Brain Metastases
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-06-04Clinical Trial Results: Pembrolizumab and Lenvatinib in Patients With Brain Metastases From Melanoma or Renal Cell Carcinoma [Phase 2]
Phase 2 trial evaluating pembrolizumab plus lenvatinib for brain metastases from melanoma or renal cell carcinoma; study terminated with res…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Radiosurgery With or Without Whole Brain Radiation for Multiple Metastases
This clinical trial investigates radiosurgery with or without whole-brain radiation therapy for patients with multiple brain metastases and …
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CLINICAL_TRIALS trial_result · 2026-04-24Clinical Trial Update: Utility of Perfusion MRI to Detect Radiation Necrosis in Patients With Brain Metastases [NA]
A completed clinical trial evaluating whether perfusion MRI can reliably detect radiation necrosis in patients with brain metastases.
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: HER2-CAR T Cells in Treating Patients With Recurrent Brain or Leptomeningeal Metastases [Phase 1]
Phase 1 clinical trial update for HER2-directed CAR-T cells in patients with recurrent brain or leptomeningeal metastases from breast cancer…
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability [Phase 3]
Phase 3 trial evaluating whether high-dose radiation targeted to brain metastases with hippocampus-sparing approaches is better at preservin…
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CLINICAL_TRIALS trial_result · 2026-04-23Clinical Trial Update: Prospective Study on Oncologic Cerebral Imagery Contribution by 18F-FDOPA Position Emission Tomography (PET) [NA]
This clinical trial update notes the completion of a prospective study evaluating the contribution of 18F-FDOPA PET imaging to oncologic cer…
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CLINICAL_TRIALS trial_result · 2026-04-23Clinical Trial Update: Tarlatamab for SCLC Brain Metastases [Phase 2]
Maastricht University Medical Center is conducting a Phase 2 trial of tarlatamab for adults with small cell lung cancer and brain metastases…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: Assess Use of 18F-Fluciclovine for Patients With Large Brain Metastases Treated With Staged Stereotactic Radiosurgery [Phase 1]
A Phase 1 trial is evaluating imaging with 18F-fluciclovine for patients with large brain metastases treated with staged stereotactic radios…
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CLINICAL_TRIALS trial_result · 2026-04-22Clinical Trial Update: GDC-0084 With Radiation Therapy for People With PIK3CA-Mutated Solid Tumor Brain Metastases or Leptomeningeal Metastases [Phase 1]
Phase 1 study of GDC-0084 with radiation therapy in patients with PIK3CA-mutated solid tumor brain metastases or leptomeningeal metastases; …
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CLINICAL_TRIALS trial_result · 2026-04-21Clinical Trial Update: Single Fraction Stereotactic Radiosurgery Compared With Fractionated Stereotactic Radiosurgery in Treating Patients With Resected Metastatic Brain Disease [Phase 3]
A Phase 3 trial evaluating single-fraction stereotactic radiosurgery versus fractionated stereotactic radiosurgery in patients who have had …
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: Comparison of the Therapeutic Effects of Methylprednisolone and Dexamethasone on Peritumoral Edema During Radiotherapy for Brain Metastases: [Phase 2, Phase 3]
Phase 2/Phase 3 clinical trial comparing methylprednisolone and dexamethasone for reducing peritumoral edema during radiotherapy in patients…
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: Inflammation in Primary and Secondary Malignancies of the Central Nervous System Using [C-11]-CS1P1 [Phase 2]
Phase 2 clinical trial evaluating [C-11]-CS1P1 for inflammation in primary and secondary central nervous system malignancies, currently recr…
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies [Phase 1, Phase 2]
Phase 1/2 clinical trial of S241656 in RAS/MAPK mutation-positive malignancies is currently recruiting. The study targets non-small cell lun…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Brain Radiotherapy Combined With Dalpiciclib and Endocrine Therapy in HR-Positive/HER2-Negative Advanced Breast Cancer With Brain Metastases [Phase 2]
A Phase 2 clinical trial evaluating brain radiotherapy combined with dalpiciclib and endocrine therapy for HR-positive/HER2-negative advance…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: Dose Escalation Trial of Neoadjuvant Radiosurgery for the Treatment of Metastatic Brain Tumors [EARLY_Phase 1]
Early Phase 1 dose-escalation trial evaluating neoadjuvant radiosurgery for metastatic brain tumors; the study is currently active but not r…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: NTS-WBRT in Brain Metastases [Phase 2]
A Phase 2 clinical trial evaluating NTS-WBRT for brain metastases is currently recruiting at Massachusetts General Hospital.
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Phase II Study of Pembrolizumab in Combination With Lenvatinib in Patients With TNBC, NSCLC, and Other Tumor Types and Brain Metastases [Phase 2]
A Phase II study is evaluating the combination of pembrolizumab and lenvatinib in patients with triple-negative breast cancer, non-small cel…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Blood-brain Barrier (BBB) Opening Using Exablate Focused Ultrasound With Standard of Care Treatment of NSCLC Brain Mets [Phase 3]
Phase 3 trial evaluating blood-brain barrier opening with Exablate Focused Ultrasound in combination with standard of care for brain metasta…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Phase Ib Study of AlpeliSib With PEmbroLizumab in Patients With mEtastatic Breast caNcer or melanomA (SELENA) [Phase 1]
Phase Ib study investigating alpelisib in combination with pembrolizumab in metastatic breast cancer or melanoma is currently recruiting.
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Stereotactic Radiosurgery (SRS) Dose-Escalation Study for Brain Metastasis [NA]
A dose-escalation study of stereotactic radiosurgery for brain metastases is currently active but not recruiting, sponsored by UT Southweste…
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CLINICAL_TRIALS trial_result · 2026-04-15Clinical Trial Update: Sunitinib in Treating Patients With Kidney Cancer That Has Spread to the Brain [Phase 2]
A completed Phase 2 trial evaluating sunitinib in patients with metastatic kidney cancer, including brain metastases. The update notes compl…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: EXCLAIM: Exploring Combined Local and Systemic Approaches In Brain Metastasis: a Multi-cohort Randomized Phase II Study Evaluating Initial Response to Systemic Therapy and Subsequent Integration of Stereotactic Radiosurgery in Patients With Low-risk Brain Metastases and Central Nervous System-active [Phase 2]
A Phase II multi-cohort randomized trial (EXCLAIM) evaluating the combination of initial systemic therapy with subsequent stereotactic radio…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: A Pilot Study to Assess the Clinical Utility of 18F-Fluciclovine (Axumin) PET-CT for Detecting True-versus Pseudo-Progression of Brain Metastases on Immunotherapy [NA]
A pilot study sponsored by MD Anderson Cancer Center to evaluate if 18F-Fluciclovine (Axumin) PET-CT can differentiate true progression from…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases [Phase 3]
A Phase III clinical trial from the Canadian Cancer Trials Group compares stereotactic radiosurgery alone with hippocampal-avoidant whole-br…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Trametinib With or Without Whole Brain Radiation Therapy in Treating Patients With Brain Metastases [Phase 1]
Phase 1 trial evaluating trametinib with or without whole brain radiation therapy for brain metastases. The study is currently active but no…