Brain Metastases
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2025-08-19Clinical Trial Update: E6201 and Dabrafenib for the Treatment of Central Nervous System Metastases From BRAF V600 Mutated Metastatic Melanoma [Phase 1]
Phase 1 study evaluating E6201 in combination with dabrafenib for central nervous system metastases from BRAF V600-mutated metastatic melano…
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CLINICAL_TRIALS trial_result · 2025-08-17Clinical Trial Update: Pemetrexed/Platinum With or Without Bevacizumab in Brain Metastases From Patients With EGFR/ALK Negative Non-Squamous Non-small Cell Lung Cancer [Phase 3]
A Phase 3 trial evaluating pemetrexed/platinum with or without bevacizumab in patients with EGFR/ALK-negative non-squamous non-small cell lu…
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CLINICAL_TRIALS research · 2025-08-17Clinical Trial Update: Corticodependent or Corticoresistant Brain Radionecrosis After Radiotherapy for Brain Metastases [Phase 3]
A Phase 3 clinical trial evaluating corticodependent or corticoresistant brain radionecrosis after radiotherapy for brain metastases, curren…
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CLINICAL_TRIALS research · 2025-08-15Clinical Trial Update: MRI Following Stereotactic Radiosurgery (SRS) for Brain Metastases [NA]
Clinical trial update on MRI after stereotactic radiosurgery for brain metastases; the study is currently active but not recruiting.
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CLINICAL_TRIALS withdrawal · 2025-08-13Clinical Trial Update: Study of Lenvatinib Plus Pembrolizumab in IO Refractory mRCC Patients With Brain Metastases [Phase 2]
This Phase 2 trial of lenvatinib plus pembrolizumab in immune-refractory metastatic renal cell carcinoma with brain metastases has been with…
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CLINICAL_TRIALS research · 2025-08-12Clinical Trial Update: Exploration of the Safety and Efficacy of T-DXd Concurrent With Brain Radiotherapy in Patients With Brain Metastases HER2-positive/HER2-low Advanced Breast Cancer [NA]
A clinical trial is exploring the safety and efficacy of trastuzumab deruxtecan (T-DXd) given concurrently with brain radiotherapy in patien…
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CLINICAL_TRIALS trial_result · 2025-08-12Clinical Trial Update: 7T MRI Scan for the Early Detection of Melanoma Brain Metastases [NA]
A terminated clinical trial evaluating 7T MRI for the early detection of brain metastases in patients with stage IV cutaneous melanoma.
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CLINICAL_TRIALS research · 2025-08-12Clinical Trial Update: Comparison of Molecular-Genetic Concordance of the Primary Tumor and Brain Metastases of Colorectal Cancer
This clinical trial is evaluating the molecular-genetic concordance between primary colorectal tumors and brain metastases and is currently …
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CLINICAL_TRIALS research · 2025-08-11Clinical Trial Update: Trastuzumab Rezetecan Combined With Radiotherapy Versus Trastuzumab Rezetecan in the Treatment of HER2-positive Advanced Breast Cancer With Brain Metastases [Phase 2]
This Phase 2 clinical trial is comparing trastuzumab rezetecan with radiotherapy versus trastuzumab rezetecan alone in patients with HER2-po…
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CLINICAL_TRIALS trial_result · 2025-08-08Clinical Trial Update: Evaluation of Cabozantinib in Metastatic Renal Cell Carcinoma (mRCC) With Brain Metastases [Phase 2]
Phase 2 trial evaluating cabozantinib in metastatic renal cell carcinoma with brain metastases has completed.
