Amyotrophic Lateral Sclerosis
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CLINICAL_TRIALS trial_result · 2025-08-01Clinical Trial Update: A Phase 1 Study to Investigate the Safety and Pharmacokinetics of Fosigotifator in Patients With Amyotrophic Lateral Sclerosis [Phase 1]
A Phase 1 study evaluating the safety and pharmacokinetics of Fosigotifator in patients with Amyotrophic Lateral Sclerosis has been terminat…
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CLINICAL_TRIALS research · 2025-08-01Clinical Trial Update: Generation of Cell Banks and Biomarker Isolation From Patients With Amyotrophic Lateral Sclerosis (ALS) (HCD-SLA)
This document is a clinical trial update for NCT07099066 outlining the generation of cell banks and isolation of biomarkers from ALS patient…
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CLINICAL_TRIALS research · 2025-07-31Clinical Trial Update: Personalized Antisense Oligonucleotide for Participants With CHCHD10 ALS [Phase 1, Phase 2]
A Phase 1/2 clinical trial is evaluating a personalized antisense oligonucleotide targeting CHCHD10 in amyotrophic lateral sclerosis, with e…
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CLINICAL_TRIALS research · 2025-07-30Clinical Trial Update: Safety of Intrathecal Riluzole in Patients With Amyotrophic Lateral Sclerosis [Phase 1]
Phase 1 clinical trial evaluating the safety of intrathecal riluzole in people with amyotrophic lateral sclerosis; the study is not yet recr…
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CLINICAL_TRIALS research · 2025-07-25Clinical Trial Update: Investigation on the Cortical Communication (CortiCom) System [NA]
Ongoing recruitment for the CortiCom cortical communication system trial sponsored by Johns Hopkins University, evaluating its use in tetrap…
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CLINICAL_TRIALS research · 2025-07-25Clinical Trial Update: Personalized Antisense Oligonucleotide for a Single Participant With CHCHD10 ALS [Phase 1, Phase 2]
Clinical trial update on a personalized antisense oligonucleotide for CHCHD10-related amyotrophic lateral sclerosis, covering Phase 1/Phase …
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CLINICAL_TRIALS research · 2025-07-24Clinical Trial Update: A Study to Evaluate the Efficacy and Safety of Different Doses of CB03-154 in Adult Patients With Amyotrophic Lateral Sclerosis (ALS) [Phase 2, Phase 3]
A Phase 2/3 clinical trial to evaluate the efficacy and safety of different doses of CB03-154 in adults with Amyotrophic Lateral Sclerosis; …
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CLINICAL_TRIALS research · 2025-07-23Clinical Trial Update: Study on the Safety and Efficacy of RAG-21 in the Treatment of Amyotrophic Lateral Sclerosis Patients With FUS Gene Mutations [EARLY_Phase 1]
An early-phase 1 clinical trial update reports evaluating the safety and potential efficacy of RAG-21 for amyotrophic lateral sclerosis in p…
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CLINICAL_TRIALS research · 2025-07-22Clinical Trial Update: Extended Study of RAG-17 in the Treatment of Amyotrophic Lateral Sclerosis Patients With SOD1 Gene Mutation [EARLY_Phase 1]
This is an early-phase update describing an extended study of RAG-17 for amyotrophic lateral sclerosis patients with the SOD1 gene mutation.…
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CLINICAL_TRIALS research · 2025-07-20Clinical Trial Update: Using the EHR to Advance Genomic Medicine Across a Diverse Health System [NA]
This update describes a University of Pennsylvania-led trial that uses electronic health records to advance genomic medicine across a divers…
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CLINICAL_TRIALS trial_result · 2025-07-11Clinical Trial Update: Triumeq in Amyotrophic Lateral Sclerosis [Phase 3]
A Phase 3 trial of Triumeq for amyotrophic lateral sclerosis has been terminated.
