High-grade Glioma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2018-04-30Clinical Trial Update: Phase I/II: Decitabine/Vaccine Therapy in Relapsed/Refractory Pediatric High Grade Gliomas/Medulloblastomas/CNS PNETs [Phase 1, Phase 2]
Phase I/II trial of decitabine with a vaccine therapy in relapsed/refractory pediatric high-grade gliomas, medulloblastoma, and CNS primitiv…
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CLINICAL_TRIALS trial_result · 2018-01-04Clinical Trial Update: A Study of Apatinib in Recurrent or Recurrent High-grade Glioma [Phase 2]
Phase 2 trial investigating apatinib in patients with recurrent high-grade glioma.
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CLINICAL_TRIALS trial_result · 2017-12-13Clinical Trial Update: Antineoplaston Therapy in Treating Children With Recurrent or Refractory High-Grade Glioma [Phase 2]
Phase 2 trial of antineoplaston therapy in children with recurrent or refractory high-grade glioma was terminated, with results posted in 20…
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CLINICAL_TRIALS trial_result · 2017-11-09Clinical Trial Update: A Pilot Feasibility Study of Oral 5-Fluorocytosine and Genetically-Modified Neural Stem Cells Expressing E.Coli Cytosine Deaminase for Treatment of Recurrent High Grade Gliomas [Phase 1]
Phase 1 feasibility trial evaluating oral 5-fluorocytosine in combination with genetically modified neural stem cells expressing E. coli cyt…
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CLINICAL_TRIALS trial_result · 2017-10-09Clinical Trial Update: Cellular Adoptive Immunotherapy Using Genetically Modified T-Lymphocytes in Treating Patients With Recurrent or Refractory High-Grade Malignant Glioma [Phase 1]
Phase 1 trial assessing adoptive immunotherapy with genetically modified T-lymphocytes for recurrent or refractory high-grade malignant glio…
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CLINICAL_TRIALS trial_result · 2017-08-29Clinical Trial Update: Personalized Translational Platform for Biomarker Discovery in Brain Tumors
A clinical trial investigating a personalized translational platform for biomarker discovery in high-grade glioma has completed.
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CLINICAL_TRIALS trial_result · 2017-08-22Clinical Trial Update: Radiation Planning Study for High Grade Brain Tumors
The University of Cincinnati-sponsored radiation planning study for high-grade glioma has completed.
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CLINICAL_TRIALS trial_result · 2017-08-04Clinical Trial Update: A Study of Bevacizumab (Avastin) in Combination With Temozolomide (TMZ) and Radiotherapy in Paediatric and Adolescent Participants With High-Grade Glioma [Phase 2]
Phase 2 clinical trial evaluating bevacizumab in combination with temozolomide and radiotherapy for pediatric and adolescent high-grade glio…
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CLINICAL_TRIALS trial_result · 2017-06-27Clinical Trial Update: Dasatinib and Bevacizumab in Treating Patients With Recurrent or Progressive High-Grade Glioma or Glioblastoma Multiforme [Phase 2]
Phase 2 trial evaluating dasatinib in combination with bevacizumab for recurrent or progressive high-grade glioma or glioblastoma multiforme…
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CLINICAL_TRIALS research · 2017-06-16Clinical Trial Update: Apatinib and Irinotecan in Treating Patients With Recurrent High-grade Glioma [Phase 1, Phase 2]
This ClinicalTrials.gov entry reports a Phase 1/Phase 2 study evaluating the combination of apatinib and irinotecan for recurrent high-grade…
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CLINICAL_TRIALS trial_result · 2017-05-09Clinical Trial Update: A Phase I/II Trial of BMS-247550 for Treatment of Patients With Recurrent High-Grade Gliomas [Phase 1, Phase 2]
Results from a Phase I/II trial of BMS-247550 for recurrent high-grade gliomas have been posted, evaluating adults with anaplastic astrocyto…
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CLINICAL_TRIALS trial_result · 2017-05-09Clinical Trial Update: A Phase II Study of Adjuvant Use of Anti-Epidermal Growth Factor Receptor EGFR-425 in High Grade Gliomas [Phase 2]
The document reports the completion of a Phase II trial evaluating adjuvant EGFR-425 therapy in high-grade gliomas.
