Gastroesophageal Junction Cancer
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2025-05-30Clinical Trial Update: Lenvatinib Plus Tislelizumab and CapeOX as First-Line Treatment for Advanced GC/GEJC With Positive PD-L1 and Low TMEscore [Phase 2]
Phase 2 clinical trial assessing first-line treatment with lenvatinib plus tislelizumab and CapeOX for advanced gastric/gastroesophageal jun…
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CLINICAL_TRIALS research · 2025-05-28Clinical Trial Update: Neoadjuvant Chemo-hypoRT Plus PD-1 Antibody (Tislelizumab) in Resectable LA-G/GEJ [Phase 2]
This clinical trial update describes a Phase 2 study evaluating neoadjuvant chemotherapy and hypofractionated radiotherapy combined with the…
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CLINICAL_TRIALS research · 2025-05-25Clinical Trial Update: Optimal Nutritional Palliation of Obstructed GEJ Cancer [NA]
ClinicalTrials.gov update describing a study on optimal nutritional palliation for obstructed gastroesophageal junction cancer, currently no…
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CLINICAL_TRIALS research · 2025-05-22Clinical Trial Update: Registry for Esophageal and Gastroesophageal Junction Cancer
This clinical trial registry entry indicates a Memorial Sloan Kettering Cancer Center study on esophageal cancer and gastroesophageal juncti…
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CLINICAL_TRIALS trial_result · 2025-05-16Clinical Trial Update: A Study of PET Scans With the Radioactive Tracer 18F-BMS-986229 in Patients With Esophageal, Stomach, or Gastroesophageal Junction Cancer
A completed clinical trial evaluating PET imaging with the radiotracer 18F-BMS-986229 in patients with cancers of the esophagus, stomach, or…
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CLINICAL_TRIALS research · 2025-05-07Clinical Trial Update: XELOX Combined With Sintilimab and HBO for Advanced or Metastatic GC/GEJC [Phase 1, Phase 2]
A Phase 1/2 trial evaluating XELOX (capecitabine plus oxaliplatin) in combination with sintilimab and hyperbaric oxygen therapy for advanced…
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CLINICAL_TRIALS trial_result · 2025-05-06Clinical Trial Update: A Study to Evaluate Safety, Tolerability, Dosimetry, and Preliminary Efficacy of the HER2 Directed Radioligand CAM-H2 in Patients With Advanced/Metastatic HER2-Positive Breast, Gastric, and Gastro-Esophageal Junction (GEJ) Cancer [Phase 1, Phase 2]
A phase 1/2 study evaluating CAM-H2, a HER2-directed radioligand, in advanced/metastatic HER2-positive breast, gastric, and gastroesophageal…
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CLINICAL_TRIALS research · 2025-05-06Clinical Trial Update: Total Neoadjuvant FLOT Chemotherapy in Locally Advanced Gastric and Gastroesophageal Junction Cancer [Phase 2, Phase 3]
A Phase 2/Phase 3 trial is evaluating total neoadjuvant FLOT chemotherapy for locally advanced gastric and gastroesophageal junction cancer;…
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CLINICAL_TRIALS trial_result · 2025-04-22Clinical Trial Update: Combination Margetuximab, Retifanlimab, Tebotelimab, and Chemotherapy Phase 2/3 Trial in HER2+ Gastric/GEJ Cancer [Phase 2, Phase 3]
This clinical trial update reports the completion of a Phase 2/3 study evaluating a four-drug combination (margetuximab, retifanlimab, tebot…
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CLINICAL_TRIALS research · 2025-04-18Clinical Trial Update: Evaluation of Efficacy and Safety De-escalation Versus Standard Adjuvant Chemotherapy in Patients With Low Risk Localized Gastroesophageal Adenocarcinoma [Phase 2]
Phase 2 clinical trial evaluating de-escalation versus standard adjuvant chemotherapy in patients with low-risk localized gastroesophageal c…
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CLINICAL_TRIALS research · 2025-04-16Clinical Trial Update: The Effect of Different Digestive Tract Reconstruction Methods on Postoperative Quality of Life After Proximal Gastrectomy
This clinical trial investigates how different digestive tract reconstruction methods after proximal gastrectomy affect patients' postoperat…
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CLINICAL_TRIALS research · 2025-04-06Clinical Trial Update: Efficacy of Tirellizumab Combined With Oral, Intravenous and Abdominal Chemotherapy in Peritoneal Metastatic Gastric/Gastroesophageal Junction Adenocarcinoma [Phase 2]
Phase 2 trial evaluating Tirellizumab combined with oral, IV, and intraperitoneal chemotherapy for gastric/gastroesophageal junction/esophag…
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CLINICAL_TRIALS trial_result · 2025-03-30Clinical Trial Update: A Trial of SHR1701 Plus Chemotherapy in Patients With Gastric or Gastroesophageal Cancer [Phase 3]
Phase 3 trial of SHR1701 plus chemotherapy for gastric or gastroesophageal junction cancer is currently active but not recruiting.