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CLINICAL_TRIALS research · 2025-07-11Clinical Trial Update: ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)
This is a clinical trial registry update for the ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) study. Recruitment is…
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CLINICAL_TRIALS research · 2025-07-09Clinical Trial Update: Multicenter ALS Imaging Study
This clinical trial update describes a multicenter ALS imaging study sponsored by the University of Minnesota that is currently recruiting p…
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CLINICAL_TRIALS research · 2025-07-08Clinical Trial Update: hUC-MSC-sEV-001 Nasal Drops for Neurodegenerative Diseases [Phase 1]
Phase 1 trial update for hUC-MSC-sEV-001 nasal drops across several neurodegenerative diseases; the study is not yet recruiting.
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CLINICAL_TRIALS research · 2025-07-08Clinical Trial Update: Digital Assessment of Speech and Fine Motor Control in ALS
This ClinicalTrials.gov listing describes a study evaluating digital assessment of speech and fine motor function in people with amyotrophic…
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CLINICAL_TRIALS research · 2025-07-03Clinical Trial Update: Phenotype, Genotype & Biomarkers in ALS and Related Disorders
An ongoing University of Miami-led clinical trial investigating phenotype, genotype, and biomarkers in amyotrophic lateral sclerosis and rel…
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CLINICAL_TRIALS research · 2025-07-03Clinical Trial Update: Metagenomic Characterization of the Intestinal Microbiota in ALS Patients and Association With Clinical Phenotypes
This clinical trial aims to characterize the metagenomic composition of the intestinal microbiota in patients with amyotrophic lateral scler…
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CLINICAL_TRIALS research · 2025-07-02Clinical Trial Update: HD-tDCS in Amyotrophic Lateral Sclerosis: A Multicenter Randomized Controlled Trial [Phase 2, Phase 3]
This item reports a multicenter randomized trial investigating high-definition transcranial direct current stimulation (HD-tDCS) for amyotro…
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CLINICAL_TRIALS trial_result · 2025-07-01Clinical Trial Update: RT001 in Amyotrophic Lateral Sclerosis [Phase 2]
The Phase 2 clinical trial of RT001 for amyotrophic lateral sclerosis has completed. The study is sponsored by Biojiva LLC.
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CLINICAL_TRIALS trial_result · 2025-06-29Clinical Trial Update: Study of SPG302 in Healthy Volunteers and ALS Participants [Phase 1]
Phase 1 trial of SPG302 in healthy volunteers and ALS participants has completed.
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CLINICAL_TRIALS trial_result · 2025-06-26Clinical Trial Update: A Safety and Tolerability Study of ILB® in Patients With Amyotrophic Lateral Sclerosis (ALS) [Phase 2]
Phase 2 safety and tolerability study of ILB in patients with amyotrophic lateral sclerosis has been terminated; results have been posted.
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CLINICAL_TRIALS trial_result · 2025-06-22Clinical Trial Update: Study of Safety, Tolerability, and Biological Activity of LAM-002A in C9ORF72-Associated Amyotrophic Lateral Sclerosis [Phase 2]
Phase 2 study evaluating LAM-002A in C9orf72-associated amyotrophic lateral sclerosis has completed, assessing safety, tolerability, and bio…
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CLINICAL_TRIALS trial_result · 2025-06-18Clinical Trial Update: A Phase 2 Study to Evaluate AL001 in C9orf72-Associated ALS [Phase 2]
A Phase 2 trial evaluating AL001 in C9orf72-associated amyotrophic lateral sclerosis has been terminated, with results posted.
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CLINICAL_TRIALS research · 2025-06-18Clinical Trial Update: RAPA-501 Therapy for ALS [Phase 2, Phase 3]
A Phase 2/3 clinical trial investigating RAPA-501 therapy for amyotrophic lateral sclerosis is currently recruiting.
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CLINICAL_TRIALS trial_result · 2025-06-15Clinical Trial Update: Safety and Gut Microbiota Analysis of an Oral Microbiotherapy in Patients With Amyotrophic Lateral Sclerosis [Phase 1]
Phase 1 trial evaluating the safety and gut microbiota effects of an oral microbiotherapy in patients with amyotrophic lateral sclerosis has…