAL_TRIALS research · 2025-12-16Clinical Trial Update: Fluorescence Enhanced Stereotactic Surgery (FESS)
A clinical trial update indicates that a study evaluating fluorescence-enhanced stereotactic surgery for high-grade glioma is currently recr…
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CLINICAL_TRIALS research · 2025-12-11Clinical Trial Update: Multiparametic Metabolic and Hypoxic PET/MRI for Disease Assessment in High Grade Glioma [EARLY_Phase 1]
An early-phase study evaluating multiparametric metabolic and hypoxic PET/MRI for disease assessment in high-grade glioma. The trial is curr…
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: 18F-Fluciclovine PET-MRI in High-grade Glioma [EARLY_Phase 1]
An early-phase trial evaluating 18F-Fluciclovine PET-MRI for imaging high-grade glioma is currently recruiting.
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: Phase I/IIa Study of Concomitant Radiotherapy With Olaparib and Temozolomide in Unresectable High Grade Gliomas Patients [Phase 1, Phase 2]
A Phase I/IIa clinical trial is evaluating the safety and feasibility of combining radiotherapy with olaparib and temozolomide in unresectab…
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CLINICAL_TRIALS research · 2025-12-03Clinical Trial Update: A Study of 68Ga-PSMA-11 PET Scans in People With Brain Tumors [EARLY_Phase 1]
Early-phase clinical trial studying Gallium-68 PSMA-11 PET imaging for patients with brain tumors, currently active but not recruiting.
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CLINICAL_TRIALS trial_result · 2025-11-24Clinical Trial Update: Nivolumab in Patients With IDH-Mutant Gliomas With and Without Hypermutator Phenotype [Phase 2]
A Phase 2 trial of nivolumab in IDH-mutant gliomas, with and without hypermutator phenotype, has results posted on ClinicalTrials.gov.
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CLINICAL_TRIALS research · 2025-11-20Clinical Trial Update: Study of LAM561 Acid in Pediatric Patients With Malignant Glioma and Other Advanced Solid Tumors [Phase 1, Phase 2]
A phase 1/2 clinical trial evaluating LAM561 Acid in pediatric patients with malignant glioma and other advanced solid tumors is currently r…
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CLINICAL_TRIALS research · 2025-11-20Clinical Trial Update: A Phase 0/1 Study of BDTX-1535 in Recurrent High-Grade Glioma (rHGG) and Newly Diagnosed Glioblastoma (nGBM) Participants With EGFR Alterations or Fusions [EARLY_Phase 1]
A Phase 0/1 study of BDTX-1535 in patients with recurrent high-grade glioma and newly diagnosed glioblastoma with EGFR alterations or fusion…
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CLINICAL_TRIALS research · 2025-11-04Clinical Trial Update: Intratumoral Extracellular Metabolic Impact of DFMO and AMXT 1501 in Patients With Diffuse or High Grade Glioma [EARLY_Phase 1]
Early-phase trial evaluating the intratumoral metabolic impact of DFMO combined with AMXT-1501 in patients with diffuse or high-grade glioma…
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CLINICAL_TRIALS trial_result · 2025-10-06Clinical Trial Update: Repeated Neural Stem Cell Based Virotherapy for Newly Diagnosed High Grade Glioma [Phase 1]
Phase 1 clinical trial evaluating repeated neural stem cell based virotherapy for newly diagnosed high-grade glioma.
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CLINICAL_TRIALS research · 2025-09-24Clinical Trial Update: Pilot Study of Mirtazapine for the Dual Tx of Depression and CINV in High-Grade Glioma Pts on TMZ [Phase 2]
Phase 2 pilot study evaluating mirtazapine for dual treatment of depression and chemotherapy-induced nausea and vomiting in patients with hi…
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CLINICAL_TRIALS trial_result · 2025-09-22Clinical Trial Update: hPG80 (Circulating Progastrin) as a Blood Biomarker for High-grade Glial Tumors
This update covers results from a completed clinical trial evaluating circulating progastrin (hPG80) as a blood biomarker for high-grade gli…
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CLINICAL_TRIALS research · 2025-09-17Clinical Trial Update: Focused Ultrasound Blood-Brain Barrier Disruption for the Treatment of High-Grade Glioma in Patients Undergoing Standard Chemotherapy [Phase 1]
A Phase 1 clinical trial is evaluating focused ultrasound to disrupt the blood-brain barrier in high-grade glioma patients undergoing standa…
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CLINICAL_TRIALS research · 2025-09-16Clinical Trial Update: Study of DSP-0390 in Patients With Recurrent High-Grade Glioma [EARLY_Phase 1]
DSP-0390 is being studied in an early-phase Phase 1 trial for recurrent high-grade glioma, including glioblastoma, and the study is currentl…
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CLINICAL_TRIALS trial_result · 2025-09-12Clinical Trial Update: Olaparib in Recurrent IDH-mutant Glioma [Phase 2]
Phase 2 trial of olaparib in recurrent IDH-mutant glioma has been completed.
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CLINICAL_TRIALS research · 2025-09-04Clinical Trial Update: C7R-GD2.CAR T Cells for Patients With GD2-expressing Brain Tumors (GAIL-B) [Phase 1]
Phase 1 clinical trial update for C7R-GD2.CAR T cells targeting GD2-expressing brain tumors, currently recruiting for DIPG, high-grade gliom…