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CLINICAL_TRIALS research · 2025-08-08Clinical Trial Update: ASL in Brain Metastasis MRI Following Gamma Knife Treatment [NA]
A clinical trial is evaluating arterial spin labeling (ASL) MRI for monitoring brain metastases after Gamma Knife treatment; the study is cu…
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CLINICAL_TRIALS trial_result · 2025-08-07Clinical Trial Update: Pembrolizumab Plus Bevacizumab for Treatment of Brain Metastases in Metastatic Melanoma or Non-small Cell Lung Cancer (NSCLC) [Phase 2]
Phase 2 trial evaluating pembrolizumab in combination with bevacizumab for treatment of brain metastases in metastatic melanoma or non-small…
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CLINICAL_TRIALS research · 2025-08-06Clinical Trial Update: Multimodal Large Model-Driven Risk and Prognosis Assessment for Brain Metastases in Lung Cancer
This document reports a clinical trial investigating AI-driven risk and prognosis assessment for brain metastases in non-small cell lung can…
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CLINICAL_TRIALS trial_result · 2025-08-05Clinical Trial Update: Precise DCE-MRI in Diagnosing Participants With Recurrent High Grade Glioma or Melanoma Brain Metastases [NA]
This update notes a terminated clinical trial at the University of Southern California evaluating precise dynamic contrast-enhanced MRI (DCE…
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CLINICAL_TRIALS research · 2025-08-03Clinical Trial Update: Automated Detection of Brain Metastases on MRI
Clinical trial update for Robovision BV's automated MRI detection system for brain metastases, currently enrolling by invitation.
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CLINICAL_TRIALS trial_result · 2025-07-24Clinical Trial Update: Lorlatinib in ROS1+ NSCLC With Brain Metastasis [Phase 2]
Lorlatinib is being studied in a Phase 2 trial for ROS1-positive non-small cell lung cancer with brain metastases, which is currently not ye…
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CLINICAL_TRIALS trial_result · 2025-07-23Clinical Trial Update: X-396(Ensartinib) Capsules in ALK-Positive NSCLC Patients With Brain Metastases [Phase 2]
Phase 2 study update of X-396 (ensartinib) in ALK-positive non-small cell lung cancer patients with brain metastases. The trial status is ac…
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CLINICAL_TRIALS trial_result · 2025-07-20Clinical Trial Update: Stereotactic Radiosurgery in Treating Patients With Large Brain Metastases [Phase 1]
A Phase 1 clinical trial evaluating stereotactic radiosurgery for patients with large brain metastases; the study is currently active but no…
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CLINICAL_TRIALS trial_result · 2025-07-18Clinical Trial Update: Pre- Versus Post-operative SRS for Resectable Brain Metastases [Phase 3]
A Phase 3 trial comparing pre-operative versus post-operative stereotactic radiosurgery for resectable brain metastases has been terminated.
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CLINICAL_TRIALS research · 2025-07-16Clinical Trial Update: SRS/SRT/Hypo-RT Versus HA-WBRT for No More Than 10 Brain Metastases in SCLC [Phase 3]
Phase 3 clinical trial comparing SRS/SRT/Hypo-RT to hippocampal-avoidance whole-brain radiotherapy for patients with up to 10 brain metastas…
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CLINICAL_TRIALS research · 2025-07-03Clinical Trial Update: Neurocognitive Functioning With Genu-Sparing Whole Brain Radiation Therapy for Brain Metastases [NA]
This clinical trial is evaluating neurocognitive functioning with genu-sparing whole brain radiation therapy for brain metastases and is cur…
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CLINICAL_TRIALS research · 2025-07-02Clinical Trial Update: Neoadjuvant Radiosurgery for Resectable Brain Metastases: Phase I/II Study [Phase 1, Phase 2]
A Phase I/II clinical trial evaluating neoadjuvant radiosurgery for patients with resectable brain metastases, currently recruiting.
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CLINICAL_TRIALS research · 2025-06-29Clinical Trial Update: Risk and Prognosis of Brain Metastasis in Non-Small Cell Lung Cancer
A registered clinical trial sponsored by Fudan University investigates the risk and prognosis of brain metastases in patients with non-small…
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CLINICAL_TRIALS trial_result · 2025-06-27Clinical Trial Update: Accelerated Checkpoint Therapy for Any Steroid Dependent Patient With Brain Metastases [Phase 2]
This document provides a Phase 2 clinical trial update that accelerated checkpoint therapy for adult patients with brain metastases has been…
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CLINICAL_TRIALS trial_result · 2025-06-26Clinical Trial Update: Pre-operative Stereotactic Radiosurgery Followed by Resection for Brain Metastases [NA]
This trial update reports completion and posted results for a study evaluating pre-operative stereotactic radiosurgery followed by surgical …