Brain Metastases

• CLINICAL_TRIALS trial_result · 2018-04-17
  Clinical Trial Update: Temozolomide in Treating Patients With Primary Brain Tumors or Metastatic Brain Tumors [Phase 1]

  A Phase 1 trial evaluating temozolomide for patients with primary brain tumors or brain metastases has been completed.

• CLINICAL_TRIALS trial_result · 2018-04-17
  Clinical Trial Update: Bafetinib in Treating Patients With Recurrent High-Grade Glioma or Brain Metastases [Phase 1]

  This Phase 1 trial assessing bafetinib in adults with recurrent high-grade glioma or brain metastases has completed.

• CLINICAL_TRIALS trial_result · 2018-02-28
  Clinical Trial Update: Intrathecal Pertuzumab and Trastuzumab in Patients With New Untreated Asymptomatic or Low Symptomatic Brain Metastasis in HER2 Positive Breast Cancer [Phase 1]

  Clinical trial update for intrathecal pertuzumab and trastuzumab in HER2-positive breast cancer with brain metastases; this Phase 1 study ha…

• CLINICAL_TRIALS research · 2018-02-28
  Clinical Trial Update: Pharmacokinetics of Systemic Anti-Cancer Therapies in the Cerebrospinal Fluid (CSF) of Patients With Advanced Cancer

  This clinical trial update describes pharmacokinetic measurements of systemic anti-cancer therapies in the cerebrospinal fluid of patients w…

• CLINICAL_TRIALS trial_result · 2018-02-14
  Clinical Trial Update: Comparison of Veliparib and Whole Brain Radiation Therapy (WBRT) Versus Placebo and WBRT in Adults With Brain Metastases From Non-Small Cell Lung Cancer [Phase 2]

  A Phase 2 trial comparing veliparib plus whole-brain radiation therapy to placebo plus whole-brain radiation therapy in adults with brain me…

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• CLINICAL_TRIALS trial_result · 2018-01-19
  Clinical Trial Update: Ipilimumab Induction in Patients With Melanoma Brain Metastases Receiving Stereotactic Radiosurgery [Phase 2]

  Phase 2 trial update on ipilimumab induction in melanoma patients with brain metastases undergoing stereotactic radiosurgery; study terminat…

• CLINICAL_TRIALS trial_result · 2017-12-11
  Clinical Trial Update: Apatinib Plus Radiotherapy for Patients With Brain Metastases From Non-small-cell Lung Cancer [Phase 2]

  A Phase 2 clinical trial is evaluating the combination of apatinib with radiotherapy for brain metastases in patients with non-small cell lu…

• CLINICAL_TRIALS research · 2017-12-11
  Clinical Trial Update: PET/CT Evaluation of Primary and Metastatic Brain Tumors With a Novel Radioiodinated Phospholipid Ether Analogue I-NM404 [NA]

  Clinical trial evaluating PET/CT imaging using I-NM404 for glioblastoma multiforme and brain metastases; study completed with results posted…

• CLINICAL_TRIALS trial_result · 2017-12-08
  Clinical Trial Update: Hippocampus-sparing WBRT and Simultaneous Integrated Boost for Multiple Brain Metastases From NSCLC [Phase 2]

  This Phase 2 trial investigates hippocampus-sparing whole-brain radiotherapy with a simultaneous integrated boost for brain metastases from …

• CLINICAL_TRIALS trial_result · 2017-11-21
  Clinical Trial Update: A Phase I Study of ABT-888 in Combination With Conventional Whole Brain Radiation Therapy (WBRT) in Cancer Patients With Brain Metastases [Phase 1]

  Phase I clinical trial evaluating ABT-888 (veliparib) in combination with whole-brain radiation therapy for patients with brain metastases h…

• CLINICAL_TRIALS trial_result · 2017-11-09
  Clinical Trial Update: FSRT Combined With TMZ for Large BMs: a PSM Study

  This completed clinical trial evaluates the combination of fractionated stereotactic radiotherapy (FSRT) with temozolomide (TMZ) for large b…

• CLINICAL_TRIALS trial_result · 2017-11-06
  Clinical Trial Update: Irinotecan and Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases From Solid Tumors [Phase 1, Phase 2]

  A Phase 1/2 clinical trial evaluated the combination of irinotecan with whole-brain radiation therapy in patients with brain metastases from…

