Brain Metastases
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-10-07Clinical Trial Update: Post-Surgical Stereotactic Radiotherapy (SRT) Versus GammaTile-ROADS (Radiation One and Done Study) [Phase 3]
Phase 3 study comparing post-surgical stereotactic radiotherapy (SRT) to GammaTile-ROADS for brain metastases; status indicates the trial is…
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CLINICAL_TRIALS research · 2025-10-01Clinical Trial Update: A First-In-Human, Phase 1 Study Evaluating Oral TACC3 PPI Inhibitor, AO-252, in Advanced Solid Tumors With or Without Brain Metastases [Phase 1]
This update describes the first-in-human Phase 1 trial of AO-252, an oral TACC3 protein-protein interaction inhibitor, in patients with adva…
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CLINICAL_TRIALS research · 2025-10-01Clinical Trial Update: Encorafenib and biNimetinib Followed by CEmiplimab and FiAnLimab in Patients With BRAF Mutant melanOma and Symptomatic Brain Metastases [Phase 2]
A Phase 2 clinical trial evaluating initial therapy with encorafenib and binimetinib followed by cemiplimab and fianlimab in patients with B…
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CLINICAL_TRIALS research · 2025-09-30Clinical Trial Update: AI-assisted Diagnosis of Malignant Brain Tumors
An AI-assisted diagnostic study for malignant brain tumors is currently recruiting at Zhejiang University. The trial focuses on leveraging A…
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CLINICAL_TRIALS trial_result · 2025-09-30Clinical Trial Update: Allogeneic, Antigen-Presenting, GM-CSF-secreting, SV-BR-1-GM Whole Cell-Therapeutic Vaccine and Immunotherapy: A Phase I Pilot Safety and Feasibility Study for Solid Tumor Patients With CNS Metastases [Phase 1]
A Phase I pilot safety and feasibility study of the SV-BR-1-GM whole-cell vaccine for solid tumors with CNS metastases (brain metastases and…
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CLINICAL_TRIALS research · 2025-09-29Clinical Trial Update: ioMRI in the Surgery of Brain Metastases. [NA]
An ongoing clinical trial is evaluating the use of intraoperative MRI (ioMRI) to guide surgery for brain metastases at the Technical Univers…
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CLINICAL_TRIALS trial_result · 2025-09-29Clinical Trial Update: Sacituzumab Tirumotecan (Sac-TMT) Plus Bevacizumab in 3rd Generation EGFR-TKI Treated Advanced EGFR-mutant Nonsquamous NSCLC With Brain Metastasis [Phase 2]
This Phase 2 trial evaluates sacituzumab tirumotecan plus bevacizumab in advanced EGFR-mutant nonsquamous non-small cell lung cancer with br…
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CLINICAL_TRIALS research · 2025-09-29Clinical Trial Update: A Single Arm, Phase 2 Study of Datopotamab Deruxtecan, Carboplatin, and Pembrolizumab for Treatment-naive Brain Metastases From NSCLC (Non-small Cell Lung Cancer) [Phase 2]
Phase 2 single-arm trial evaluating the combination of Datopotamab Deruxtecan, carboplatin, and pembrolizumab for treatment-naive brain meta…
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CLINICAL_TRIALS research · 2025-09-24Clinical Trial Update: Study Comparing Investigational Drug HBI-8000 + Nivolumab vs. Placebo + Nivolumab in Patients With Advanced Melanoma [Phase 3]
A Phase 3 trial is evaluating HBI-8000 plus nivolumab versus placebo plus nivolumab in advanced unresectable or metastatic melanoma, includi…
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CLINICAL_TRIALS trial_result · 2025-09-24Clinical Trial Update: HyperArc Registry Study
The HyperArc Registry Study sponsored by Varian (a Siemens Healthineers company) has completed, evaluating HyperArc for brain metastases and…
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CLINICAL_TRIALS research · 2025-09-23Clinical Trial Update: Mechanistic Study of SPARC-Mediated Regulation of Neutrophil Extracellular Trap Formation in the Brain Metastatic Microenvironment of Breast Cancer
A mechanistic study investigating SPARC's regulation of neutrophil extracellular trap formation in the brain metastasis microenvironment of …
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CLINICAL_TRIALS research · 2025-09-22Clinical Trial Update: Dual Energy CT - a Tool for Delineation of Tumor and Organs at Risk in Radiotherapy
A clinical trial evaluating Dual Energy CT to delineate tumors and organs at risk in radiotherapy planning; the study is not yet recruiting.
