Brain Metastases
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2025-12-04Clinical Trial Update: Preoperative Stereotactic Radiosurgery for Brain Metastases [Phase 2]
Phase 2 clinical trial evaluating preoperative stereotactic radiosurgery for brain metastases has completed.
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CLINICAL_TRIALS research · 2025-12-03Clinical Trial Update: Defactinib and Avutometinib, With or Without Encorafenib, for the Treatment of Patients With Brain Metastases From Cutaneous Melanoma [Phase 1, Phase 2]
An ongoing Phase 1/2 clinical trial evaluating defactinib and avutometinib, with or without encorafenib, in patients with brain metastases f…
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CLINICAL_TRIALS research · 2025-12-03Clinical Trial Update: A Study of 68Ga-PSMA-11 PET Scans in People With Brain Tumors [EARLY_Phase 1]
Early-phase clinical trial studying Gallium-68 PSMA-11 PET imaging for patients with brain tumors, currently active but not recruiting.
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CLINICAL_TRIALS research · 2025-12-02Clinical Trial Update: 7T Brain MRI Scan for Micro-brain Metastasis (microBM) Detection for Patients With Small-cell Lung Cancer (SCLC), Who Decline Prophylactic Cranial Irradiation (PCI)
A clinical trial evaluating the use of 7T brain MRI to detect micro-brain metastases in small-cell lung cancer patients who decline prophyla…
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CLINICAL_TRIALS research · 2025-12-02Clinical Trial Update: FSRT Combines With Bevacizumab for Multiple Brain Metastases in Lung Adenocarcinoma [Phase 3]
A Phase 3 clinical trial is evaluating the combination of fractionated stereotactic radiotherapy (FSRT) with bevacizumab for patients with m…
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CLINICAL_TRIALS research · 2025-12-01Clinical Trial Update: Characterization of 18F-Fluciclovine PET Amino Acid Radiotracer in Resected Brain Metastasis [Phase 2]
Phase 2 study characterizing the use of the radiotracer 18F-fluciclovine PET to evaluate resected brain metastases and brain cancer.
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CLINICAL_TRIALS research · 2025-11-28Clinical Trial Update: A Pivotal Phase II Clinical Trial of Utidelone Injection Plus Capecitabine in HER2-negative Breast Cancer Patients With Brain Metastases [Phase 2]
This clinical trial is evaluating Utidelone injection plus capecitabine in HER2-negative breast cancer patients with brain metastases in Pha…
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CLINICAL_TRIALS research · 2025-11-25Clinical Trial Update: Testing of the Anti Cancer Drugs CB-839 HCl (Telaglenastat) and MLN0128 (Sapanisertib) in Advanced Stage Non-small Cell Lung Cancer [Phase 1]
Phase 1 clinical trial update testing Telaglenastat and Sapanisertib in advanced non-small cell lung cancer with brain and leptomeningeal me…
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CLINICAL_TRIALS research · 2025-11-24Clinical Trial Update: Phase 2b Imaging Study of RAD101 in Participants With Suspected Recurrent Brain Metastases [Phase 2]
Phase 2b imaging study of RAD101 for suspected recurrent brain metastases is currently recruiting.
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CLINICAL_TRIALS trial_result · 2025-11-24Clinical Trial Update: Evaluation of the Humoral and Tumoral Molecular Alteration Profile of Brain Metastases [NA]
This clinical trial update reports the completed evaluation of humoral and tumoral molecular alterations in brain metastases.
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CLINICAL_TRIALS research · 2025-11-24Clinical Trial Update: Brain [18F]-FES PET/CT in Patients With Estrogen-Receptor Positive Breast Cancer [Phase 4]
Phase 4 clinical trial updating on the use of the PET tracer [18F]-FES to image estrogen receptor–positive breast cancer with brain metastas…
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CLINICAL_TRIALS research · 2025-11-19Clinical Trial Update: A Randomized Phase II Study Evaluating Upfront SRT to All Brain Metastases Followed by Ivonescimab Plus Chemotherapy Versus Upfront Ivonescimab Plus Chemotherapy in Patients With Asymptomatic Active Brain Metastases From NSCLC [Phase 2]
A randomized Phase II trial evaluates upfront stereotactic radiotherapy to all brain metastases followed by Ivonescimab plus chemotherapy ve…
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CLINICAL_TRIALS research · 2025-11-19Clinical Trial Update: Circulating Biomarkers Repository in Adults Diagnosed With Primary and Metastatic Brain Tumors
This study aims to collect circulating biomarkers from adults with primary brain tumors and brain metastases to build a biomarker repository…
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CLINICAL_TRIALS trial_result · 2025-11-18Clinical Trial Update: Dynamic F-DOPA PET for Differential Diagnosis Between Recurrence and Radionecrosis of Brain Metastasis [NA]
Completed clinical trial evaluating dynamic F-DOPA PET to differentiate recurrence from radionecrosis in patients with brain metastases.
