Brain Metastases
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CLINICAL_TRIALS research · 2025-05-04Clinical Trial Update: Neoadjuvant Stereotactic Radiotherapy for Brain Metastasis [NA]
This entry notes a planned clinical trial investigating neoadjuvant stereotactic radiotherapy for brain metastases, currently recruiting.
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CLINICAL_TRIALS trial_result · 2025-05-02Clinical Trial Update: Combination of Sorafenib and Radiation for Brain Metastases and Primary Brain Tumors [Phase 1]
A completed Phase 1 trial evaluating the safety and tolerability of combining sorafenib with radiation therapy in patients with brain metast…
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CLINICAL_TRIALS trial_result · 2025-05-02Clinical Trial Update: Neurosurgical Transitional Care Programme [NA]
The study NCT03593330 evaluating a Neurosurgical Transitional Care Programme at Barts & The London NHS Trust has been terminated.
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CLINICAL_TRIALS research · 2025-05-01Clinical Trial Update: ExAblate (Magnetic Resonance-guided Focused Ultrasound Surgery) Treatment of Brain Tumors [NA]
Clinical trial update on ExAblate MR-guided focused ultrasound for brain tumors, noting the study is active but not recruiting.
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CLINICAL_TRIALS research · 2025-04-25Clinical Trial Update: Optimizing Neurocognition With Whole Brain Radiation Therapy (WBRT) Using Upfront Pulsed Reduced Dose-Rate (PRDR) Technique [Phase 2]
A Phase 2 clinical trial is recruiting to optimize neurocognition in patients with brain metastases using upfront pulsed reduced dose-rate w…
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CLINICAL_TRIALS research · 2025-04-25Clinical Trial Update: UTD1 Combined With Capecitabine in Metastatic HER2-negative Breast Cancer Patients With Brain Metastases [Phase 1, Phase 2]
This clinical trial update reports a Phase 1/2 study of UTD1 in combination with Capecitabine for metastatic HER2-negative breast cancer wit…
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CLINICAL_TRIALS research · 2025-04-24Clinical Trial Update: Preoperative vs Postoperative Hypofractionated Radiosurgery for Patients With Large Brain Metastases [NA]
This clinical trial is recruiting to compare preoperative and postoperative hypofractionated radiosurgery for patients with large brain meta…
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CLINICAL_TRIALS research · 2025-04-24Clinical Trial Update: Testing Sacituzumab Govitecan Therapy in Patients With HER2-Negative Breast Cancer and Brain Metastases [Phase 2]
A Phase 2 clinical trial is evaluating sacituzumab govitecan in patients with HER2-negative metastatic breast cancer and brain metastases; t…
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CLINICAL_TRIALS research · 2025-04-24Clinical Trial Update: Prospective Double Arm Randomized Trial: WBRT Alone and WBRT Plus Silibinin [NA]
A prospective double-arm randomized trial compares whole-brain radiotherapy alone versus WBRT plus silibinin in adults with brain metastases…
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CLINICAL_TRIALS trial_result · 2025-04-23Clinical Trial Update: Evaluation of the Efficacy and Safety of Nal-IRI for Progressing Brain Metastases in Breast Cancer Patients [Phase 2]
This document reports the completion of a Phase 2 trial evaluating liposomal irinotecan (Nal-IRI) for brain metastases in breast cancer pati…
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CLINICAL_TRIALS research · 2025-04-18Clinical Trial Update: Hippocampus-Avoidance Whole-Brain Radiation Therapy With Simultaneous Integrated Boost for BMs of NSCLC [NA]
Clinical trial update on hippocampus-avoidance whole-brain radiation therapy with simultaneous integrated boost for brain metastases from no…
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CLINICAL_TRIALS trial_result · 2025-04-17Clinical Trial Update: RAPid SimPLE Targeted Radiation Treatment for Brain Metastases [Phase 2]
Phase 2 clinical trial update for RAPid SimPLE Targeted Radiation Treatment in brain metastases; the study is currently recruiting.
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CLINICAL_TRIALS trial_result · 2025-04-09Clinical Trial Update: Managing Distress in Malignant Brain Cancer [NA]
The document reports completion and posted results for a clinical trial focused on distress management in adults with brain metastases.
