Amyotrophic Lateral Sclerosis
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CLINICAL_TRIALS withdrawal · 2025-09-02Clinical Trial Update: Intermediate-Sized Expanded Access Study
An intermediate-sized expanded access study for amyotrophic lateral sclerosis sponsored by Seelos Therapeutics is no longer available.
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CLINICAL_TRIALS trial_result · 2025-08-29Clinical Trial Update: Long-Term Evaluation of BIIB067 (Tofersen) [Phase 3]
Long-term evaluation results for tofersen (BIIB067) in amyotrophic lateral sclerosis due to SOD1 mutation have been posted from a Phase 3 tr…
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CLINICAL_TRIALS trial_result · 2025-08-29Clinical Trial Update: A Study Evaluating the Safety and Tolerability of QRL-201 in ALS [Phase 1]
This Phase 1 trial assesses the safety and tolerability of QRL-201 in amyotrophic lateral sclerosis. It is currently active but not recruiti…
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CLINICAL_TRIALS research · 2025-08-28Clinical Trial Update: An IIT Clinical Study to Evaluate the Safety and Efficacy of a Single Intrathecal Injection of RJK002 in Patients With ALS [EARLY_Phase 1]
The document describes an investigator-initiated Phase 1 study to assess the safety and efficacy of a single intrathecal injection of RJK002…
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CLINICAL_TRIALS research · 2025-08-28Clinical Trial Update: Effects of Long Term Ventilation Support on the Quality of Life of ALS Patients and Their Families [NA]
This clinical trial evaluates the impact of long-term ventilation support on quality of life for people with amyotrophic lateral sclerosis a…
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CLINICAL_TRIALS research · 2025-08-28Clinical Trial Update: Amyotrophic Lateral Sclerosis: A Multicenter Retrospective Observational Registry
This entry describes a multicenter retrospective observational registry for amyotrophic lateral sclerosis that is currently active but not r…
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CLINICAL_TRIALS research · 2025-08-24Clinical Trial Update: Mitochondrial Capacity Boost in ALS (MICABO-ALS) Trial [Phase 2]
The MICABO-ALS trial is a Phase 2 study aimed at boosting mitochondrial capacity in amyotrophic lateral sclerosis and is currently recruitin…
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CLINICAL_TRIALS trial_result · 2025-08-22Clinical Trial Update: Patients With ALS and Other Motor Disorders Will be Treated With Mesenchymal Cell Exosome Solution [Phase 1]
This clinical trial update reports the completion of a Phase 1 study evaluating a Mesenchymal Cell Exosome Solution in patients with amyotro…
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CLINICAL_TRIALS other · 2025-08-22Clinical Trial Update: FHND1002 for ALS Treatment: Phase 2 [Phase 2]
Phase 2 clinical trial update for FHND1002 in amyotrophic lateral sclerosis, with recruitment not yet started.
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CLINICAL_TRIALS trial_result · 2025-08-20Clinical Trial Update: Study of AMDX-2011P as a Retinal Tracer in Subjects With Neurodegenerative Diseases Associated With Amyloidogenic Proteinopathy [Phase 1, Phase 2]
Phase 1/2 study of AMDX-2011P as a retinal tracer in Parkinson's disease and Amyotrophic Lateral Sclerosis has completed enrollment. Results…
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CLINICAL_TRIALS trial_result · 2025-08-20Clinical Trial Update: Dose-Escalation, Safety and Pharmacokinetic Study of IC14 in Motor Neurone Disease [Phase 1]
Phase 1 dose-escalation study evaluating safety, tolerability and pharmacokinetics of IC14 in motor neuron disease/ALS; the trial has comple…
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CLINICAL_TRIALS withdrawal · 2025-08-20Clinical Trial Update: IC14 for ALS Patients Expanded Access
The Expanded Access program for IC14 in Amyotrophic Lateral Sclerosis has ended and is no longer available.