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CLINICAL_TRIALS trial_result · 2017-04-26Clinical Trial Update: PDGFR Inhibitor Crenolanib in Children/Young Adults With Diffuse Intrinsic Pontine Glioma or Recurrent High-Grade Glioma [Phase 1]
Phase 1 trial of crenolanib, a PDGFR inhibitor, in pediatric patients with Diffuse Intrinsic Pontine Glioma or recurrent high-grade glioma h…
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CLINICAL_TRIALS trial_result · 2017-04-21Clinical Trial Update: Assessing Dynamic Magnetic Resonance (MR) Imaging in Patients With Recurrent High Grade Glioma Receiving Chemotherapy [Phase 1]
A Phase 1 study assessing dynamic magnetic resonance imaging in patients with recurrent high-grade glioma receiving chemotherapy; the study …
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CLINICAL_TRIALS research · 2017-04-05Clinical Trial Update: Differentiation of Progression From Treatment Effects in High-Grade Gliomas: A Clinical Trial With Multimodality MR Imaging
A clinical trial using multimodality MR imaging to distinguish progression from treatment effects in patients with high-grade glioma.
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CLINICAL_TRIALS trial_result · 2017-03-21Clinical Trial Update: Treatment of High-grade Gliomas Using Hypofractionated Radiation Therapy -a Phase I Clinical Trial [NA]
A completed Phase I trial evaluating hypofractionated radiation therapy for high-grade gliomas to determine safety and the maximum tolerated…
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CLINICAL_TRIALS trial_result · 2017-03-10Clinical Trial Update: Dendritic Cell Vaccine Therapy With In Situ Maturation in Pediatric Brain Tumors [Phase 1]
Phase 1 study of dendritic cell vaccine therapy with in situ maturation for pediatric brain tumors was terminated.
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CLINICAL_TRIALS research · 2017-02-20Clinical Trial Update: The Research on 89Zr-ABT806 PET Imaging in High Grade Glioma [NA]
Clinical trial update describing research on radiolabeled ABT-806 PET imaging with 89Zr in high-grade glioma, sponsored by Huashan Hospital.…
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CLINICAL_TRIALS withdrawal · 2017-02-09Clinical Trial Update: OXC401-PO1s/WVU 1309 - A Pilot Study of Fosbretabulin With Bevacizumab in Recurrent High-Grade Gliomas [Phase 1]
A Phase 1 pilot trial of OXC401 (fosbretabulin) with bevacizumab for recurrent high-grade gliomas has been withdrawn. The study involves cen…
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CLINICAL_TRIALS trial_result · 2017-01-27Clinical Trial Update: Short Course of Radiation for Gliomas in Elderly Patients [Phase 2]
Phase 2 trial evaluating a short course of radiation therapy for elderly patients with high-grade glioma has completed.
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CLINICAL_TRIALS trial_result · 2016-10-20Clinical Trial Update: Positron Emission Tomography (PET) With 3,4-dihydroxy-6-18F-fluoro-L-enylalanine (18F-FDOPA) Study [Phase 2]
Phase 2 study using the PET tracer 18F-FDOPA in high-grade glioma has completed.
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CLINICAL_TRIALS trial_result · 2016-05-20Clinical Trial Update: Hypofractionated Imrt (Vmat-Ra) For Elderly Patients With Newly Diagnosed High Grade Glioma [Phase 2]
A Phase 2 trial evaluating hypofractionated IMRT delivered with VMAT-Ra for elderly patients with newly diagnosed high-grade glioma has comp…
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CLINICAL_TRIALS trial_result · 2016-02-18Clinical Trial Update: Ultra-low Dose Bevacizumab Plus Temozolomide for Recurrent High-grade Gliomas [NA]
This document updates a clinical trial of ultra-low-dose bevacizumab plus temozolomide for recurrent high-grade glioma; the record lists no …
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CLINICAL_TRIALS trial_result · 2015-11-26Clinical Trial Update: Confocal Laser Endomicroscopy for Brain Tumors [Phase 1]
A Phase 1 trial evaluating confocal laser endomicroscopy for brain tumors (low-grade glioma and high-grade glioma) has been terminated.
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CLINICAL_TRIALS trial_result · 2015-11-06Clinical Trial Update: Temodar (Temozolomide), Bevacizumab, Lithium and Radiation for High Grade Glioma [Phase 2]
This Phase 2 trial evaluated temozolomide, bevacizumab, and lithium in combination with radiation for high-grade glioma; the study was termi…