High-grade Glioma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2015-08-24Clinical Trial Update: Irinotecan in Combination With Cisplatin in Pediatric Patients With Unfavorable Prognosis Gliomas [Phase 2]
Phase 2 trial update evaluating irinotecan in combination with cisplatin for pediatric high-grade glioma; trial status completed.
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CLINICAL_TRIALS withdrawal · 2015-08-05Clinical Trial Update: Carboplatin, Temozolomide, and Filgrastim in Treating Patients With Newly Diagnosed or Recurrent High-Grade Glioma [Phase 2]
A Phase 2 trial evaluating carboplatin, temozolomide, and filgrastim for newly diagnosed or recurrent high-grade glioma has been withdrawn.
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CLINICAL_TRIALS trial_result · 2015-07-21Clinical Trial Update: Cilengitide and Metronomic Temozolomide for Relapsed or Refractory High Grade Gliomas or Diffuse Intrinsic Pontine Gliomas in Children and Adolescents [Phase 2]
Phase 2 trial in children tested cilengitide with metronomic temozolomide for relapsed or refractory high-grade gliomas and diffuse intrinsi…
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CLINICAL_TRIALS trial_result · 2015-05-07Clinical Trial Update: High-Dose Chemotherapy Plus Autologous Stem Cell Transplantation Compared With Intermediate-Dose Chemotherapy Plus Autologous Stem Cell Transplantation With or Without Isotretinoin in Treating Young Patients With Recurrent High-Grade Gliomas [Phase 3]
A Phase 3 trial comparing high-dose chemotherapy plus autologous stem cell transplantation to intermediate-dose chemotherapy plus autologous…
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CLINICAL_TRIALS trial_result · 2015-04-30Clinical Trial Update: CC-8490 in Treating Patients With Recurrent or Refractory High-Grade Gliomas [Phase 1]
ClinicalTrials.gov reports on a Phase 1 study of CC-8490 in patients with recurrent or refractory high-grade gliomas. The trial status is co…
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CLINICAL_TRIALS trial_result · 2015-04-10Clinical Trial Update: Positron Emission Tomography-Computed Tomography (PET-CT) High-grade Glioma
The PET-CT study for high-grade glioma sponsored by Maastricht Radiation Oncology has been terminated.
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CLINICAL_TRIALS trial_result · 2014-08-08Clinical Trial Update: A Proof-of-concept Study to Assess the Ability of [18F]AH-111585 PET Imaging to Detect Tumours and Angiogenesis [Phase 2]
Phase 2 proof-of-concept study evaluating the PET imaging tracer [18F]AH-111585 for detecting tumors and angiogenesis, with results posted i…
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CLINICAL_TRIALS trial_result · 2014-06-24Clinical Trial Update: Valproic Acid With Temozolomide and Radiation Therapy to Treat Brain Tumors [Phase 2]
This update reports the completion of a Phase 2 clinical trial evaluating valproic acid in combination with temozolomide and radiation thera…
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CLINICAL_TRIALS trial_result · 2014-02-20Clinical Trial Update: Cilengitide in Treating Younger Patients With Recurrent or Progressive High-Grade Glioma That Has Not Responded to Standard Therapy [Phase 2]
This Phase 2, NCI-sponsored trial evaluated cilengitide in children and adolescents with recurrent or progressive high-grade glioma refracto…
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CLINICAL_TRIALS research · 2013-12-30Clinical Trial Update: Permeability Map to Distinguish Progression From Pseudoprogression in High-Grade Glioma
Clinical trial evaluating a permeability-mapping imaging approach to distinguish progression from pseudoprogression in high-grade glioma. Sp…
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CLINICAL_TRIALS trial_result · 2013-10-29Clinical Trial Update: Temozolomide in Treating Patients With Recurrent High-Grade Glioma [Phase 2]
Phase 2 clinical trial of temozolomide in patients with recurrent high-grade glioma has completed with results posted in 2013.
