Brain Metastases
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Radiosurgery With or Without Whole Brain Radiation for Multiple Metastases
This clinical trial investigates radiosurgery with or without whole-brain radiation therapy for patients with multiple brain metastases and …
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: HER2-CAR T Cells in Treating Patients With Recurrent Brain or Leptomeningeal Metastases [Phase 1]
Phase 1 clinical trial update for HER2-directed CAR-T cells in patients with recurrent brain or leptomeningeal metastases from breast cancer…
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability [Phase 3]
Phase 3 trial evaluating whether high-dose radiation targeted to brain metastases with hippocampus-sparing approaches is better at preservin…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: Assess Use of 18F-Fluciclovine for Patients With Large Brain Metastases Treated With Staged Stereotactic Radiosurgery [Phase 1]
A Phase 1 trial is evaluating imaging with 18F-fluciclovine for patients with large brain metastases treated with staged stereotactic radios…
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: Comparison of the Therapeutic Effects of Methylprednisolone and Dexamethasone on Peritumoral Edema During Radiotherapy for Brain Metastases: [Phase 2, Phase 3]
Phase 2/Phase 3 clinical trial comparing methylprednisolone and dexamethasone for reducing peritumoral edema during radiotherapy in patients…
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: Inflammation in Primary and Secondary Malignancies of the Central Nervous System Using [C-11]-CS1P1 [Phase 2]
Phase 2 clinical trial evaluating [C-11]-CS1P1 for inflammation in primary and secondary central nervous system malignancies, currently recr…
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies [Phase 1, Phase 2]
Phase 1/2 clinical trial of S241656 in RAS/MAPK mutation-positive malignancies is currently recruiting. The study targets non-small cell lun…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Brain Radiotherapy Combined With Dalpiciclib and Endocrine Therapy in HR-Positive/HER2-Negative Advanced Breast Cancer With Brain Metastases [Phase 2]
A Phase 2 clinical trial evaluating brain radiotherapy combined with dalpiciclib and endocrine therapy for HR-positive/HER2-negative advance…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: Dose Escalation Trial of Neoadjuvant Radiosurgery for the Treatment of Metastatic Brain Tumors [EARLY_Phase 1]
Early Phase 1 dose-escalation trial evaluating neoadjuvant radiosurgery for metastatic brain tumors; the study is currently active but not r…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: NTS-WBRT in Brain Metastases [Phase 2]
A Phase 2 clinical trial evaluating NTS-WBRT for brain metastases is currently recruiting at Massachusetts General Hospital.
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Phase II Study of Pembrolizumab in Combination With Lenvatinib in Patients With TNBC, NSCLC, and Other Tumor Types and Brain Metastases [Phase 2]
A Phase II study is evaluating the combination of pembrolizumab and lenvatinib in patients with triple-negative breast cancer, non-small cel…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Blood-brain Barrier (BBB) Opening Using Exablate Focused Ultrasound With Standard of Care Treatment of NSCLC Brain Mets [Phase 3]
Phase 3 trial evaluating blood-brain barrier opening with Exablate Focused Ultrasound in combination with standard of care for brain metasta…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Phase Ib Study of AlpeliSib With PEmbroLizumab in Patients With mEtastatic Breast caNcer or melanomA (SELENA) [Phase 1]
Phase Ib study investigating alpelisib in combination with pembrolizumab in metastatic breast cancer or melanoma is currently recruiting.
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Stereotactic Radiosurgery (SRS) Dose-Escalation Study for Brain Metastasis [NA]
A dose-escalation study of stereotactic radiosurgery for brain metastases is currently active but not recruiting, sponsored by UT Southweste…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: EXCLAIM: Exploring Combined Local and Systemic Approaches In Brain Metastasis: a Multi-cohort Randomized Phase II Study Evaluating Initial Response to Systemic Therapy and Subsequent Integration of Stereotactic Radiosurgery in Patients With Low-risk Brain Metastases and Central Nervous System-active [Phase 2]
A Phase II multi-cohort randomized trial (EXCLAIM) evaluating the combination of initial systemic therapy with subsequent stereotactic radio…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: A Pilot Study to Assess the Clinical Utility of 18F-Fluciclovine (Axumin) PET-CT for Detecting True-versus Pseudo-Progression of Brain Metastases on Immunotherapy [NA]
A pilot study sponsored by MD Anderson Cancer Center to evaluate if 18F-Fluciclovine (Axumin) PET-CT can differentiate true progression from…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases [Phase 3]
A Phase III clinical trial from the Canadian Cancer Trials Group compares stereotactic radiosurgery alone with hippocampal-avoidant whole-br…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Trametinib With or Without Whole Brain Radiation Therapy in Treating Patients With Brain Metastases [Phase 1]
Phase 1 trial evaluating trametinib with or without whole brain radiation therapy for brain metastases. The study is currently active but no…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Genetic Testing in Guiding Treatment for Patients With Brain Metastases [Phase 2]
Phase 2 study evaluating whether genetic testing can guide treatment for patients with brain metastases; the trial is currently active but n…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: SRS Compared With FSRS for Treatment of Intact Metastatic Brain Disease, FRACTIONATE Trial [Phase 2]
A Phase 2 FRACTIONATE trial compares single-session stereotactic radiosurgery (SRS) with fractionated SRS (FSRS) for intact brain metastases…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: SMART Trial: Cognitive Sparing Brain Radiotherapy for Multiple Brain Metastases [Phase 2]
The SMART trial is evaluating cognitive-sparing brain radiotherapy for patients with multiple brain metastases in solid tumors. The Phase 2 …
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CLINICAL_TRIALS research · 2026-04-09Clinical Trial Update: A Phase II Study of Nivolumab With Ipilimumab and Cabozantinib in Patients With Untreated Renal Cell Carcinoma Brain Metastases [Phase 2]
This clinical trial update outlines a Phase II study of nivolumab with ipilimumab and cabozantinib in patients with untreated renal cell car…
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CLINICAL_TRIALS research · 2026-04-09Clinical Trial Update: Nitroglycerin Plus Radiotherapy Versus Conventional Radiotherapy in Patients With Lung Cancer. [NA]
A clinical trial is evaluating nitroglycerin as a radiosensitizer added to radiotherapy versus conventional radiotherapy in patients with no…
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: Delayed or Upfront Brain RAdiotherapy in Treatment naïve Lung Cancer Patients With Asymptomatic or Minimally Symptomatic Brain Metastases and ALK rEarrangements [Phase 1, Phase 2]
A phase 1/2 clinical trial is investigating optimal timing of brain radiotherapy (delayed vs upfront) in treatment‑naïve non-small cell lung…
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: Memory Avoidance Whole Brain Radiotherapy vs Hippocampal Avoidance Whole Brain Radiotherapy (Athena 2 Trial) [Phase 2]
Clinical trial comparing memory-avoidant whole-brain radiotherapy with hippocampal-avoidant whole-brain radiotherapy in patients with brain …