Gastroesophageal Junction Cancer
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-07-30Clinical Trial Results: Study of Oxaliplatin and Xeloda and Cetuximab as First Line Treatment for Metastatic or Unresectable Gastric or Gastroesophageal Junction Cancer [Phase 2]
Phase 2 trial evaluating a combination of oxaliplatin, Xeloda (capecitabine), and cetuximab for first-line treatment of metastatic or unrese…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Substudy 06C: A Study of Investigational Agents With Pembrolizumab (MK-3475) and Chemotherapy in Participants With First-Line Locally Advanced Unresectable/Metastatic Gastroesophageal Adenocarcinoma (MK-3475-06C/KEYMAKER-U06) [Phase 1, Phase 2]
This is a clinical trial update indicating that Substudy 06C is evaluating pembrolizumab in combination with chemotherapy for first-line loc…
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: Study of Denikitug (GS-1811) Given Alone or With Nivolumab or Chemotherapy in Adults With Metastatic Gastric, Gastroesophageal Junction (GEJ), and Esophageal Adenocarcinomas [Phase 2]
Phase 2 clinical trial evaluating Denikitug (GS-1811) alone or with nivolumab or chemotherapy in adults with metastatic gastric, gastroesoph…
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: Study for AZD4360 in Participants With Advanced Solid Tumours [Phase 1, Phase 2]
Phase 1/2 clinical trial of AZD4360 in adults with advanced solid tumors, including gastric cancer and gastroesophageal junction cancer, is …
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: Adjuvant Trastuzumab Deruxtecan (Enhertu) & Nivolumab For Patients Who Are Disease Free After Completion of Trimodality Treatment For HER-2+ Cancers of Esophagus & Gastroesophageal Junction [Phase 2]
This clinical trial update notes a Phase 2 study of adjuvant trastuzumab deruxtecan (Enhertu) in combination with nivolumab for patients who…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Using 18F-FAPI PET to Detect Metastatic Disease in Patients That Have Gastric or Esophageal Cancer. [Phase 3]
Phase 3 clinical trial using 18F-FAPI PET imaging to detect metastatic disease in patients with gastric or esophageal cancer; recruitment is…
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CLINICAL_TRIALS trial_result · 2026-04-17Clinical Trial Update: A Phase 1b/2 Clinical Trial Evaluating the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of AUR103 Calcium in Patients With HER2-positive Advanced Gastric/Gastroesophageal Junction Adenocarcinoma [Phase 1, Phase 2]
Phase 1b/2 trial of AUR103 calcium in HER2-positive advanced gastric cancer and gastroesophageal junction adenocarcinoma has been terminated…
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CLINICAL_TRIALS trial_result · 2026-04-15Clinical Trial Update: An Umbrella Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Gastric or Gastroesophageal Junction Carcinoma [Phase 1, Phase 2]
This Roche umbrella Phase 1/2 trial evaluating multiple treatment combinations in gastric and gastroesophageal junction carcinoma was termin…
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CLINICAL_TRIALS trial_result · 2026-04-13Clinical Trial Update: Clinical Study of Adebrelimab Therapy in the Perioperative Treatment of Gastric Cancer or Gastroesophageal Junction Cancer [Phase 3]
A Phase 3 clinical trial evaluating Adebrelimab as perioperative therapy for locally advanced gastric or gastroesophageal junction cancer is…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Gastroesophageal Cancer [Phase 2, Phase 3]
Pfizer is enrolling patients in a Phase 2/Phase 3 study testing PF-08634404 with chemotherapy for untreated advanced or metastatic gastric c…
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CLINICAL_TRIALS research · 2026-04-09Clinical Trial Update: Phase 2 Futibatinib in Combination With PD-1 Antibody Based Standard of Care in Solid Tumors [Phase 2]
Phase 2 study evaluating futibatinib in combination with a PD-1 antibody-based standard of care for locally advanced unresectable or metasta…
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: EIK1005-002: A Clinical Research Study Evaluating EIK1005, a Werner Helicase Inhibitor, as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors Including Microsatellite Instability High (MSI-H) Tumors [Phase 1, Phase 2]
This clinical trials update notes ongoing Phase 1/2 studies of EIK1005, a Werner helicase inhibitor, as monotherapy and in combination with …
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: Immunotherapy Combination: Irradiated PD-L1 CAR-NK Cells Plus Pembrolizumab Plus N-803 for Subjects With Recurrent/Metastatic Gastric or Head and Neck Cancer [Phase 2]