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CLINICAL_TRIALS trial_result · 2013-10-08Clinical Trial Update: Tipifarnib in Treating Young Patients With Recurrent or Progressive High-Grade Glioma, Medulloblastoma, Primitive Neuroectodermal Tumor, or Brain Stem Glioma [Phase 2]
Phase 2 clinical trial update evaluating tipifarnib in pediatric patients with recurrent or progressive brain tumors has completed, reportin…
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CLINICAL_TRIALS trial_result · 2013-09-30Clinical Trial Update: Temozolomide and O6-Benzylguanine in Treating Children With Recurrent Brain Tumors [Phase 1]
This Phase 1 trial evaluates the combination of temozolomide and O6-benzylguanine in pediatric patients with recurrent brain tumors.
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CLINICAL_TRIALS trial_result · 2013-06-24Clinical Trial Update: Pharmacologic Study of Methotrexate in Patients Undergoing Stereotactic Biopsy for Recurrent High-Grade Glioma [NA]
A completed clinical trial update describing a pharmacologic study of methotrexate in patients with recurrent high-grade glioma undergoing s…
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CLINICAL_TRIALS trial_result · 2013-05-14Clinical Trial Update: Borderzone Sampling [NA]
Clinical trial update noting completion of a Maastricht University Medical Center study on borderzone sampling in high-grade glioma and glio…
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CLINICAL_TRIALS trial_result · 2013-05-08Clinical Trial Update: Protocol to Distinguish Tumor Recurrence From Treatment-Related Necrosis in Patients With High Grade Gliomas
This completed clinical trial investigates a protocol to distinguish tumor recurrence from treatment-related necrosis in patients with recur…
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CLINICAL_TRIALS trial_result · 2013-02-18Clinical Trial Update: Carmustine Wafers Plus Irinotecan in Treating Patients With Recurrent Supratentorial High Grade Gliomas [Phase 1]
A Phase 1 clinical trial evaluating the combination of Carmustine wafers and Irinotecan for patients with recurrent supratentorial high-grad…
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CLINICAL_TRIALS trial_result · 2013-01-10Clinical Trial Update: Capecitabine and Radiation Therapy in Treating Young Patients With Newly Diagnosed, Nonmetastatic Brain Stem Glioma or High-Grade Glioma [Phase 1]
Phase 1 study of capecitabine with radiation therapy in young patients with newly diagnosed nonmetastatic brain stem glioma or high-grade gl…
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CLINICAL_TRIALS research · 2012-12-11Clinical Trial Update: Magnetic Resonance Imaging in Evaluating Response to RadiationTherapy in Patients With High Grade Glioma [NA]
This clinical trial investigates the use of MRI to evaluate response to radiation therapy in patients with high-grade glioma, and the study …
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CLINICAL_TRIALS trial_result · 2012-07-06Clinical Trial Update: Bevacizumab and Irinotecan to Treat Brain Tumors [Phase 2]
A Phase 2 trial evaluating bevacizumab in combination with irinotecan for high-grade gliomas was terminated, and results were posted in July…
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CLINICAL_TRIALS trial_result · 2012-06-08Clinical Trial Update: Bevacizumab for Recurrent Malignant Glioma [Phase 2]
A Phase 2 trial evaluating bevacizumab for recurrent malignant glioma reported results (posted in 2012).
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CLINICAL_TRIALS trial_result · 2012-05-04Clinical Trial Update: Assessment of 18FLT PET-CT for Volume Definition of High-grade Gliomas (GLIO-TEP) [Phase 1, Phase 2]
This clinical trial update assesses 18F-FLT PET-CT for defining tumor volumes in high-grade gliomas, including astrocytoma and glioblastoma,…
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CLINICAL_TRIALS trial_result · 2012-03-08Clinical Trial Update: Talampanel in Treating Patients With Recurrent High-Grade Glioma [Phase 2]
Phase 2 clinical trial of talampanel for recurrent high-grade glioma has completed.
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CLINICAL_TRIALS withdrawal · 2011-09-22Clinical Trial Update: Minimized Time to Beam in Patients With High Grade Gliomas [NA]
The clinical trial NCT00469534 evaluating minimizing time to beam in patients with high-grade glioma has been withdrawn.
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CLINICAL_TRIALS trial_result · 2010-08-12Clinical Trial Update: Trans Sodium Crocetinate (TSC) Study of Intra-tumoral Oxygen Concentration, Safety, and Pharmacokinetics in Patients With High Grade Glioma [Phase 1]
A Phase 1 study of Trans Sodium Crocetinate (TSC) in patients with high-grade glioma has been terminated. The update covers intra-tumoral ox…