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CLINICAL_TRIALS research · 2025-09-19Clinical Trial Update: MRI Biomarkers for Radiation-Induced Neurocognitive Decline Following SRS of Newly Diagnosed Brain Mets
This clinical trial investigates MRI biomarkers of radiation-induced neurocognitive decline following stereotactic radiosurgery for newly di…
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CLINICAL_TRIALS research · 2025-09-17Clinical Trial Update: A Two-cohort Study of SHR-A1811 in the Treatment of HER2-positive Breast Cancer With Brain Metastases [Phase 1, Phase 2]
This is a two-cohort Phase 1/Phase 2 study evaluating SHR-A1811 for HER2-positive breast cancer with brain metastases.
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CLINICAL_TRIALS research · 2025-09-17Clinical Trial Update: Arginine and Whole Brain Radiation Therapy for the Treatment of Patients With Brain Metastases [EARLY_Phase 1]
A phase 1 trial is evaluating arginine in combination with whole-brain radiation therapy for brain metastases and is currently recruiting.
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CLINICAL_TRIALS research · 2025-09-15Clinical Trial Update: SRS for NSCLC With Oligo-residual Intracranial Disease After First-line 3rd Generation EGFR-TKI [Phase 2]
Clinical trial update on stereotactic radiosurgery for brain metastases in non-small cell lung cancer after a first-line third-generation EG…
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CLINICAL_TRIALS research · 2025-09-11Clinical Trial Update: Evolution of Hypofractionated Stereotactic Irradiation for Radio-Resistant Brain Metastases From D1-3-5 to D1-2-3 [Phase 3]
A Phase 3 trial update evaluating hypofractionated stereotactic irradiation for radio-resistant brain metastases, evolving from a D1-3-5 reg…
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CLINICAL_TRIALS research · 2025-09-10Clinical Trial Update: Observation or Upfront Cranial RT in Oncogene Mutated NSCLC With Asymptomatic BM: A Phase III RCT [Phase 3]
A Phase III randomized trial is evaluating upfront cranial radiotherapy versus observation in patients with oncogene-mutated non-small cell …
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CLINICAL_TRIALS trial_result · 2025-09-10Clinical Trial Update: First Line Treatment in EGFR Mutation Positive Advanced NSCLC Patients With Central Nervous System (CNS) Metastases [Phase 2, Phase 3]
Clinical trial update indicating the completion of a Phase 2/3 study evaluating first-line treatment for EGFR mutation-positive advanced non…
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CLINICAL_TRIALS research · 2025-09-09Clinical Trial Update: Combined Gamma Knife/Linac Radiosurgery for Large Brain Tumors / Metastases [Phase 2]
ClinicalTrials.gov entry describing a Phase 2 study evaluating combined Gamma Knife and Linac radiosurgery for large brain tumors and brain …
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CLINICAL_TRIALS research · 2025-09-08Clinical Trial Update: Trial of Relatlimab, Nivolumab, and Ipilimumab in Patients With Asymptomatic and Symptomatic Melanoma Brain Metastases [Phase 2]
Phase 2 trial assessing a triple combination of relatlimab, nivolumab, and ipilimumab in patients with asymptomatic and symptomatic melanoma…
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CLINICAL_TRIALS research · 2025-09-05Clinical Trial Update: Pre-operative SRS or Post-operative SRS in Treating Cancer Patients With Brain Metastases [Phase 3]
Phase 3 trial evaluating pre-operative versus post-operative stereotactic radiosurgery for brain metastases; currently recruiting.
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CLINICAL_TRIALS research · 2025-09-03Clinical Trial Update: Feasibility of 18F-Fluciclovine PET/CT to Identify Brain Metastasis [Phase 2]
A Phase 2 feasibility trial at the University of Arizona is evaluating the radiotracer 18F-Fluciclovine PET/CT to identify brain metastases.
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CLINICAL_TRIALS trial_result · 2025-08-28Clinical Trial Update: Study to Establish the Diagnostic Performance of 18F Fluciclovine PET in Detecting Recurrent Brain Metastases [Phase 3]
A Phase 3 study evaluating the diagnostic performance of 18F-fluciclovine PET for detecting recurrent brain metastases has completed and pos…
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CLINICAL_TRIALS trial_result · 2025-08-20Clinical Trial Update: Magnetic Resonance-Guided Laser Interstitial Thermal Therapy for Brain Metastases Trial [NA]
A clinical trial evaluating magnetic resonance-guided laser interstitial thermal therapy for brain metastases has completed.