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CLINICAL_TRIALS trial_result · 2025-04-09Clinical Trial Update: Nivolumab and Ipilimumab Plus Chemotherapy for Patients With Stage IV Lung Cancer With Brain Metastases [Phase 2]
A Phase 2 trial of nivolumab and ipilimumab with chemotherapy for stage IV non-small cell lung cancer with brain metastases is currently act…
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CLINICAL_TRIALS research · 2025-03-21Clinical Trial Update: Radiosurgery Before Surgery for the Treatment of Brain Metastases [EARLY_Phase 1]
This document reports an early-phase clinical trial evaluating radiosurgery before surgery for brain metastases, with the study currently ac…
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CLINICAL_TRIALS trial_result · 2025-03-20Clinical Trial Update: Phase 2 Trial in Multiple Brain Metastases Outcomes With HA-SIB-WBRT [Phase 2]
Phase 2 trial evaluating hippocampus-avoidance simultaneous integrated boost whole-brain radiotherapy for patients with multiple brain metas…
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CLINICAL_TRIALS trial_result · 2025-03-11Clinical Trial Update: Multicenter Retrospective Study on Patients Treated with Stereotactic Radiosurgery/Radiotherapy for Single Brain Lesions: Evaluation of Treatment Efficacy and Safety, Also Through Radiomic Analysis Methods.
A multicenter retrospective study evaluating the efficacy and safety of stereotactic radiosurgery/radiotherapy for a single brain lesion, wi…
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CLINICAL_TRIALS trial_result · 2025-03-05Clinical Trial Update: A Phase II Study of Pre-Op SRS Followed by Surgical Resection for Brain Metastases [NA]
Phase II study evaluating pre-operative stereotactic radiosurgery followed by surgical resection for brain metastases. The study is currentl…
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CLINICAL_TRIALS research · 2025-02-28Clinical Trial Update: Efficacy of the RayerKnife X Stereotactic Radiotherapy System in the Treatment of Brain Metastases [NA]
A clinical trial is planned to evaluate the RayerKnife X Stereotactic Radiotherapy System for treating brain metastases, with recruitment no…
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CLINICAL_TRIALS research · 2025-02-27Clinical Trial Update: A Study Comparing GLIADEL to Stereotactic Radiosurgery in Metastatic Brain Disease [Phase 2]
A Phase 2 clinical trial is evaluating GLIADEL wafers versus stereotactic radiosurgery for metastatic brain tumors and is currently recruiti…
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CLINICAL_TRIALS research · 2025-02-21Clinical Trial Update: Evaluating the Efficacy and Safety of PD-L1 Monoclonal Antibody Combined with VEX Metronomic Chemotherapy and Concurrent or Delayed Radiotherapy in Patients with Advanced HER2-Negative Breast Cancer with Brain Metastasis [Phase 2]
Phase 2 clinical trial evaluating a PD-L1 monoclonal antibody with VEX metronomic chemotherapy and concurrent or delayed radiotherapy for ad…
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CLINICAL_TRIALS trial_result · 2025-02-13Clinical Trial Update: A Trial Evaluating Concurrent Whole Brain Radiotherapy and Iniparib in Multiple Non Operable Brain Metastases [Phase 1]
A Phase 1 trial evaluating concurrent whole-brain radiotherapy and Iniparib in patients with multiple non-operable brain metastases has been…
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CLINICAL_TRIALS research · 2025-02-11Clinical Trial Update: Stereotactic Radiotherapy for Cerebral Metastases with Recent Hemorrhagic Signal [Phase 2]
Phase 2 clinical trial evaluating stereotactic radiotherapy for hemorrhagic brain metastases is currently recruiting, sponsored by Centre Fr…
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CLINICAL_TRIALS research · 2025-02-06Clinical Trial Update: Study of SHR-A1811 Combined With Pyrotinib and Bevacizumab in Advanced Breast Cancer With Brain Metastasis [Phase 1, Phase 2]
A Phase 1/2 clinical trial is evaluating SHR-A1811 with Pyrotinib and Bevacizumab for advanced breast cancer with brain metastases. The stud…
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CLINICAL_TRIALS trial_result · 2025-02-03Clinical Trial Update: Study of Osimertinib in Patients with a Lung Cancer with Brain or Leptomeningeal Metastases with EGFR Mutation [Phase 2]
Phase 2 trial evaluating Osimertinib in EGFR-mutant non-small cell lung cancer with brain or leptomeningeal metastases has completed. The st…