Brain Metastases
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CLINICAL_TRIALS withdrawal · 2026-03-31Clinical Trial Update: Phase Ib/II Trial of Abemaciclib and Elacestrant in Patients With Brain Metastasis Due to HR+/Her2- Breast Cancer [Phase 1, Phase 2]
A Phase Ib/II study of Abemaciclib plus Elacestrant for brain metastases stemming from HR+/HER2- breast cancer was terminated.
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CLINICAL_TRIALS withdrawal · 2025-08-13Clinical Trial Update: Study of Lenvatinib Plus Pembrolizumab in IO Refractory mRCC Patients With Brain Metastases [Phase 2]
This Phase 2 trial of lenvatinib plus pembrolizumab in immune-refractory metastatic renal cell carcinoma with brain metastases has been with…
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CLINICAL_TRIALS withdrawal · 2025-06-15Clinical Trial Update: A Window of Opportunity Study of Patritumab Deruxtecan in Patients With Brain Metastases [Phase 2]
A Phase 2 study evaluating patritumab deruxtecan for brain metastases has been withdrawn from ClinicalTrials.gov.
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CLINICAL_TRIALS withdrawal · 2025-05-26Clinical Trial Update: Cemiplimab for the Treatment of Untreated Brain Metastases From PD-L1 >= 50% Non-Small Cell Lung Cancer [Phase 2]
A Phase 2 trial evaluating cemiplimab for untreated brain metastases in patients with PD-L1 >= 50% non-small cell lung cancer has been withd…
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CLINICAL_TRIALS withdrawal · 2024-12-20Clinical Trial Update: Durvalumab (MEDI4736) and Radiosurgery (fSRT Vs. PULSAR) for the Treatment of Non-Small Cell Lung Cancer Brain Metastases [Phase 2]
A Phase 2 trial evaluating durvalumab with radiosurgery for brain metastases from non-small cell lung cancer has been withdrawn.
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CLINICAL_TRIALS withdrawal · 2024-05-29Clinical Trial Update: JDQ443 for KRAS G12C NSCLC Brain Metastases [Phase 2]
A Phase 2 trial of JDQ-443 for KRAS G12C-mutant non-small cell lung cancer with brain metastases has been withdrawn.
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CLINICAL_TRIALS withdrawal · 2018-07-05Clinical Trial Update: Evaluation of Lucanthone to Whole Brain Radiation Therapy in Patients With Brain Metastases From Non-Small Cell Lung Cancer [Phase 2]
A Phase 2 trial evaluating lucanthone in combination with whole-brain radiation therapy for brain metastases from non-small cell lung cancer…
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CLINICAL_TRIALS withdrawal · 2017-05-04Clinical Trial Update: 64-Cu Labeled Brain PET/MRI for MM-302 in Advanced HER2+ Cancers With Brain Mets [EARLY_Phase 1]
An early-phase trial of MM-302 in advanced HER2-positive cancers with brain metastases has been withdrawn.
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CLINICAL_TRIALS withdrawal · 2017-04-21Clinical Trial Update: BBBD Followed By Methotrexate and Carboplatin With or Without Trastuzumab in Treating Women With Breast Cancer That Has Spread to the Brain [Phase 1, Phase 2]
This trial evaluating BBBD followed by methotrexate and carboplatin with or without trastuzumab for breast cancer with brain metastases has …
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CLINICAL_TRIALS withdrawal · 2017-03-14Clinical Trial Update: Neurocognitive Outcomes In Patients Treated With Radiotherapy For Five Or More Brain Metastases [NA]
The clinical trial evaluating neurocognitive outcomes after radiotherapy for patients with five or more brain metastases has been withdrawn.
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CLINICAL_TRIALS withdrawal · 2016-04-21Clinical Trial Update: Combo of Abraxane, TMZ, Bevacizumab in Metastatic Melanoma With Brain Metastases [Phase 1, Phase 2]
The University of Arizona-sponsored Phase 1/2 trial of Abraxane plus temozolomide and bevacizumab for metastatic melanoma with brain metasta…
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CLINICAL_TRIALS withdrawal · 2015-04-10Clinical Trial Update: Safety Study of 2DG With Stereotactic Radiosurgery [Phase 1]
A Phase 1 safety study of 2-Deoxy-D-glucose with stereotactic radiosurgery for intracranial neoplasms and brain metastases has been withdraw…
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CLINICAL_TRIALS withdrawal · 2014-07-24Clinical Trial Update: Evaluation of Cabazitaxel in Patients With Brain Metastasis Secondary to Breast Cancer and NSCLC [Phase 2]
A Phase 2 trial evaluating cabazitaxel for brain metastases arising from breast cancer and non-small cell lung cancer has been withdrawn.
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CLINICAL_TRIALS withdrawal · 2014-03-07Clinical Trial Update: Phase I Dose Escalation in Patients With 1-3 Unresectable Brain Metastases [Phase 1]
A Phase I dose-escalation trial in patients with 1-3 unresectable brain metastases was withdrawn, according to ClinicalTrials.gov.
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CLINICAL_TRIALS withdrawal · 2014-02-04Clinical Trial Update: Surgery and Whole Brain Radiotherapy (RT) Versus Whole Brain Radiotherapy (RT) and Radiosurgery for 1-3 Resectable Brain Metastases [Phase 3]
A Phase 3 trial comparing surgery plus whole-brain radiotherapy versus whole-brain radiotherapy with radiosurgery for 1-3 resectable brain m…
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CLINICAL_TRIALS withdrawal · 2013-06-13Clinical Trial Update: Surgery Versus Radiosurgery for the Treatment of Single Brain Metastases [NA]
The clinical trial NCT01295970 comparing surgery versus radiosurgery for a single brain metastasis has been withdrawn.
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CLINICAL_TRIALS withdrawal · 2012-10-04Clinical Trial Update: Stereotactic Radiosurgery and Erlotinib in Treating Patients With Non-Small Cell Lung Cancer and Brain Metastases [Phase 1]
A Phase 1 trial evaluating stereotactic radiosurgery with erlotinib for non-small cell lung cancer and brain metastases was withdrawn.
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CLINICAL_TRIALS withdrawal · 2012-05-18Clinical Trial Update: Levetiracetam in Treating Patients With Seizures Caused by Brain Metastases [NA]
The clinical trial evaluating levetiracetam for seizures caused by brain metastases has been withdrawn.
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CLINICAL_TRIALS withdrawal · 2011-11-02Clinical Trial Update: Proton MR Spectroscopy of Brain Metastases in Evaluation of Treatment Response.
A clinical trial (NCT00184288) evaluating proton MR spectroscopy for evaluating treatment response in brain metastases has been withdrawn.