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CLINICAL_TRIALS trial_result · 2025-03-27Clinical Trial Update: OPPOSITE: Outcome Prediction of Systemic Treatment in Esophagogastric Carcinoma [NA]
Clinical trial OPPOSITE, studying outcome prediction of systemic treatment in esophagogastric carcinoma, has completed. The sponsor is Unive…
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CLINICAL_TRIALS trial_result · 2025-02-20Clinical Trial Update: Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy in Participants With Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (MK-3475-585/KEYNOTE-585)-China Extension [Phase 3]
This is the China extension of the Phase 3 KEYNOTE-585 trial evaluating pembrolizumab plus chemotherapy versus placebo plus chemotherapy in …
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CLINICAL_TRIALS trial_result · 2025-02-20Clinical Trial Update: Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy in Participants With Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (MK-3475-585/KEYNOTE-585) [Phase 3]
A Phase 3 trial (MK-3475-585/KEYNOTE-585) evaluating pembrolizumab plus chemotherapy versus chemotherapy alone in gastric cancer and gastroe…
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CLINICAL_TRIALS research · 2025-02-19Clinical Trial Update: Establishment of 2D and 3D Primary Cell Cultures From Gastric and Gastroesophageal Junction Cancer
The study aims to establish 2D and 3D primary cell cultures from gastric and gastroesophageal junction cancers. This setup supports future t…
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CLINICAL_TRIALS research · 2025-02-17Clinical Trial Update: A Multicenter Randomized Controlled Phase II Trial of Iparomlimab and Tuvonralimab (QL1706) Combined with SOX Chemotherapy Versus Chemotherapy Alone in the Treatment of Locally Advanced Gastric or Gastroesophageal Junction Adenocarcinoma [Phase 2]
A Phase II multicenter randomized trial evaluating iparomlimab and tuvonralimab (QL1706) added to SOX chemotherapy vs chemotherapy alone for…
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CLINICAL_TRIALS trial_result · 2025-02-14Clinical Trial Update: Tislelizumab in Combination With Chemotherapy as First-Line Treatment in Adults With Inoperable, Locally Advanced or Metastatic Gastric, or Gastroesophageal Junction Carcinoma [Phase 3]
Phase 3 trial evaluated tislelizumab in combination with chemotherapy as first-line treatment for adults with inoperable, locally advanced o…
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CLINICAL_TRIALS trial_result · 2025-02-10Clinical Trial Update: A Study of SGN-ALPV in Advanced Solid Tumors [Phase 1]
Seagen's Phase 1 study of SGN-ALPV in advanced solid tumors has been terminated; the trial evaluated multiple cancers including ovarian, end…
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CLINICAL_TRIALS research · 2025-02-07Clinical Trial Update: Immune Checkpoint Inhibitors (ICIs) Retreatment in Second-line Treatment of Advanced Gastric Cancer: a Retrospective, Real-world Study
A retrospective real-world study evaluating retreatment with immune checkpoint inhibitors as second-line therapy for advanced gastric cancer…
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CLINICAL_TRIALS research · 2025-02-05Clinical Trial Update: PD-1 Blockade With JS001 Plus Neoadjuvant Chemotherapy for Gastric/Gastroesophageal Junction Cancer [Phase 2]
A Phase 2 clinical trial evaluating JS001 in combination with neoadjuvant chemotherapy for gastric cancer and gastroesophageal junction canc…
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CLINICAL_TRIALS research · 2025-01-29Clinical Trial Update: A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors [Phase 1, Phase 2]
This clinical trial update describes a Phase 1/2 study of the bispecific antibody MCLA-158 in patients with advanced solid tumors. Recruitme…
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CLINICAL_TRIALS research · 2025-01-24Clinical Trial Update: Low-dose Radiotherapy Combined With Chemotherapy and AK112 as Second-line Treatment in Patients With Advanced G/GEJ Cancer [Phase 2]
Phase 2 trial evaluating low-dose radiotherapy combined with chemotherapy and AK112 as second-line treatment for advanced gastric and gastro…
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CLINICAL_TRIALS research · 2025-01-22Clinical Trial Update: The Relationship of Psychological Stress With Therapy Efficacy and Prognosis of Gastric Cancer
A clinical trial exploring how psychological stress influences therapy efficacy and prognosis in gastric cancer and gastroesophageal junctio…