High-grade Glioma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-03-16Clinical Trial Update: A Study on the Novel Oncolytic Virus Combined With PD-1 Inhibitor in the Treatment of Recurrent High-grade Glioma [Phase 1]
Phase 1 trial investigating a novel oncolytic virus in combination with a PD-1 inhibitor for recurrent high-grade glioma.
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion [EARLY_Phase 1]
A Phase 1 study assessing lorlatinib for newly diagnosed high-grade gliomas with ALK or ROS1 fusions; currently recruiting.
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: DB107-RRV, DB107-FC, and Radiation Therapy With or Without Temozolomide (TMZ) for High Grade Glioma [Phase 1, Phase 2]
Phase 1/2 clinical trial updating on DB107-RRV and DB107-FC with radiation therapy, with or without temozolomide, for high-grade glioma incl…
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CLINICAL_TRIALS research · 2026-03-09Clinical Trial Update: Integrating Biology for Safe Intensification of Glioblastoma Hypofractionated Treatment on the MR-Linac [Phase 1]
Phase 1 clinical trial exploring safe intensification of hypofractionated glioblastoma treatment on an MR-Linac; currently not yet recruitin…
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CLINICAL_TRIALS research · 2026-03-09Clinical Trial Update: AZD1390 in Recurrent and Newly Diagnosed WHO Grade 4 Glioma Patients [EARLY_Phase 1]
AZD1390 is being studied in an early-phase trial for recurrent and newly diagnosed WHO grade 4 gliomas (glioblastoma/high-grade glioma), wit…
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CLINICAL_TRIALS research · 2026-03-09Clinical Trial Update: RNA Lipid Particles Targeting Pediatric Recurrent Intracranial Malignancies and Other systEmic Solid Tumors [Phase 1, Phase 2]
Clinical trial update for RNA lipid particles targeting pediatric recurrent intracranial malignancies and other systemic solid tumors; Phase…
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CLINICAL_TRIALS research · 2026-03-06Clinical Trial Update: A Phase I Study of FZ-AD005 in Patients With High-Grade Glioma (HGG) [Phase 1]
This is a Phase 1 clinical trial update for the investigational drug FZ-AD005 in patients with high-grade glioma, including diffuse midline …
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CLINICAL_TRIALS research · 2026-03-05Clinical Trial Update: Circulating Tumor DNA Collection From Patients With High Grade Gliomas
ClinicalTrials.gov entry notes an ongoing study collecting circulating tumor DNA from patients with high-grade glioma; the trial is currentl…
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CLINICAL_TRIALS research · 2026-03-04Clinical Trial Update: Serial Advanced Magnetic Resonance Imaging Scan for Guidance of Personalized Adaptive Radiotherapy for High Grade Glioma
An ongoing MD Anderson Cancer Center trial evaluating serial advanced MRI to guide personalized adaptive radiotherapy for high-grade glioma;…
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: Window Trial of Fluorescently Labeled Nivolumab-IRDye800 (Nivo800) in High Grade Glioma (HGG) [EARLY_Phase 1]
An early-phase imaging trial evaluating fluorescently labeled nivolumab-IRDye800 (Nivo800) for high-grade glioma, with the study currently n…
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CLINICAL_TRIALS research · 2026-02-25Clinical Trial Update: Bevacizumab Versus Corticosteroids as First-line Treatment in Patients With Symptomatic Cerebral Radiation Necrosis After Radiation for High-grade Glioma or Brain Metastases [Phase 3]
Phase 3 clinical trial comparing bevacizumab to corticosteroids as first-line treatment for symptomatic cerebral radiation necrosis after ra…
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CLINICAL_TRIALS research · 2026-02-20Clinical Trial Update: Intratumoral DNX-2401 for High Grade Pediatric Brain Tumors [Phase 2]
A Phase 2 clinical trial of intratumoral DNX-2401 for pediatric high-grade brain tumors is not yet recruiting. The study targets high-grade …
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CLINICAL_TRIALS research · 2026-02-19Clinical Trial Update: Simulation-Based Caregiving Skills Training for Family Members of High Grade Glioma Patients [NA]
Clinical trial update for a simulation-based caregiving skills training program for family members of patients with high-grade glioma, curre…
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CLINICAL_TRIALS research · 2026-02-17Clinical Trial Update: Prospective Surgical Study on the Pattern of Electrical Activity in High Grade Glioma as a Predictor of Progression [Phase 1]
A Phase 1 prospective surgical study examining whether patterns of electrical activity in high-grade glioma can predict disease progression.
