High-grade Glioma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-03-13Clinical Trial Update: A Phase I Clinical Study of Intratumoral Injection GC001 in Patient With Recurrent or Progressive Gliomas [Phase 1]
Phase I study of intratumoral GC001 in patients with recurrent or progressive high-grade gliomas is currently recruiting.
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CLINICAL_TRIALS research · 2025-02-27Clinical Trial Update: Superselective Intra-arterial Cerebral Infusion of Temsirolimus in HGG [EARLY_Phase 1]
An early-phase (Phase 1) clinical trial is evaluating superselective intra-arterial cerebral infusion of temsirolimus for high-grade glioma,…
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CLINICAL_TRIALS trial_result · 2025-02-21Clinical Trial Update: Studying the Safety, Efficacy, and Pharmacokinetic Characteristics of BNCT in Patients With Recurrent High-grade Gliomas [Phase 1, Phase 2]
A terminated Phase 1/2 trial evaluated the safety, efficacy, and pharmacokinetics of boron neutron capture therapy (BNCT) for recurrent high…
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CLINICAL_TRIALS research · 2025-02-21Clinical Trial Update: Study of Olutasidenib and Temozolomide in HGG [Phase 2]
Phase 2 study evaluating olutasidenib in combination with temozolomide for high-grade gliomas is currently recruiting.
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CLINICAL_TRIALS research · 2025-02-18Clinical Trial Update: Clinical Study of Carbon Ion Radiotherapy for High-grade Glioma [NA]
The trial is currently recruiting to evaluate carbon ion radiotherapy for high-grade glioma (heavy ion radiotherapy).
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CLINICAL_TRIALS research · 2025-02-05Clinical Trial Update: GD2-CAR T Cells for Pediatric Brain Tumours [Phase 1]
Phase 1 trial evaluating GD2-CAR T cells for pediatric brain tumors is currently recruiting. The study targets medulloblastoma, embryonal tu…
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CLINICAL_TRIALS withdrawal · 2025-01-15Clinical Trial Update: Seizures During Radiotherapy for High-grade Gliomas [NA]
A clinical trial studying seizures during radiotherapy for high-grade gliomas has been terminated.
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CLINICAL_TRIALS research · 2024-12-24Clinical Trial Update: Bevacizumab Neoadjuvant Therapy for New High-grade Gliomas in the Brain [NA]
Bevacizumab is being studied as neoadjuvant therapy for new high-grade gliomas in the brain; the trial is currently recruiting.
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CLINICAL_TRIALS research · 2024-12-18Clinical Trial Update: Feasibility of Aspirate Tissue Monitoring in Neuro-oncological Surgery [NA]
The update notes a feasibility study evaluating aspirate tissue monitoring during neuro-oncological surgery for high-grade gliomas. The tria…
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CLINICAL_TRIALS research · 2024-12-16Clinical Trial Update: Surgical Suction Aspirates Fluorescence Measurement
A recruiting clinical trial at Kuopio University Hospital is evaluating fluorescence measurement of surgical suction aspirates in patients w…
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CLINICAL_TRIALS trial_result · 2024-12-06Clinical Trial Update: A Pilot Study of Glioma Associated Antigen Vaccines in Conjunction with Poly-ICLC in Pediatric Gliomas [Phase 1]
This Phase 1 pilot trial evaluated glioma-associated antigen vaccines with the Toll-like receptor 3 agonist Poly-ICLC in pediatric gliomas a…
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CLINICAL_TRIALS withdrawal · 2024-12-04Clinical Trial Update: Study to Assess Xevinapant in Preoperative Subjects With Recurrent High-Grade Glioma (rHGG) [Phase 1]
A Phase 1 trial evaluating Xevinapant in preoperative patients with recurrent high-grade glioma has been withdrawn.
