High-grade Glioma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-04-23Clinical Trial Update: Adoptive Cellular Therapy in Pediatric Patients With High-grade Gliomas [Phase 1]
Phase 1 trial evaluating adoptive cellular therapy in pediatric patients with high-grade gliomas; the study has been terminated and results …
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CLINICAL_TRIALS trial_result · 2026-04-15Clinical Trial Update: APT-weighted and Diffusion MRI for Characterizing Tumor Infiltration in High-Grade Gliomas
This clinical trial update describes a study using APT-weighted and diffusion MRI to characterize tumor infiltration in high-grade gliomas. …
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CLINICAL_TRIALS trial_result · 2026-03-30Clinical Trial Update: Use of Fluorescence in Gliomas
A clinical trial evaluating fluorescence-guided techniques in glioma surgery has completed, including participants with glioblastoma and oth…
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CLINICAL_TRIALS trial_result · 2026-03-18Clinical Trial Update: A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion [EARLY_Phase 1]
A pilot Phase 1 trial evaluating larotrectinib for newly diagnosed high-grade glioma with NTRK gene fusions, including diffuse intrinsic pon…
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CLINICAL_TRIALS trial_result · 2026-01-14Clinical Trial Update: A Study of the Safety, Dosing, and Delivery of NEO100 in Patients With Pediatric Brain Tumors [Phase 1]
This Phase 1 clinical trial assesses the safety, dosing, and delivery of NEO100 in pediatric brain and CNS tumors and is not yet recruiting.
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CLINICAL_TRIALS trial_result · 2025-12-19Clinical Trial Update: Fluorescence Spectroscopy Guided Surgery [Phase 1]
Phase 1 clinical trial evaluating fluorescence spectroscopy guided surgery for patients with gliomas. The study including low-grade glioma a…
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CLINICAL_TRIALS trial_result · 2025-11-24Clinical Trial Update: Nivolumab in Patients With IDH-Mutant Gliomas With and Without Hypermutator Phenotype [Phase 2]
A Phase 2 trial of nivolumab in IDH-mutant gliomas, with and without hypermutator phenotype, has results posted on ClinicalTrials.gov.
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CLINICAL_TRIALS trial_result · 2025-10-06Clinical Trial Update: Repeated Neural Stem Cell Based Virotherapy for Newly Diagnosed High Grade Glioma [Phase 1]
Phase 1 clinical trial evaluating repeated neural stem cell based virotherapy for newly diagnosed high-grade glioma.
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CLINICAL_TRIALS trial_result · 2025-09-22Clinical Trial Update: hPG80 (Circulating Progastrin) as a Blood Biomarker for High-grade Glial Tumors
This update covers results from a completed clinical trial evaluating circulating progastrin (hPG80) as a blood biomarker for high-grade gli…
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CLINICAL_TRIALS trial_result · 2025-09-12Clinical Trial Update: Olaparib in Recurrent IDH-mutant Glioma [Phase 2]
Phase 2 trial of olaparib in recurrent IDH-mutant glioma has been completed.
