Gastroesophageal Junction Cancer
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Substudy 06C: A Study of Investigational Agents With Pembrolizumab (MK-3475) and Chemotherapy in Participants With First-Line Locally Advanced Unresectable/Metastatic Gastroesophageal Adenocarcinoma (MK-3475-06C/KEYMAKER-U06) [Phase 1, Phase 2]
This is a clinical trial update indicating that Substudy 06C is evaluating pembrolizumab in combination with chemotherapy for first-line loc…
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: Study of Denikitug (GS-1811) Given Alone or With Nivolumab or Chemotherapy in Adults With Metastatic Gastric, Gastroesophageal Junction (GEJ), and Esophageal Adenocarcinomas [Phase 2]
Phase 2 clinical trial evaluating Denikitug (GS-1811) alone or with nivolumab or chemotherapy in adults with metastatic gastric, gastroesoph…
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: Study for AZD4360 in Participants With Advanced Solid Tumours [Phase 1, Phase 2]
Phase 1/2 clinical trial of AZD4360 in adults with advanced solid tumors, including gastric cancer and gastroesophageal junction cancer, is …
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: Adjuvant Trastuzumab Deruxtecan (Enhertu) & Nivolumab For Patients Who Are Disease Free After Completion of Trimodality Treatment For HER-2+ Cancers of Esophagus & Gastroesophageal Junction [Phase 2]
This clinical trial update notes a Phase 2 study of adjuvant trastuzumab deruxtecan (Enhertu) in combination with nivolumab for patients who…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Using 18F-FAPI PET to Detect Metastatic Disease in Patients That Have Gastric or Esophageal Cancer. [Phase 3]
Phase 3 clinical trial using 18F-FAPI PET imaging to detect metastatic disease in patients with gastric or esophageal cancer; recruitment is…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Gastroesophageal Cancer [Phase 2, Phase 3]
Pfizer is enrolling patients in a Phase 2/Phase 3 study testing PF-08634404 with chemotherapy for untreated advanced or metastatic gastric c…
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CLINICAL_TRIALS research · 2026-04-09Clinical Trial Update: Phase 2 Futibatinib in Combination With PD-1 Antibody Based Standard of Care in Solid Tumors [Phase 2]
Phase 2 study evaluating futibatinib in combination with a PD-1 antibody-based standard of care for locally advanced unresectable or metasta…
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: EIK1005-002: A Clinical Research Study Evaluating EIK1005, a Werner Helicase Inhibitor, as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors Including Microsatellite Instability High (MSI-H) Tumors [Phase 1, Phase 2]
This clinical trials update notes ongoing Phase 1/2 studies of EIK1005, a Werner helicase inhibitor, as monotherapy and in combination with …
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: Immunotherapy Combination: Irradiated PD-L1 CAR-NK Cells Plus Pembrolizumab Plus N-803 for Subjects With Recurrent/Metastatic Gastric or Head and Neck Cancer [Phase 2]
This clinical trial update describes a Phase 2 study evaluating irradiated PD-L1 CAR-NK cells in combination with pembrolizumab and N-803 fo…
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: A Study to Evaluate the Safety and the Activity of S095029 as Part of Combination Therapy in Advanced Gastroesophageal Junction/Gastric Cancers. [Phase 1, Phase 2]
This clinical trial update describes a Phase 1/2 study evaluating the safety and activity of S095029 in combination therapy for advanced gas…
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: A Study of Zolbetuximab (IMAB362) in Adults With Gastric Cancer [Phase 2]
Phase 2 clinical trial update on zolbetuximab (IMAB362) in adults with gastric cancer, including pharmacokinetic data and current non-recrui…
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CLINICAL_TRIALS research · 2026-04-02Clinical Trial Update: Substudy 06D: Combination Therapies in Second Line (2L) Gastroesophageal Adenocarcinoma (MK-3475-06D/Keymaker-U06) [Phase 1, Phase 2]
This document describes Substudy 06D of a Phase 1/2 clinical trial evaluating pembrolizumab in combination therapies for second-line gastroe…
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CLINICAL_TRIALS research · 2026-04-02Clinical Trial Update: A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Nivolumab in Combination With Chemotherapy in Participants With Previously Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma (ROSETTA Gastric-204) [Phase 2, Phase 3]
A Phase 2/3 clinical trial (ROSETTA Gastric-204) is evaluating Pumitamig plus chemotherapy versus Nivolumab plus chemotherapy as first-line …