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CLINICAL_TRIALS trial_result · 2025-08-19Clinical Trial Update: A Study to Evaluate, Safety, Tolerability, Pharmacodynamic (PD) Markers and Pharmacokinetics (PK) of AP-101 in Participants With Amyotrophic Lateral Sclerosis (ALS) [Phase 2]
The update notes the completion of a Phase 2 study evaluating AP-101 in amyotrophic lateral sclerosis, assessing safety, tolerability, pharm…
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CLINICAL_TRIALS research · 2025-08-19Clinical Trial Update: CNS10-NPC-GDNF Delivered to the Motor Cortex for ALS [Phase 1]
Phase 1 clinical trial update for CNS10-NPC-GDNF delivered to the motor cortex in amyotrophic lateral sclerosis.
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CLINICAL_TRIALS research · 2025-08-19Clinical Trial Update: Studies in Amyotrophic Lateral Sclerosis (ALS) and Other Neurodegenerative Motor Neuron Disorders
ClinicalTrials.gov entry indicates Mayo Clinic–sponsored studies are actively recruiting for trials addressing amyotrophic lateral sclerosis…
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CLINICAL_TRIALS research · 2025-08-19Clinical Trial Update: Oral Intake of Enteral Nutrition Formula Preceding Placement and Feeding Via GTube and Its Impact on Formula Intolerance in pALS [NA]
A clinical trial evaluating whether pre-feeding with an enteral nutrition formula before G-tube placement reduces formula intolerance in ind…
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CLINICAL_TRIALS research · 2025-08-17Clinical Trial Update: GB-PRIME: An Early Feasibility Study of a Precise Robotically Implanted Brain-Computer Interface for the Control of External Devices [NA]
An early-feasibility study of a robotically implanted brain-computer interface (GB-PRIME) by Neuralink for controlling external devices. Rec…
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CLINICAL_TRIALS withdrawal · 2025-08-17Clinical Trial Update: IC14 for Treatment of Amyotrophic Lateral Sclerosis [Phase 2]
A Phase 2 clinical trial of IC14 for amyotrophic lateral sclerosis has been withdrawn.
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CLINICAL_TRIALS research · 2025-08-14Clinical Trial Update: Human Amniotic Mesenchymal Cell Secretome for Neurodegeneration and Neuroinflammation [NA]
A clinical trial evaluating the use of human amniotic mesenchymal cell secretome for neurodegeneration and neuroinflammation, with recruitme…
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CLINICAL_TRIALS trial_result · 2025-08-13Clinical Trial Update: Open Label Extension Study of AMX0035 in Patients With ALS [Phase 2]
An open-label extension study of AMX0035 in Amyotrophic Lateral Sclerosis (ALS) completed Phase 2, with results from the extension reported.
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CLINICAL_TRIALS research · 2025-08-08Clinical Trial Update: AIM's Writing for Healing: A Workshop for Individuals Living With Paralysis
This clinical trial update describes AIM's Writing for Healing workshop for people living with paralysis, sponsored by the University of Ala…
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CLINICAL_TRIALS trial_result · 2025-08-08Clinical Trial Update: Yogic Breathing Exercise for People With Amyotrophic Lateral Sclerosis [NA]
A clinical trial evaluating a yogic breathing exercise for people with amyotrophic lateral sclerosis (and myasthenia gravis) has completed.
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CLINICAL_TRIALS trial_result · 2025-08-07Clinical Trial Update: Remotely Supervised tDCS for Slowing ALS Disease Progression [NA]
A completed clinical trial evaluated remotely supervised transcranial direct current stimulation (tDCS) to slow progression in amyotrophic l…
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CLINICAL_TRIALS research · 2025-08-05Clinical Trial Update: Personalized Antisense Oligonucleotide Therapy for A Single Participant With CHCHD10 ALS [Phase 1, Phase 2]
A single-participant Phase 1/2 trial is evaluating a personalized antisense oligonucleotide therapy for CHCHD10-related amyotrophic lateral …
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CLINICAL_TRIALS trial_result · 2025-08-01Clinical Trial Update: Study to Assess the Effects of PTC857 Treatment in Participants With Amyotrophic Lateral Sclerosis ALS [Phase 2]
A Phase 2 study of PTC857 in amyotrophic lateral sclerosis was terminated, with results posted.