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CLINICAL_TRIALS trial_result · 2025-07-08Clinical Trial Update: BIOhabitats: Biological Validation of Vascular Habitats Within Astrocytoma Grade 4 at Molecular, Cellular, and Histopathological Levels
This completed clinical trial evaluates BIOhabitats and biologically validates vascular habitats within Grade 4 astrocytoma (glioblastoma) a…
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CLINICAL_TRIALS trial_result · 2025-07-08Clinical Trial Update: HUMC 1612: Optune NovoTTF-200A System [Phase 1]
Phase 1 clinical trial update for HUMC 1612 evaluating the Optune NovoTTF-200A System in high-grade glioma and ependymoma; status shows comp…
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CLINICAL_TRIALS trial_result · 2025-06-19Clinical Trial Update: Expedited Laser Interstitial Thermal Therapy + Chemoradiation For Newly Diagnosed High Grade Gliomas [EARLY_Phase 1]
This clinical trial update reports the completion of an early-phase study evaluating expedited laser interstitial thermal therapy in combina…
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CLINICAL_TRIALS trial_result · 2025-06-19Clinical Trial Update: Study to Evaluate 5-ALA Combined With CV01 Delivery of Ultrasound in Recurrent High Grade Glioma [Phase 1]
A Phase 1 trial evaluating the safety and feasibility of combining 5-ALA with CV01 ultrasound delivery for recurrent high-grade glioma has c…
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CLINICAL_TRIALS trial_result · 2025-06-17Clinical Trial Update: SonoClear Acoustic Coupling Fluid (ACF) Mimicking Brain Tissue [NA]
SonoClear is reporting completion of its clinical trial evaluating Acoustic Coupling Fluid (ACF) for brain-tissue–mimicking use in condition…
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CLINICAL_TRIALS trial_result · 2025-06-08Clinical Trial Update: Trial of Newly Diagnosed High Grade Glioma Treated With Concurrent Radiation Therapy, Temozolomide and BMX-001 [Phase 1, Phase 2]
This Phase 1/2 trial evaluating concurrent radiotherapy, temozolomide, and BMX-001 for newly diagnosed high-grade glioma has completed enrol…
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CLINICAL_TRIALS trial_result · 2025-02-21Clinical Trial Update: Studying the Safety, Efficacy, and Pharmacokinetic Characteristics of BNCT in Patients With Recurrent High-grade Gliomas [Phase 1, Phase 2]
A terminated Phase 1/2 trial evaluated the safety, efficacy, and pharmacokinetics of boron neutron capture therapy (BNCT) for recurrent high…
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CLINICAL_TRIALS trial_result · 2024-12-06Clinical Trial Update: A Pilot Study of Glioma Associated Antigen Vaccines in Conjunction with Poly-ICLC in Pediatric Gliomas [Phase 1]
This Phase 1 pilot trial evaluated glioma-associated antigen vaccines with the Toll-like receptor 3 agonist Poly-ICLC in pediatric gliomas a…
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CLINICAL_TRIALS trial_result · 2024-12-02Clinical Trial Update: Nivolumab in Combination With Temozolomide and Radiotherapy in Children and Adolescents With Newly Diagnosed High-grade Glioma [Phase 1, Phase 2]
An update on a Phase 1/2 trial evaluating nivolumab in combination with temozolomide and radiotherapy for newly diagnosed pediatric high-gra…
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CLINICAL_TRIALS trial_result · 2024-10-09Clinical Trial Update: REGN2810 in Pediatric Patients With Relapsed, Refractory Solid, or Central Nervous System (CNS) Tumors and Safety and Efficacy of REGN2810 in Combination With Radiotherapy in Pediatric Patients With Newly Diagnosed or Recurrent Glioma [Phase 1, Phase 2]
Regeneron’s cemiplimab (REGN2810) was studied in pediatric patients with relapsed/refractory solid tumors and CNS tumors, including a safety…
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: Autologous Dendritic Cells, Metronomic Cyclophosphamide and Checkpoint Blockade in Children With Relapsed HGG [Phase 1, Phase 2]
Completed Phase 1/Phase 2 trial in children with relapsed high-grade glioma evaluating autologous dendritic cells with metronomic cyclophosp…
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: Omental Tissue Autograft in Human Recurrent Glioblastoma Multiforme (rGBM) [NA]
This clinical trial update indicates recruitment for a study evaluating omental tissue autograft in patients with recurrent glioblastoma mul…
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CLINICAL_TRIALS trial_result · 2024-08-05Clinical Trial Update: Effect of Perampanel on Peritumoral Hyperexcitability in HGG [Phase 1, Phase 2]
Phase 1/2 study evaluating perampanel for reducing peritumoral hyperexcitability in patients with high-grade glioma; the trial completed and…
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CLINICAL_TRIALS trial_result · 2024-06-26Clinical Trial Update: Phase 1/2a Study of Oral BAL101553 in Adult Patients With Solid Tumors or Glioblastoma or High-grade Glioma [Phase 1, Phase 2]
This ClinicalTrials.gov update reports that results for the Phase 1/2a trial of oral BAL101553 in adults with solid tumors, glioblastoma, an…
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CLINICAL_TRIALS trial_result · 2024-04-03Clinical Trial Update: Phase 2a Study of CAN-2409 With Standard Radiation Therapy for Malignant Glioma [Phase 2]
Phase 2a study of CAN-2409 with standard radiation therapy in malignant glioma (including glioblastoma multiforme) has completed; results po…