This clinical trial update describes a Phase 2 study evaluating irradiated PD-L1 CAR-NK cells in combination with pembrolizumab and N-803 fo…
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: A Study to Evaluate the Safety and the Activity of S095029 as Part of Combination Therapy in Advanced Gastroesophageal Junction/Gastric Cancers. [Phase 1, Phase 2]
This clinical trial update describes a Phase 1/2 study evaluating the safety and activity of S095029 in combination therapy for advanced gas…
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: A Study of Zolbetuximab (IMAB362) in Adults With Gastric Cancer [Phase 2]
Phase 2 clinical trial update on zolbetuximab (IMAB362) in adults with gastric cancer, including pharmacokinetic data and current non-recrui…
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CLINICAL_TRIALS trial_result · 2026-04-03Clinical Trial Update: A Study of Trastuzumab in Combination With Capecitabine and Cisplatin in Patients With Tissue HER2- But Serum HER2+ AGC [Phase 2]
A Phase 2 trial evaluating trastuzumab in combination with capecitabine and cisplatin in patients with tissue HER2-negative but serum HER2-p…
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CLINICAL_TRIALS research · 2026-04-02Clinical Trial Update: Substudy 06D: Combination Therapies in Second Line (2L) Gastroesophageal Adenocarcinoma (MK-3475-06D/Keymaker-U06) [Phase 1, Phase 2]
This document describes Substudy 06D of a Phase 1/2 clinical trial evaluating pembrolizumab in combination therapies for second-line gastroe…
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CLINICAL_TRIALS research · 2026-04-02Clinical Trial Update: A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Nivolumab in Combination With Chemotherapy in Participants With Previously Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma (ROSETTA Gastric-204) [Phase 2, Phase 3]
A Phase 2/3 clinical trial (ROSETTA Gastric-204) is evaluating Pumitamig plus chemotherapy versus Nivolumab plus chemotherapy as first-line …
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CLINICAL_TRIALS research · 2026-04-02Clinical Trial Update: Feasibility of Circulating Tumor DNA Based Minimal Residual Disease-Guided Adjuvant Therapy in Locally Advanced Gastric Cancer With Neoadjuvant Treatment [Phase 3]
Phase 3 clinical trial evaluating the feasibility of using circulating tumor DNA–based minimal residual disease to guide adjuvant therapy in…
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CLINICAL_TRIALS research · 2026-03-20Clinical Trial Update: Proximal Versus Total Gastrectomy for Locally Advanced Siewert Type II-III Gastroesophageal Junction Cancer [NA]
A clinical trial is recruiting to compare proximal versus total gastrectomy for locally advanced gastroesophageal junction cancer (Siewert T…
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CLINICAL_TRIALS trial_result · 2026-03-19Clinical Trial Update: Treatment of Cabotamig (ARB202) in Advanced Gastrointestinal Cancer Patients [Phase 1]
Phase 1 trial of Cabotamig (ARB202) in advanced gastrointestinal cancers has completed; no specific efficacy results are provided in the doc…
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CLINICAL_TRIALS other · 2026-03-19Clinical Trial Update: IBI343 in Combination With Sintilimab and SOX Regimen for Perioperative Treatment of Resectable, Locally Advanced Gastric or Gastroesophageal Junction Adenocarcinoma [Phase 2]
Phase 2 trial update for IBI343 in combination with sintilimab and the SOX regimen for perioperative treatment of resectable, locally advanc…
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CLINICAL_TRIALS trial_result · 2026-03-18Clinical Trial Update: PReoperative Chemoradiation (Paclitaxel-carboplatin or FOLFOX) for Resectable Esophageal and Junctional Cancer [Phase 2]
A Phase 2 study evaluating preoperative chemoradiation with either paclitaxel-carboplatin or FOLFOX for resectable esophageal and gastroesop…
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CLINICAL_TRIALS research · 2026-03-18Clinical Trial Update: A First-in-human Study of BGB-53038, a Pan-KRAS Inhibitor, Alone or in Combinations in Participants With Advanced or Metastatic Solid Tumors With KRAS Mutations or Amplification [Phase 1]
BeiGene is conducting a first-in-human Phase 1 study of BGB-53038, a pan-KRAS inhibitor, as a monotherapy or in combination, in participants…
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CLINICAL_TRIALS research · 2026-03-18Clinical Trial Update: CA-4948 in Combination With FOLFOX/PD-1 Inhibitor +/- Trastuzumab for Untreated Unresectable Gastric and Esophageal Cancer [Phase 1]
A Phase 1 trial is evaluating CA-4948 in combination with FOLFOX and a PD-1 inhibitor, with or without trastuzumab, for untreated unresectab…