Amyotrophic Lateral Sclerosis
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease [Phase 1]
A Phase 1 clinical trial is evaluating PET imaging of cyclooxygenases in neurodegenerative brain diseases, with recruitment ongoing.
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: HEALEY ALS Platform Trial - Master Protocol [Phase 2, Phase 3]
HEALEY ALS Platform Trial master protocol for Phase 2 and Phase 3 arms in amyotrophic lateral sclerosis. Recruitment is ongoing.
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
An ongoing National Institute of Neurological Disorders and Stroke study investigates complex neurodegenerative disorders related to amyotro…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Pridopidine Phase 3 Study to Evaluate Efficacy and Safety in ALS [Phase 3]
The Phase 3 trial of pridopidine for amyotrophic lateral sclerosis is currently recruiting, with the study designed to evaluate its efficacy…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: Acamprosate in C9orf72 Hexanucleotide Repeat Expansion Amyotrophic Lateral Sclerosis (ACALS) [Phase 1]
Phase 1 clinical trial update on acamprosate for ALS with C9orf72 hexanucleotide repeat expansion (ACALS). The study is currently active but…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: EIM Via the Myolex mScan as an ALS Biomarker
An ALS biomarker study is evaluating the Myolex mScan in a clinical trial sponsored by Beth Israel Deaconess Medical Center. The study is cu…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: A Study to Investigate the Safety and Pharmacodynamics of a Single Intrathecal Injection (IT) of INS1202 in Participants With Amyotrophic Lateral Sclerosis (ALS) [Phase 1]
Phase 1 study to evaluate the safety and pharmacodynamics of a single intrathecal injection of INS1202 in participants with amyotrophic late…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Invasive Home Ventilation in Denmark
A Danish clinical trial sponsored by Rigshospitalet is studying invasive home ventilation for patients with neuromuscular diseases, includin…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Study of COYA 302 for the Treatment of ALS [Phase 2]
A Phase 2 clinical trial evaluating COYA 302 for amyotrophic lateral sclerosis is currently recruiting.
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: A Clinical Trial of Early Ventilation in Amyotrophic Lateral Sclerosis (EVENT ALS) [Phase 2]
A Phase 2 clinical trial (EVENT ALS) evaluating early ventilation in patients with amyotrophic lateral sclerosis and chronic respiratory fai…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: Longitudinal Assessment of Autonomic and Sensory Nervous System in ALS [NA]
The study 'Longitudinal Assessment of Autonomic and Sensory Nervous System in ALS' is currently recruiting to evaluate autonomic and sensory…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Functional Outcomes and Control Using Synchron BCI - Australia [NA]
Clinical trial update for Synchron's brain-computer interface device in Australia; the study targets neurologic disorders and is currently n…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: AMX0114 in Adult Participants With Amyotrophic Lateral Sclerosis [Phase 1]
A Phase 1 clinical trial update shows AMX0114 is recruiting in adults with amyotrophic lateral sclerosis.
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: Connect-One: Early Feasibility Study of Connexus® Brain-Computer Interface (BCI) [NA]
Early feasibility study update for the Connexus Brain-Computer Interface by Paradromics; the trial is currently recruiting for ALS, neuromus…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: Natural History and Biomarkers of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Caused by the C9ORF72 Gene Mutation
A completed NINDS study examining the natural history and biomarkers of amyotrophic lateral sclerosis and frontotemporal lobar degeneration …
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Intestinal Microbiome Transplant in ALS [Phase 1, Phase 2]
A Duke University-sponsored Phase 1/2 clinical trial is evaluating an intestinal microbiome transplant for amyotrophic lateral sclerosis (AL…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Study of [11C]CPPC as a Clinical PET Radioligand Biomarker of Microglial Activation in ALS [Phase 1, Phase 2]
A clinical trial registry update describing a Phase 1/Phase 2 study of the PET radioligand [11C]CPPC as a biomarker of microglial activation…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Modeling Amyotrophic Lateral Sclerosis With Fibroblasts [NA]
A clinical trial update describes modeling amyotrophic lateral sclerosis using patient-derived fibroblasts; the study is currently recruitin…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Interfacing With NeuroTechnology to Expand Neural Throughput (INTENT) [NA]
Johns Hopkins University reports a clinical trial investigating interfacing with neurotechnology to expand neural throughput for individuals…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Comprehensive Analysis Platform To Understand, Remedy and Eliminate ALS
A University of Alberta-led clinical trial aims to build a comprehensive analysis platform to understand, remedy, and potentially eliminate …
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Study is to Assess the Safety and Tolerability of VTx-002 in Participants With ALS [Phase 1, Phase 2]
A Phase 1/2 clinical trial is planned to evaluate the safety and tolerability of VTx-002 in participants with amyotrophic lateral sclerosis,…
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CLINICAL_TRIALS research · 2026-04-09Clinical Trial Update: A Study to Learn More About the Long-Term Safety of Tofersen (Qalsody) in Participants With Superoxide Dismutase 1 (SOD-1) Amyotrophic Lateral Sclerosis (ALS)
A study to learn more about the long-term safety of Tofersen (Qalsody) in participants with SOD1-associated amyotrophic lateral sclerosis is…
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: A Safety and Efficacy Study of ARGX-119 in Adult Patients With Amyotrophic Lateral Sclerosis (ALS) [Phase 2]
Clinical trial update for ARGX-119 in adults with amyotrophic lateral sclerosis (ALS), a Phase 2 safety and efficacy study currently active …
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CLINICAL_TRIALS research · 2026-04-07Clinical Trial Update: Intermediate Expanded Access Protocol CNMAu8.EAP04
This update notes that the intermediate expanded access protocol CNMAu8.EAP04 for Amyotrophic Lateral Sclerosis is temporarily not available…
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CLINICAL_TRIALS research · 2026-04-07Clinical Trial Update: Mechanical Insufflation in the Philadelphia Amyotrophic Lateral Sclerosis Cohort (MI-PALS) Study [NA]
This document provides an update on the MI-PALS trial investigating mechanical insufflation in a Philadelphia ALS cohort; the study status i…