Brain Metastases

• CLINICAL_TRIALS trial_result · 2026-06-04
  Clinical Trial Results: Pembrolizumab and Lenvatinib in Patients With Brain Metastases From Melanoma or Renal Cell Carcinoma [Phase 2]

  Phase 2 trial evaluating pembrolizumab plus lenvatinib for brain metastases from melanoma or renal cell carcinoma; study terminated with res…

• CLINICAL_TRIALS trial_result · 2026-04-24
  Clinical Trial Update: Utility of Perfusion MRI to Detect Radiation Necrosis in Patients With Brain Metastases [NA]

  A completed clinical trial evaluating whether perfusion MRI can reliably detect radiation necrosis in patients with brain metastases.

• CLINICAL_TRIALS trial_result · 2026-04-23
  Clinical Trial Update: Prospective Study on Oncologic Cerebral Imagery Contribution by 18F-FDOPA Position Emission Tomography (PET) [NA]

  This clinical trial update notes the completion of a prospective study evaluating the contribution of 18F-FDOPA PET imaging to oncologic cer…

• CLINICAL_TRIALS trial_result · 2026-04-23
  Clinical Trial Update: Tarlatamab for SCLC Brain Metastases [Phase 2]

  Maastricht University Medical Center is conducting a Phase 2 trial of tarlatamab for adults with small cell lung cancer and brain metastases…

• CLINICAL_TRIALS trial_result · 2026-04-22
  Clinical Trial Update: GDC-0084 With Radiation Therapy for People With PIK3CA-Mutated Solid Tumor Brain Metastases or Leptomeningeal Metastases [Phase 1]

  Phase 1 study of GDC-0084 with radiation therapy in patients with PIK3CA-mutated solid tumor brain metastases or leptomeningeal metastases; …

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• CLINICAL_TRIALS trial_result · 2026-04-21
  Clinical Trial Update: Single Fraction Stereotactic Radiosurgery Compared With Fractionated Stereotactic Radiosurgery in Treating Patients With Resected Metastatic Brain Disease [Phase 3]

  A Phase 3 trial evaluating single-fraction stereotactic radiosurgery versus fractionated stereotactic radiosurgery in patients who have had …

• CLINICAL_TRIALS trial_result · 2026-04-15
  Clinical Trial Update: Sunitinib in Treating Patients With Kidney Cancer That Has Spread to the Brain [Phase 2]

  A completed Phase 2 trial evaluating sunitinib in patients with metastatic kidney cancer, including brain metastases. The update notes compl…

• CLINICAL_TRIALS trial_result · 2026-04-06
  Clinical Trial Update: Pilot Study of Nivolumab w/Ipilimumab or Relatlimab in Surgically Resectable Melanoma Brain Metastases [EARLY_Phase 1]

  A Phase 1 pilot trial evaluating nivolumab plus either ipilimumab or relatlimab for surgically resectable melanoma with brain metastases has…

• CLINICAL_TRIALS trial_result · 2026-04-01
  Clinical Trial Update: A Phase II Clinical Study of Utidelone and Bevacizumab With or Without Etoposide in Patients With Brain Metastases From Malignant Solid Tumors [Phase 2]

  A Phase II clinical study evaluating Utidelone and Bevacizumab, with or without Etoposide, in patients with brain metastases from malignant …

• CLINICAL_TRIALS trial_result · 2026-03-31
  Clinical Trial Update: Detection and Metabolic Characterization in DOPA PET/CT of Brain Metastases [NA]

  Completed clinical trial examining detection and metabolic characterization of brain metastases using DOPA PET/CT.

• CLINICAL_TRIALS trial_result · 2026-03-27
  Clinical Trial Update: Osimertinib Combined With Intracranial SRT for EGFR-Mutant NSCLC With Symptomatic Brain Metastases

  An ongoing clinical trial is evaluating osimertinib in combination with intracranial stereotactic radiotherapy for EGFR-mutant non-small cel…

• CLINICAL_TRIALS trial_result · 2026-03-25
  Clinical Trial Update: Binimetinib Encorafenib Pembrolizumab +/- Stereotactic Radiosurgery in BRAFV600 Melanoma With Brain Metastasis [Phase 2]

  A Phase 2 clinical trial evaluating a combination of binimetinib, encorafenib, and pembrolizumab, with or without stereotactic radiosurgery,…

