Amyotrophic Lateral Sclerosis
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-10-07Clinical Trial Update: Augmented Reality BCI Longitudinal Study for Persons With ALS, Stroke, TBI and SCI Utilizing Cognixion + Apple Vision Pro [NA]
Update on a longitudinal study evaluating an augmented reality brain-computer interface using Cognixion and Apple Vision Pro for people with…
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CLINICAL_TRIALS other · 2025-10-03Clinical Trial Update: Efficacy and Safety of Masitinib in Combination With SoC Versus Placebo in the Treatment of ALS Patients [Phase 3]
Phase 3 trial update evaluating masitinib in combination with standard of care versus placebo for amyotrophic lateral sclerosis; the study i…
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CLINICAL_TRIALS research · 2025-10-01Clinical Trial Update: Integrating Metabolism, Connectivity, and Mesoscale Imaging at Ultra-high Field to Decipher Mechanisms of Resilience and Neurodegeneration in Neurological Diseases and Healthy Aging
An ongoing sponsor-initiated study is evaluating metabolism, connectivity, and ultra-high-field mesoscopic imaging to uncover mechanisms of …
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CLINICAL_TRIALS trial_result · 2025-09-29Clinical Trial Update: Individual Patient Expanded Access IND of Autologous HBadMSCs for the Treatment of Amyotrophic Lateral Sclerosis
Update on an individual patient expanded access IND using autologous HBadMSCs to treat amyotrophic lateral sclerosis. The status shows the t…
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CLINICAL_TRIALS trial_result · 2025-09-26Clinical Trial Update: ROAR-DIGAP: A Widely Inclusive, Largely Virtual Pilot Trial Utilizing DIGAP (Deep Integrated Genomics Analysis Platform) To Personalize Treatments [Phase 2]
Phase 2 clinical trial update for ROAR-DIGAP, a Duke University pilot study using the Deep Integrated Genomics Analysis Platform to personal…
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CLINICAL_TRIALS research · 2025-09-26Clinical Trial Update: Intravenous Immunoglobulin (IVIG) and Blood-Brain Barrier Disruption in Amyotrophic Lateral Sclerosis (ALS) [Phase 1]
This entry notes a Phase 1 clinical trial evaluating intravenous immunoglobulin with blood-brain barrier disruption for amyotrophic lateral …
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CLINICAL_TRIALS research · 2025-09-25Clinical Trial Update: Clinical Study of Regulatory T Cells (Tregs) in the Treatment of Neurodegenerative Diseases [Phase 1]
A Phase 1 clinical trial evaluating regulatory T cell therapy for amyotrophic lateral sclerosis is currently recruiting, sponsored by Novabi…
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CLINICAL_TRIALS trial_result · 2025-09-25Clinical Trial Update: Trial on the Biological and Clinical Effects of Acetyl-L-carnitine in ALS [Phase 2, Phase 3]
An ongoing Phase 2/Phase 3 trial is evaluating the biological and clinical effects of Acetyl-L-carnitine in amyotrophic lateral sclerosis an…
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CLINICAL_TRIALS research · 2025-09-25Clinical Trial Update: Non-invasive Brain Stimulation and Exercise Intervention for Patients With Motor Neuron Disease [NA]
This clinical trial entry describes a study evaluating non-invasive brain stimulation in combination with exercise for patients with Amyotro…
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CLINICAL_TRIALS trial_result · 2025-09-22Clinical Trial Update: Study to Evaluate DNL747 in Subjects With Amyotrophic Lateral Sclerosis [Phase 1]
A Phase 1 study evaluating the investigational drug DNL747 for amyotrophic lateral sclerosis has been terminated.
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CLINICAL_TRIALS research · 2025-09-22Clinical Trial Update: Analysis of Human ALS Tissues and Registry of ALS Patients
A clinical trial update for NCT05067179 investigating analysis of human ALS tissues and a registry of ALS patients, currently recruiting.