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CLINICAL_TRIALS research · 2025-11-18Clinical Trial Update: Electrocorticography in Mapping Functional Brain Areas During Surgery in Patients With Brain Tumors [NA]
An MD Anderson Cancer Center trial is recruiting to evaluate electrocorticography for mapping functional brain areas during brain tumor surg…
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CLINICAL_TRIALS trial_result · 2025-11-17Clinical Trial Update: Treatment With Tucatinib in Patients With an Isolated Brain Progression of a Metastatic Breast Cancer [Phase 2]
Phase 2 trial evaluating tucatinib for metastatic breast cancer with isolated brain progression. The study status is active but not recruiti…
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CLINICAL_TRIALS research · 2025-11-14Clinical Trial Update: A Study of Cabozantinib and Nivolumab With Radiation Therapy for People With Renal Cell Carcinoma That Has Spread to the Brain [Phase 1]
Phase 1 study evaluating the combination of cabozantinib and nivolumab with radiation therapy for metastatic renal cell carcinoma with brain…
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CLINICAL_TRIALS research · 2025-11-13Clinical Trial Update: Stereotactic Magnetic Resonance Guided Radiation Therapy [NA]
Clinical trial update on stereotactic MR-guided radiation therapy for multiple cancer types; recruitment is ongoing.
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CLINICAL_TRIALS research · 2025-11-10Clinical Trial Update: Personalized Radiotherapy for Individualized Treatment Strategies and Monitoring (PRISM) [Phase 1]
Phase 1 trial PRISM investigates personalized radiotherapy for extensive-stage small cell lung cancer with brain metastases; recruitment is …
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CLINICAL_TRIALS research · 2025-11-10Clinical Trial Update: Nivolumab and Radiation Therapy With or Without Ipilimumab in Treating Patients With Brain Metastases From Non-small Cell Lung Cancer [Phase 1, Phase 2]
Phase 1/2 clinical trial evaluating nivolumab with radiation therapy, with or without ipilimumab, for brain metastases arising from non-smal…
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CLINICAL_TRIALS trial_result · 2025-10-31Clinical Trial Update: Pivotal, Open-label, Randomized Study of Radiosurgery With or Without Tumor Treating Fields (TTFields) for 1-10 Brain Metastases From Non-small Cell Lung Cancer (NSCLC). [Phase 3]
A pivotal Phase 3 trial evaluated adding Tumor Treating Fields (TTFields) to radiosurgery for patients with 1-10 brain metastases from non-s…
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CLINICAL_TRIALS trial_result · 2025-10-15Clinical Trial Update: MW151 and Whole-brain Radiotherapy in Patients With Intracranial Metastases [Phase 1]
Phase 1 trial update of MW151 in combination with whole-brain radiotherapy for patients with brain metastases, focusing on cognitive outcome…
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CLINICAL_TRIALS research · 2025-10-15Clinical Trial Update: Trial of Differential Margins in Single Isocenter Radiosurgery of Brain Metastases [NA]
A clinical trial update for a radiation therapy study on differential margins in single isocenter radiosurgery for brain metastases; the stu…
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CLINICAL_TRIALS research · 2025-10-08Clinical Trial Update: S1501 Dual Observational and Randomized Cohort Study of Patients With Metastatic HER-2+ Breast Cancer at Risk of Cardiac Toxicity [Phase 3]
Phase 3 dual observational and randomized cohort study (S1501) evaluating patients with metastatic HER2-positive breast cancer at risk of ca…
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CLINICAL_TRIALS trial_result · 2025-10-08Clinical Trial Update: CALM: Managing Distress in Malignant Brain Cancer [NA]
This document reports a completed update for the CALM trial focused on managing distress in patients with malignant brain cancer.