Brain Metastases
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-01-29Clinical Trial Update: Advanced Diffusion MRI to Differentiate Tumor Recurrence From Pseudoprogression in Patients With Glioblastoma and Brain Metastases [NA]
This clinical trial update describes a study using advanced diffusion MRI to differentiate tumor recurrence from pseudoprogression in gliobl…
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CLINICAL_TRIALS research · 2025-01-28Clinical Trial Update: Heterogeneity of 68Ga-FAPI Uptake As Imaging Biomarker in T-DXd Treatment for Brain Metastasis of HER2 Positive Breast Cancer [Phase 2]
A Phase 2 trial from Fudan University is exploring heterogeneity in 68Ga-FAPI uptake as an imaging biomarker for brain metastases in HER2-po…
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CLINICAL_TRIALS research · 2025-01-27Clinical Trial Update: BrAin Metastasis in tripLe Negateive Breast Cancer: IvoneScimab and Trop2 ADC [Phase 2]
Phase 2 clinical trial update for IvoneScimab in combination with a Trop2-targeted antibody-drug conjugate for brain metastases in patients …
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CLINICAL_TRIALS trial_result · 2025-01-22Clinical Trial Update: Keynatinib in Treated Patients With NSCLC and Brain Metastases [Phase 2]
Phase 2 trial of Keynatinib in previously treated non-small cell lung cancer with brain metastases has completed; the update does not detail…
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CLINICAL_TRIALS research · 2025-01-20Clinical Trial Update: MRI Screening Versus SYMptom-directed Surveillance for Brain Metastases Among Patients with Triple Negative or HER2+ MBC [NA]
This clinical trial compares MRI screening to symptom-directed surveillance for brain metastases in patients with triple-negative or HER2-po…
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CLINICAL_TRIALS trial_result · 2025-01-15Clinical Trial Update: Feasibility of the LUM Imaging System for Detection of Cancer to the Brain [NA]
A feasibility trial of the LUM Imaging System for detecting cancer in the brain has been terminated.
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CLINICAL_TRIALS research · 2024-12-31Clinical Trial Update: Cryoablation of Brain Neoplasm [NA]
An Erasmus Medical Center-sponsored clinical trial is evaluating cryoablation for brain neoplasms, currently enrolling by invitation. The co…
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CLINICAL_TRIALS trial_result · 2024-12-30Clinical Trial Update: Study of TY-9591 in Patients With a Lung Cancer With Brain or Leptomeningeal Metastases With EGFR Mutation [Phase 2]
A Phase 2 trial of TY-9591 in non-small cell lung cancer with EGFR activating mutation and brain or leptomeningeal metastases has completed.
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CLINICAL_TRIALS withdrawal · 2024-12-20Clinical Trial Update: Durvalumab (MEDI4736) and Radiosurgery (fSRT Vs. PULSAR) for the Treatment of Non-Small Cell Lung Cancer Brain Metastases [Phase 2]
A Phase 2 trial evaluating durvalumab with radiosurgery for brain metastases from non-small cell lung cancer has been withdrawn.
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CLINICAL_TRIALS trial_result · 2024-12-12Clinical Trial Update: MR-Linac Guided Adaptive FSRT for Brain Metastases From Non-small Cell Lung Cancer [Phase 2]
Completed Phase 2 trial evaluating MR-Linac guided adaptive FSRT for brain metastases in non-small cell lung cancer.