• CLINICAL_TRIALS trial_result · 2026-03-24
  Clinical Trial Update: Analyzing Preoperative Stereotactic Radiosurgery With Gamma Knife Icon for Brain Metastases [NA]

  A completed clinical trial evaluated preoperative stereotactic radiosurgery with the Gamma Knife Icon device for brain metastases, and resul…

• CLINICAL_TRIALS trial_result · 2026-03-20
  Clinical Trial Update: Blood Brain Barrier Disruption (BBBD) Using MRgFUS in the Treatment of Her2-positive Breast Cancer Brain Metastases [NA]

  This completed clinical trial evaluated blood-brain barrier disruption using MR-guided focused ultrasound in HER2-positive breast cancer pat…

• CLINICAL_TRIALS trial_result · 2026-03-18
  Clinical Trial Update: Bintrafusp Alfa and Pimasertib for the Treatment of Patients With Brain Metastases [Phase 1, Phase 2]

  A Phase 1/2 trial evaluating Bintrafusp alfa in combination with Pimasertib for brain metastases has been terminated, with results posted in…

• CLINICAL_TRIALS trial_result · 2026-03-17
  Clinical Trial Update: Osimertinib With or Without Bevacizumab in Treating Patients With EGFR Positive Non-small Cell Lung Cancer and Brain Metastases [Phase 2]

  Phase 2 trial evaluating osimertinib with or without bevacizumab in EGFR-positive non-small cell lung cancer with brain metastases; results …

• CLINICAL_TRIALS trial_result · 2026-03-16
  Clinical Trial Update: TraStuzumAb-Radiotherapy : Impact on the Cerebral Prevention [Phase 3]

  A Phase 3 trial evaluating trastuzumab with radiotherapy to prevent brain metastases in breast cancer has been terminated.

• CLINICAL_TRIALS trial_result · 2026-03-16
  Clinical Trial Update: Prospective Assessment of Quality of Life in Patients Treated by Radiosurgery for Brain Metastases (PRAMECE-1302) [NA]

  The Prospective Assessment of Quality of Life in Patients Treated by Radiosurgery for Brain Metastases (PRAMECE-1302) trial, which evaluated…

• CLINICAL_TRIALS trial_result · 2026-03-09
  Clinical Trial Update: Pembrolizumab and Stereotactic Radiosurgery for Melanoma or Non-Small Cell Lung Cancer Brain Metastases [Phase 1]

  This phase 1 study assessed pembrolizumab in combination with stereotactic radiosurgery for patients with brain metastases from melanoma or …

• CLINICAL_TRIALS trial_result · 2026-03-06
  Clinical Trial Update: CBF and NCF Changes With Brain Radiation

  This clinical trial update discusses cerebral blood flow and neurocognitive function changes associated with brain radiation in patients wit…

• CLINICAL_TRIALS trial_result · 2026-03-04
  Clinical Trial Update: A Study of Neoadjuvant Stereotactic Radiosurgery for Large Brain Metastases [NA]

  Completed clinical trial evaluating neoadjuvant stereotactic radiosurgery for large brain metastases.

• CLINICAL_TRIALS trial_result · 2026-03-03
  Clinical Trial Update: An Interactive Time-Restricted Diet Intervention (txt4fasting) for Reducing Neurocognitive Decline and Improving Survival in Patients With Brain Metastases From Breast or Lung Cancer [NA]

  The txt4fasting trial investigating a time-restricted diet to reduce neurocognitive decline and improve survival in patients with brain meta…

• CLINICAL_TRIALS trial_result · 2026-02-20
  Clinical Trial Update: REMASTer: REcurrent Brain Metastases After SRS Trial [NA]

  A clinical trial named REMASTer (REcurrent Brain Metastases After SRS Trial) sponsored by Monteris Medical is currently recruiting. It studi…

• CLINICAL_TRIALS trial_result · 2026-02-12
  Clinical Trial Update: Fractionated Stereotactic Radiotherapy for Limited Small Volume Brain Metastases [NA]

  The completed clinical trial evaluated fractionated stereotactic radiotherapy for limited small-volume brain metastases. It was sponsored by…

• CLINICAL_TRIALS trial_result · 2026-02-10
  Clinical Trial Update: Keto-Brain:Investigating the Use of Ketogenic Diets in Brain Metastases [NA]

  A clinical trial evaluating ketogenic diets for brain metastases has been suspended, with recruitment halted for now.