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CLINICAL_TRIALS research · 2026-02-05Clinical Trial Update: Combination ADI-PEG 20, TMZ, and RT for Treatment of Newly Diagnosed High-grade Glioma (HGG) [Phase 1, Phase 2]
A Phase 1/2 clinical trial is evaluating a combination of ADI-PEG 20, temozolomide, and radiotherapy for newly diagnosed high-grade glioma, …
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CLINICAL_TRIALS research · 2026-02-03Clinical Trial Update: A Trial of Dabrafenib, Trametinib and Hydroxychloroquine for Patients With Recurrent LGG or HGG With a BRAF Aberration [Phase 1, Phase 2]
Status update for a Phase 1/2 trial evaluating dabrafenib, trametinib, and hydroxychloroquine in patients with recurrent low-grade or high-g…
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CLINICAL_TRIALS research · 2026-01-27Clinical Trial Update: A Living Tissue Bank of Patient-Derived Organoids From Glioma Tumors
The study aims to establish a living tissue bank of patient-derived glioma organoids. Recruitment is ongoing for patients with low-grade gli…
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CLINICAL_TRIALS research · 2026-01-20Clinical Trial Update: Loc3CAR: Locoregional Delivery of B7-H3-CAR T Cells for Pediatric Patients With Primary CNS Tumors [Phase 1]
Clinical trial update indicating that Loc3CAR (B7-H3-CAR T cells) delivery is in early-phase pediatric CNS tumor trials and currently recrui…
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CLINICAL_TRIALS research · 2026-01-09Clinical Trial Update: Gallium Maltolate for the Treatment of Pediatric Patients With Relapsed or Refractory Pediatric High-Grade Glioma and Atypical Teratoid Rhabdoid Tumor [Phase 1]
This clinical trial update describes a Phase 1 study of gallium maltolate for relapsed or refractory pediatric high-grade glioma and atypica…
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CLINICAL_TRIALS research · 2026-01-02Clinical Trial Update: Concurrent XRD-0394 With Radiation Therapy for High Grade Gliomas [EARLY_Phase 1]
A Phase 1 early trial evaluating XRD-0394 in combination with radiation therapy for high-grade glioma is currently recruiting.
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CLINICAL_TRIALS research · 2026-01-02Clinical Trial Update: Concurrent Azeliragon With Craniospinal Irradiation [Phase 1]
A Phase 1 clinical trial evaluating azeliragon in combination with craniospinal irradiation for patients with high-grade glioma and leptomen…
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CLINICAL_TRIALS research · 2025-12-29Clinical Trial Update: A Phase I Clinical Trial of a mRNA Vaccine for Recurrent or Progressive High-grade Glioma [Phase 1]
This update describes a Phase I clinical trial of an mRNA vaccine for recurrent or progressive high-grade glioma that is currently recruitin…
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CLINICAL_TRIALS research · 2025-12-18Clinical Trial Update: Peds CHAMP1ON - Hematopoietic Stem Cell And Monoclonal Antibody PD-1 Blockade for RecurreNt Pediatric High-Grade Glioma [Phase 1]
A Phase 1 clinical trial in pediatric patients with recurrent high-grade glioma evaluating hematopoietic stem cell therapy in combination wi…
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CLINICAL_TRIALS research · 2025-12-18Clinical Trial Update: Telehealth Visits to Discuss Advanced Directives for Patients Newly Diagnosed With High Grade Glioma [NA]
A recruiting clinical trial at the University of Rochester is exploring telehealth visits to discuss advanced directives for patients newly …
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CLINICAL_TRIALS research · 2025-12-16Clinical Trial Update: Fluorescence Enhanced Stereotactic Surgery (FESS)
A clinical trial update indicates that a study evaluating fluorescence-enhanced stereotactic surgery for high-grade glioma is currently recr…