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CLINICAL_TRIALS research · 2026-04-02Clinical Trial Update: Feasibility of Circulating Tumor DNA Based Minimal Residual Disease-Guided Adjuvant Therapy in Locally Advanced Gastric Cancer With Neoadjuvant Treatment [Phase 3]
Phase 3 clinical trial evaluating the feasibility of using circulating tumor DNA–based minimal residual disease to guide adjuvant therapy in…
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CLINICAL_TRIALS research · 2026-03-20Clinical Trial Update: Proximal Versus Total Gastrectomy for Locally Advanced Siewert Type II-III Gastroesophageal Junction Cancer [NA]
A clinical trial is recruiting to compare proximal versus total gastrectomy for locally advanced gastroesophageal junction cancer (Siewert T…
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CLINICAL_TRIALS research · 2026-03-18Clinical Trial Update: A First-in-human Study of BGB-53038, a Pan-KRAS Inhibitor, Alone or in Combinations in Participants With Advanced or Metastatic Solid Tumors With KRAS Mutations or Amplification [Phase 1]
BeiGene is conducting a first-in-human Phase 1 study of BGB-53038, a pan-KRAS inhibitor, as a monotherapy or in combination, in participants…
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CLINICAL_TRIALS research · 2026-03-18Clinical Trial Update: CA-4948 in Combination With FOLFOX/PD-1 Inhibitor +/- Trastuzumab for Untreated Unresectable Gastric and Esophageal Cancer [Phase 1]
A Phase 1 trial is evaluating CA-4948 in combination with FOLFOX and a PD-1 inhibitor, with or without trastuzumab, for untreated unresectab…
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CLINICAL_TRIALS research · 2026-03-17Clinical Trial Update: A Study to Investigate the Effects of AZD0901 Monotherapy in Adult Participants With 2L+ Advanced or Metastatic Gastric or GEJ Adenocarcinoma Expressing CLDN18.2 [Phase 2]
Phase 2 trial evaluating AZD0901 as monotherapy in adults with 2L+ advanced or metastatic gastric or GEJ adenocarcinoma expressing CLDN18.2.…
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CLINICAL_TRIALS research · 2026-03-16Clinical Trial Update: Study of TDXd, Chemotherapy, Pembrolizumab, and Trastuzumab in First-Line Metastatic HER2-Positive Gastric or Gastroesophageal Junction Cancer [Phase 3]
A Phase 3 clinical trial is evaluating a first-line combination of trastuzumab deruxtecan (TDXd), chemotherapy, pembrolizumab, and trastuzum…
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CLINICAL_TRIALS research · 2026-03-16Clinical Trial Update: Disitamab Vedotin Combined With SOX Regimen Versus SOX Alone as Adjuvant Therapy for HER2-Moderate/High Expressing Stage Ⅲ Gastric Cancer: A Prospective, Multicenter, Randomized, Phase Ⅱ Clinical Trial [Phase 2]
A Phase II randomized trial is evaluating disitamab vedotin plus the SOX chemotherapy regimen versus SOX alone as adjuvant therapy in HER2-e…
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: A Study to Observe the Safety of VYLOY (Zolbetuximab) in People in South Korea With Gastric or Gastroesophageal Junction Cancer.
A clinical trial update showing a safety study of zolbetuximab (VYLOY) in South Korea for gastric and gastroesophageal junction cancers, cur…
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CLINICAL_TRIALS research · 2026-03-09Clinical Trial Update: AZD0901 Compared With Investigator's Choice of Therapy in Participants With Second- or Later-line Advanced or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma Expressing Claudin18.2 [Phase 3]
Phase 3 trial comparing AZD0901 to investigator's choice of therapy in second- or later-line advanced or metastatic gastric or gastroesophag…
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CLINICAL_TRIALS research · 2026-03-05Clinical Trial Update: Study of TJ033721 (Givastomig) in Subjects With Advanced or Metastatic Solid Tumors [Phase 1]
Phase 1 trial evaluating TJ033721 (Givastomig) in adults with advanced or metastatic solid tumors; the study is currently recruiting and inc…
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: A Phase Ⅲ Clinical Study of HLX22 in Combination With Trastuzumab and Chemotherapy for the Treatment of Gastroesophageal Junction and Gastric Cancer [Phase 3]
Phase 3 clinical trial evaluating HLX22 in combination with trastuzumab and chemotherapy for gastroesophageal junction and gastric cancer, c…
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: Individually Tailored, Supervised, Remote Exercise Intervention to Improve Physical Function for Stage I-III Gastroesophageal Cancer Survivors, PRECISE Trial [NA]
The PRECISE trial is investigating a tailored, supervised, remote exercise program to improve physical function in Stage I-III gastroesophag…