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CLINICAL_TRIALS research · 2024-12-11Clinical Trial Update: Evaluation of the Efficacy and Safety of Furmonertinib Combined with Bevacizumab As First-Line Treatment for EGFR-Positive Non-Small Cell Lung Cancer with Brain Metastases: a Single-Arm, Open-Label, Prospective Phase II Clinical Study [Phase 2]
Phase II single-arm study evaluating furmonertinib plus bevacizumab as first-line therapy for EGFR-mutant non-small cell lung cancer with br…
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CLINICAL_TRIALS research · 2024-12-11Clinical Trial Update: Measuring and Mapping Cognitive Decline After Brain Radiosurgery
A University of Nottingham-led clinical trial is recruiting to measure and map cognitive decline after brain radiosurgery in patients with b…
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CLINICAL_TRIALS research · 2024-12-11Clinical Trial Update: Study Investigating the Role of Routine Screening and Molecular Characterisation of Brain Metastasis in the Management of High-risk Metastatic Breast Cancer
Monash University is conducting a study on routine screening and molecular characterization of brain metastases to guide management of high-…
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CLINICAL_TRIALS research · 2024-12-10Clinical Trial Update: Adebrelimab Plus Apatinib and Etoposide for the Treatment of HER2-Negative Breast Cancer Brain Metastasis [Phase 2]
Phase 2 clinical trial examining a triple-drug regimen (adebrelimab, apatinib, and etoposide) for HER2-negative breast cancer with brain met…
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CLINICAL_TRIALS trial_result · 2024-12-09Clinical Trial Update: Study on Prevalence and Impact of Brain Metastases on Survival in Lung Cancer by Line of Treatment
This completed clinical trial update examines how prevalent brain metastases are in lung cancer and assesses their impact on survival across…
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CLINICAL_TRIALS research · 2024-12-09Clinical Trial Update: A Retrospective Study of Prognostic Factors and Survival of Breast Cancer Patients With Brain Metastesis
This retrospective study analyzes prognostic factors and survival in patients with breast cancer who have brain metastases.
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CLINICAL_TRIALS trial_result · 2024-12-06Clinical Trial Update: Safety Study of Pritumumab in Brain Cancer [Phase 1]
Phase 1 safety study of Pritumumab in adult brain cancer patients with malignant primary brain tumors and brain metastases has completed.
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CLINICAL_TRIALS research · 2024-12-04Clinical Trial Update: Tumor Treating Fields (TTF) in Combination with Stereotactic Radiosurgery(SRS) for Brain Metastases from Non-small Cell Lung Cancer. [NA]
The document reports a clinical trial evaluating tumor treating fields in combination with stereotactic radiosurgery for brain metastases fr…
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CLINICAL_TRIALS research · 2024-11-25Clinical Trial Update: Cadonilimab Combined With Stereotactic Radiotherapy as Second-line Treatment for Brain Metastases [Phase 2]
Phase 2 clinical trial evaluating cadonilimab in combination with stereotactic radiotherapy as a second-line treatment for brain metastases …
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CLINICAL_TRIALS trial_result · 2024-11-13Clinical Trial Update: Study to Evaluate the Safety and Efficacy of Serplulimab Plus Bevacizumab and Chemotherapy in NSCLC Patients With Brain Metastases [Phase 2, Phase 3]
Phase 2/3 study evaluating the safety and efficacy of serplulimab plus bevacizumab and chemotherapy in non-small cell lung cancer patients w…
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CLINICAL_TRIALS research · 2024-11-12Clinical Trial Update: A Multicenter, Single-arm, Open-label Study Evaluating the Safety and Efficacy of AK112 Combined With Chemotherapy as First-line Treatment for Non-squamous NSCLC Patients With BRAIN Metastases and Negative Driver Genes (IVO BRAIN) [Phase 2]
A multicenter, single-arm Phase 2 trial evaluating AK112 in combination with chemotherapy as first-line treatment for patients with non-squa…
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CLINICAL_TRIALS research · 2024-11-12Clinical Trial Update: AI-guided Prognostication and Cranial Radiotherapy Optimization in EGFR-TKI-treated Non-small Cell Lung Cancer Patients With Baseline Brain Metastases
An ongoing study from Fudan University evaluating AI-guided prognostication and cranial radiotherapy optimization in EGFR-TKI–treated patien…
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CLINICAL_TRIALS trial_result · 2024-11-06Clinical Trial Update: ARRY-380 + Trastuzuamab for Breast w/ Brain Mets [Phase 1]
Phase 1 trial evaluating ARRY-380 in combination with trastuzumab for brain metastases in HER2-positive breast cancer. The study status is c…
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CLINICAL_TRIALS research · 2024-11-05Clinical Trial Update: TIL Therapy Combined With Pembrolizumab for Advanced Brain Cancer Including Gliomas and Meningiomas [Phase 1, Phase 2]
A Phase 1/2 clinical trial is evaluating the combination of tumor-infiltrating lymphocyte (TIL) therapy with pembrolizumab for advanced brai…
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CLINICAL_TRIALS research · 2024-10-31Clinical Trial Update: Study of Osimertinib + SRS vs Osimertinib Alone for Brain Metastases in EGFR Positive Patients With NSCLC [Phase 2]
A Phase 2 study is evaluating osimertinib plus stereotactic radiosurgery (SRS) versus osimertinib alone in patients with EGFR-positive non-s…