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CLINICAL_TRIALS trial_result · 2025-09-19Clinical Trial Update: Polish Version Dyspnea in Amyotrophic Lateral Sclerosis
An update indicates that the Polish version of a clinical trial investigating dyspnea in amyotrophic lateral sclerosis is not yet recruiting…
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CLINICAL_TRIALS trial_result · 2025-09-17Clinical Trial Update: Longitudinal Evaluation of Short-Chain Fatty Acid Profiles During the Natural Disease Course and a Mediterranean Diet Intervention in Amyotrophic Lateral Sclerosis Patients
Clinical trial update announcing completion of a study examining longitudinal short-chain fatty acid profiles in the natural course of amyot…
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CLINICAL_TRIALS research · 2025-09-16Clinical Trial Update: Amyotrophic Lateral Sclerosis Registry in Thailand
A clinical trial registry entry for an ALS registry in Thailand, sponsored by Chulalongkorn University. The study is currently recruiting.
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CLINICAL_TRIALS research · 2025-09-15Clinical Trial Update: Safety and Efficacy of Intravenous Administration of SHED-CM for ALS [EARLY_Phase 1]
An early-phase clinical trial evaluates the safety and potential efficacy of intravenous SHED-CM for amyotrophic lateral sclerosis, sponsore…
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CLINICAL_TRIALS research · 2025-09-15Clinical Trial Update: Electrophysiology and Ultrasound of Respiratory Muscles and Respective Nerves to Predict Respiratory Insufficiency in ALS
This clinical trial is evaluating electrophysiology and ultrasound of respiratory muscles and nerves to predict respiratory insufficiency in…
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CLINICAL_TRIALS research · 2025-09-12Clinical Trial Update: Efficacy and Safety of Masitinib Versus Placebo in the Treatment of ALS Patients [Phase 3]
Ongoing Phase 3 trial evaluating the efficacy and safety of masitinib versus placebo in patients with amyotrophic lateral sclerosis; the stu…
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CLINICAL_TRIALS research · 2025-09-12Clinical Trial Update: Dynamic Impact of NIV on Diaphragmatic Ultrasound in Patients With Amyotrophic Lateral Sclerosis
This is a clinical trial update studying how non-invasive ventilation affects diaphragmatic ultrasound in patients with amyotrophic lateral …
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FDA approval · 2025-09-11FDA Approved: TIGLUTIK — Supplemental Application (EDW PHARMA, INC)
FDA approved a supplemental application for TIGLUTIK (riluzole) filed by EDW PHARMA, INC, resulting in approved labeling changes.
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CLINICAL_TRIALS research · 2025-09-11Clinical Trial Update: A Phase Ⅰ/Ⅱa Study of SNUG01 in Adult Subjects With ALS [Phase 1, Phase 2]
Phase 1/2a clinical trial of SNUG01 for amyotrophic lateral sclerosis is not yet recruiting.
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CLINICAL_TRIALS research · 2025-09-10Clinical Trial Update: Development and Validation of the FBIndex to Determine the Risk of Falls for Patients With Neuromuscular Disorders
Development and validation of the FBIndex, a tool to assess falls risk in patients with various neuromuscular disorders.
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CLINICAL_TRIALS trial_result · 2025-09-05Clinical Trial Update: A Phase IIb, Multi-Center, Multinational, Double-Blind, Placebo-Controlled Study, With an Open Label Extension, to Evaluate Safety, Tolerability and Efficacy of PrimeC in Subjects With ALS [Phase 2]
Phase IIb multicenter, multinational trial of PrimeC in amyotrophic lateral sclerosis has completed and evaluated safety, tolerability and e…
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CLINICAL_TRIALS research · 2025-09-05Clinical Trial Update: A Study to Assess the Safety, Tolerability, and Pharmacology of Darifenacin in Patients With ALS [Phase 2]
A Phase 2 clinical trial is evaluating the safety, tolerability, and pharmacology of darifenacin in patients with amyotrophic lateral sclero…
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CLINICAL_TRIALS other · 2025-09-03Clinical Trial Update: Obi Medical Robot: Evaluating Effectiveness Related to Usability
A clinical trial update on the Obi Medical Robot evaluating usability-related effectiveness for individuals with upper extremity impairments…
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CLINICAL_TRIALS trial_result · 2025-09-02Clinical Trial Update: A Study Exploring the PK/PD Relationship of QRL-101 in Adults With ALS [Phase 1]
This update reports the completion of a Phase 1 study evaluating the pharmacokinetic and pharmacodynamic relationship of QRL-101 in adults w…