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CLINICAL_TRIALS research · 2024-12-03Clinical Trial Update: FET PET in Differentiating Tumour Progression From Pseudoprogression in High Grade Glioma [Phase 2]
A Phase 2 clinical trial at Singapore General Hospital is evaluating FET PET imaging to differentiate tumor progression from pseudoprogressi…
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CLINICAL_TRIALS trial_result · 2024-12-02Clinical Trial Update: Nivolumab in Combination With Temozolomide and Radiotherapy in Children and Adolescents With Newly Diagnosed High-grade Glioma [Phase 1, Phase 2]
An update on a Phase 1/2 trial evaluating nivolumab in combination with temozolomide and radiotherapy for newly diagnosed pediatric high-gra…
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CLINICAL_TRIALS research · 2024-11-29Clinical Trial Update: Study of Safety and Pharmacokinetic Properties of Oral OKN-007 in Patients with Recurrent High-Grade Glioma [Phase 1]
Phase 1 study assessing safety and pharmacokinetics of oral OKN-007 in adults with recurrent high-grade glioma. The trial includes patients …
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CLINICAL_TRIALS research · 2024-11-29Clinical Trial Update: Recurrent High Grade Glioma Treated by LITT [NA]
A new clinical trial entry for recurrent high-grade glioma using laser interstitial thermal therapy (LITT) is currently recruiting at Beijin…
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CLINICAL_TRIALS trial_result · 2024-10-09Clinical Trial Update: REGN2810 in Pediatric Patients With Relapsed, Refractory Solid, or Central Nervous System (CNS) Tumors and Safety and Efficacy of REGN2810 in Combination With Radiotherapy in Pediatric Patients With Newly Diagnosed or Recurrent Glioma [Phase 1, Phase 2]
Regeneron’s cemiplimab (REGN2810) was studied in pediatric patients with relapsed/refractory solid tumors and CNS tumors, including a safety…
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: Autologous Dendritic Cells, Metronomic Cyclophosphamide and Checkpoint Blockade in Children With Relapsed HGG [Phase 1, Phase 2]
Completed Phase 1/Phase 2 trial in children with relapsed high-grade glioma evaluating autologous dendritic cells with metronomic cyclophosp…
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: Omental Tissue Autograft in Human Recurrent Glioblastoma Multiforme (rGBM) [NA]
This clinical trial update indicates recruitment for a study evaluating omental tissue autograft in patients with recurrent glioblastoma mul…
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CLINICAL_TRIALS research · 2024-08-06Clinical Trial Update: IDH1 and OCT4 in High Grade Astrocytoma
This clinical trial update indicates a study evaluating IDH1 and OCT4 in high-grade astrocytoma is currently recruiting.
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CLINICAL_TRIALS trial_result · 2024-08-05Clinical Trial Update: Effect of Perampanel on Peritumoral Hyperexcitability in HGG [Phase 1, Phase 2]
Phase 1/2 study evaluating perampanel for reducing peritumoral hyperexcitability in patients with high-grade glioma; the trial completed and…
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CLINICAL_TRIALS research · 2024-07-03Clinical Trial Update: Experiences and Needs of Patients With a High-grade Glioma and Their Caregivers
This clinical trial investigates the experiences and support needs of patients with high-grade glioma and their caregivers; the study is cur…
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CLINICAL_TRIALS trial_result · 2024-06-26Clinical Trial Update: Phase 1/2a Study of Oral BAL101553 in Adult Patients With Solid Tumors or Glioblastoma or High-grade Glioma [Phase 1, Phase 2]
This ClinicalTrials.gov update reports that results for the Phase 1/2a trial of oral BAL101553 in adults with solid tumors, glioblastoma, an…
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CLINICAL_TRIALS withdrawal · 2024-06-06Clinical Trial Update: A Multicenter, Study of the Safety and Pharmacokinetics of Intravenously Infused Berubicin in Pediatric Patients With Progressive, Refractory, or Recurrent High Grade Gliomas [Phase 1]
Phase 1 multicenter trial assessing the safety and pharmacokinetics of intravenously infused berubicin in pediatric patients with progressiv…
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CLINICAL_TRIALS research · 2024-05-08Clinical Trial Update: Adjuvant Dendritic Cell Immunotherapy for Pediatric Patients With High-grade Glioma or Diffuse Intrinsic Pontine Glioma [Phase 1, Phase 2]
Phase 1/2 trial evaluating adjuvant dendritic cell immunotherapy in pediatric high-grade glioma and diffuse intrinsic pontine glioma; the st…