High-grade Glioma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: A Study of RNA-lipid Particle (RNA-LP) Vaccines for Newly Diagnosed Pediatric High-Grade Gliomas (pHGG) and Adult Glioblastoma (GBM) [Phase 1]
A Phase 1 clinical trial evaluating RNA-lipid particle vaccines for newly diagnosed pediatric high-grade gliomas and adult glioblastoma is c…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Dual-Targeting CAR-NK Cells for Recurrent/Progressive Glioblastoma and High-Grade Glioma [Phase 1]
A Phase 1 clinical trial evaluating dual-targeting CAR-NK cells for recurrent/progressive glioblastoma and high-grade gliomas is currently r…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant [Phase 2]
Phase 2 clinical trial exploring ribociclib with everolimus or with temozolomide for high-grade gliomas and related diffuse gliomas; recruit…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG) [Phase 1, Phase 2]
This clinical trial assesses selinexor with radiation therapy for newly diagnosed diffuse intrinsic pontine glioma and high-grade glioma, in…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: Entrectinib as a Single Agent in Upfront Therapy for Children <3 Years of Age With NTRK1/2/3 or ROS1-FUSED CNS Tumors [Phase 2]
A Phase 2 trial evaluating Entrectinib as a single-agent upfront therapy for children under 3 with NTRK1/2/3 or ROS1-fused CNS tumors is cur…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: Preoperative Radiosurgery for the Treatment of High Grade Glioma, NeoGlioma Trial [Phase 1]
Phase 1 NeoGlioma trial evaluating preoperative radiosurgery for high-grade glioma is currently recruiting.
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: A Study Comparing Abemaciclib Plus Temozolomide to Temozolomide Monotherapy in Children and Young Adults With High-grade Glioma Following Radiotherapy [Phase 2]
A Phase 2 clinical trial evaluating abemaciclib in combination with temozolomide versus temozolomide alone for pediatric and young adult hig…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: A Study of Temodar With Abexinostat (PCI-24781) for Patients With Recurrent Glioma [Phase 1]
This clinical trial investigates temozolomide (Temodar) in combination with the HDAC inhibitor Abexinostat for recurrent high-grade gliomas,…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: A Study to Test a New Fluid to Improve the Quality of Images Obtained by Using Sound Waves (Ultrasound) During Surgery [NA]
A clinical trial is testing a new fluid to improve ultrasound image quality during brain tumor surgery and is currently recruiting. Sponsor:…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Open-Label Study to Evaluate the Safety, Tolerability and Efficacy of the Oncolytic HSV1 MVR-C5252 [Phase 1]
Open-label Phase 1 study at Duke University evaluating the safety, tolerability, and efficacy of the oncolytic herpes simplex virus-1 therap…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating Lutathera (lutetium-177 dotatate) for recurrent or progressive high-grade central nervous system tumor…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Dabrafenib Combined With Trametinib After Radiation Therapy in Treating Patients With Newly-Diagnosed High-Grade Glioma [Phase 2]
A Phase 2 clinical trial update examining the combination of dabrafenib and trametinib after radiation therapy for newly diagnosed high-grad…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Evaluate the Safety and Preliminary Efficacy of the Combination of NaviFUS System With Re-irradiation for rGBM Patients [NA]
Clinical trial update on combining the NaviFUS System with re-irradiation for recurrent glioblastoma and high-grade glioma (WHO III–IV); the…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021) [Phase 1]
A Phase 1 PNOC021 trial of trametinib and everolimus for pediatric and young adult patients with recurrent gliomas has been suspended.
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Efficacy of Mirdametinib Alone or Combination With Radiotherapy for Germline and Sporadic NF1-Altered High-Grade Glioma [Phase 2]
Phase 2 trial evaluating Mirdametinib alone or with radiotherapy for germline and sporadic NF1-altered high-grade glioma; status is not yet …
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: Study of Tovorafenib in High-Grade Glioma and Diffuse Intrinsic Pontine Glioma (DIPG) [Phase 2]
Phase 2 study of tovorafenib for high-grade glioma with BRAF aberration and diffuse intrinsic pontine glioma; the trial is not yet recruitin…
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma [Phase 2]
Phase 2 clinical trial of the PEP-CMV CMV antigen-targeted vaccine for newly diagnosed pediatric high-grade glioma, diffuse intrinsic pontin…
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CLINICAL_TRIALS research · 2026-04-06Clinical Trial Update: Local, Targeted Therapy With Alpha Emitter [225Ac]Ac-DOTA-SP (TAT) In Newly Diagnosed Glioma (WHO G3-G4) [NA]
A clinical trial is evaluating local targeted alpha emitter therapy using 225Ac-DOTA-SP (TAT) for newly diagnosed glioma (WHO grade 3-4) and…
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations [Phase 2]
Phase 2 clinical trial update announcing the evaluation of FORE8394 in participants with cancers harboring BRAF alterations, including high-…
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CLINICAL_TRIALS research · 2026-03-31Clinical Trial Update: Targeted Pediatric High-Grade Glioma Therapy
A pediatric clinical trial is currently recruiting to evaluate a targeted therapy for high-grade gliomas, including diffuse intrinsic pontin…
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: A Phase 1b Study of PTC596 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma and High Grade Glioma [Phase 1]
Phase 1b study of the investigational drug PTC596 in children with newly diagnosed diffuse intrinsic pontine glioma and high-grade glioma; t…
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CLINICAL_TRIALS research · 2026-03-23Clinical Trial Update: Evaluating the Safety and Efficacy of BioTTT001 in Patients With Recurrent/Progressive High-grade Glioma. [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating BioTTT001 for recurrent high-grade glioma, currently enrolling by invitation to assess safety and prel…
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CLINICAL_TRIALS research · 2026-03-23Clinical Trial Update: MRI in High-Grade Glioma Patients Undergoing Chemoradiation [NA]
This clinical trial update notes that an MRI study in high-grade glioma patients undergoing chemoradiation is currently recruiting.
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CLINICAL_TRIALS research · 2026-03-18Clinical Trial Update: Novel Targeted Radiotherapy in Pediatric Patients With Inoperable Relapsed or Refractory HGG [Phase 1]
This is a Phase 1 clinical trial update for a novel targeted radiotherapy in pediatric patients with inoperable relapsed or refractory high-…
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CLINICAL_TRIALS research · 2026-03-18Clinical Trial Update: Dual-Targeting CAR-NK Cells for Recurrent/Progressive Glioblastoma and High-Grade Glioma [Phase 1]
Phase 1 clinical trial evaluating dual-targeting CAR-NK cells for recurrent or progressive glioblastoma and high-grade glioma is currently r…