• CLINICAL_TRIALS trial_result · 2017-10-17
  Clinical Trial Update: A Study Of Everolimus, Trastuzumab And Vinorelbine In HER2-Positive Breast Cancer Brain Metastases [Phase 2]

  Phase 2 study of everolimus, trastuzumab, and vinorelbine in HER2-positive breast cancer with brain metastases has completed with posted res…

• CLINICAL_TRIALS trial_result · 2017-10-12
  Clinical Trial Update: Proteome-based Immunotherapy of Lung Cancer Brain Metastases [Phase 2, Phase 3]

  This update covers a proteome-based immunotherapy trial for brain metastases arising from lung cancer, conducted in Phase 2 and Phase 3.

• CLINICAL_TRIALS trial_result · 2017-09-27
  Clinical Trial Update: Avoiding the Hippocampus During Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases [Phase 2]

  Phase 2 clinical trial evaluating hippocampal-sparing during whole-brain radiation therapy for brain metastases; study completed with result…

• CLINICAL_TRIALS trial_result · 2017-09-20
  Clinical Trial Update: Evaluation of Repeated Whole Brain Radiotherapy Versus Best Supportive Care for Multiple Brain Metastases. [Phase 2]

  Phase 2 trial comparing repeated whole brain radiotherapy to best supportive care for patients with brain metastases.

• CLINICAL_TRIALS research · 2017-08-22
  Clinical Trial Update: A Study of the Gene Mutation Status in Cerebrospinal Fluid, Blood and Tumor Tissue of Non-small Cell Lung Cancer Patients With Brain Metastases

  This clinical trial update outlines a study assessing gene mutation status in cerebrospinal fluid, blood, and tumor tissue from patients wit…

• CLINICAL_TRIALS trial_result · 2017-08-18
  Clinical Trial Update: Fractionated Stereotactic Radiosurgery With Concurrent Bevacizumab for Brain Metastases: A Phase I Dose-escalation Trial [Phase 1]

  Phase I dose-escalation study evaluating the safety and feasibility of combining fractionated stereotactic radiosurgery with bevacizumab for…

• CLINICAL_TRIALS trial_result · 2017-07-21
  Clinical Trial Update: Memantine in Preventing Side Effects in Patients Undergoing Whole-Brain Radiation Therapy for Brain Metastases From Solid Tumors [Phase 3]

  Phase 3 trial evaluating memantine to prevent cognitive/functional side effects in patients with brain metastases undergoing whole-brain rad…

• CLINICAL_TRIALS trial_result · 2017-07-17
  Clinical Trial Update: Sorafenib Tosylate and Stereotactic Radiosurgery in Treating Patients With Brain Metastases [Phase 1]

  A Phase 1 trial evaluating sorafenib tosylate in combination with stereotactic radiosurgery for brain metastases has completed.

• CLINICAL_TRIALS trial_result · 2017-07-07
  Clinical Trial Update: Liposomal Cytarabine and High-Dose Methotrexate in Treating Patients With Central Nervous System Metastases From Breast Cancer [Phase 2]

  Phase II trial evaluating liposomal cytarabine with high-dose methotrexate for central nervous system metastases from breast cancer; the stu…

• CLINICAL_TRIALS trial_result · 2017-07-02
  Clinical Trial Update: Gene Therapy for the Treatment of Brain Tumors [Phase 1]

  Phase 1 gene therapy trial for brain tumors has completed.

• CLINICAL_TRIALS trial_result · 2017-06-06
  Clinical Trial Update: Stereotactic Radiotherapy Plus Temozolomide for Refractory Brain Metastases [Phase 2]

  A Phase 2 trial evaluating stereotactic radiotherapy plus temozolomide for refractory brain metastases has completed. The trial was conducte…

• CLINICAL_TRIALS research · 2017-06-01
  Clinical Trial Update: PCI in Advanced Triple Negative Breast Cancer Patients Who Response to 1st Line Chemotherapy [NA]

  This document provides a clinical trial update on the use of prophylactic cranial irradiation in advanced triple-negative breast cancer pati…

• CLINICAL_TRIALS trial_result · 2017-05-23
  Clinical Trial Update: Study of Temozolomide in the Treatment of Brain Metastasis From Non-small-cell Lung Cancer (Study P02143) [Phase 2]

  Phase 2 study P02143 evaluating temozolomide for brain metastases from non-small-cell lung cancer has been terminated. The sponsor is Merck …