Diffuse Intrinsic Pontine Glioma
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CLINICAL_TRIALS research · 2025-03-30Clinical Trial Update: Safety and Efficacy of Loco-regional B7H3 IL-7Ra CAR T Cell in DIPG [Phase 1]
Phase 1 trial evaluating the safety and early efficacy of loco-regional B7H3 IL-7Ra CAR T cells for diffuse intrinsic pontine glioma (DIPG) …
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CLINICAL_TRIALS trial_result · 2025-03-07Clinical Trial Update: Gemcitabine in Newly-Diagnosed Diffuse Intrinsic Pontine Glioma [EARLY_Phase 1]
The Phase 1 trial evaluating gemcitabine in newly diagnosed Diffuse Intrinsic Pontine Glioma has completed. The study was sponsored by the U…
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CLINICAL_TRIALS research · 2025-02-21Clinical Trial Update: Study of Olutasidenib and Temozolomide in HGG [Phase 2]
Phase 2 study evaluating olutasidenib in combination with temozolomide for high-grade gliomas is currently recruiting.
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CLINICAL_TRIALS trial_result · 2025-02-19Clinical Trial Update: INCB7839 in Treating Children With Recurrent/Progressive High-Grade Gliomas [Phase 1]
Phase 1 trial of INCB7839 in children with recurrent or progressive high-grade gliomas has completed and results have been posted.
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CLINICAL_TRIALS trial_result · 2025-02-14Clinical Trial Update: ONC201 in Pediatric H3 K27M Gliomas [Phase 1]
Phase 1 trial update of ONC201 in pediatric H3 K27M gliomas including Diffuse Intrinsic Pontine Glioma and malignant glioma has been termina…
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CLINICAL_TRIALS research · 2025-02-05Clinical Trial Update: GD2-CAR T Cells for Pediatric Brain Tumours [Phase 1]
Phase 1 trial evaluating GD2-CAR T cells for pediatric brain tumors is currently recruiting. The study targets medulloblastoma, embryonal tu…
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CLINICAL_TRIALS trial_result · 2025-01-22Clinical Trial Update: H3.3K27M Peptide Vaccine With Nivolumab for Children With Newly Diagnosed DIPG and Other Gliomas [Phase 1, Phase 2]
Clinical trial results update for a combined H3.3K27M peptide vaccine and nivolumab in children with newly diagnosed Diffuse Intrinsic Ponti…
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CLINICAL_TRIALS research · 2025-01-14Clinical Trial Update: Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors [Phase 2]
Phase 2 pediatric trial evaluating palbociclib in combination with chemotherapy for recurrent or refractory solid tumors, including Ewing sa…
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CLINICAL_TRIALS research · 2024-12-27Clinical Trial Update: Clinical Trial to Assess the Safety and Efficacy of AloCELYVIR With Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) in Combination With Radiotherapy or Medulloblastoma in Monotherapy [Phase 1, Phase 2]
Clinical trial evaluating AloCELYVIR for newly diagnosed diffuse intrinsic pontine glioma in combination with radiotherapy and pediatric med…
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CLINICAL_TRIALS trial_result · 2024-12-24Clinical Trial Update: Oral AMXT 1501 Dicaprate in Combination With IV DFMO [Phase 1, Phase 2]
A Phase 1/2 trial of oral AMXT 1501 dicaprate in combination with IV DFMO has been terminated.
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CLINICAL_TRIALS trial_result · 2024-12-20Clinical Trial Update: A Study of BXQ-350 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) or Diffuse Midline Glioma (DMG) [Phase 1]
Phase 1 trial evaluating BXQ-350 in children with newly diagnosed diffuse intrinsic pontine glioma and diffuse midline glioma (H3 K27M-mutan…
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CLINICAL_TRIALS trial_result · 2024-12-06Clinical Trial Update: A Pilot Study of Glioma Associated Antigen Vaccines in Conjunction with Poly-ICLC in Pediatric Gliomas [Phase 1]
This Phase 1 pilot trial evaluated glioma-associated antigen vaccines with the Toll-like receptor 3 agonist Poly-ICLC in pediatric gliomas a…
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CLINICAL_TRIALS trial_result · 2024-12-05Clinical Trial Update: Re-Irradiation of Progressive or Recurrent DIPG [NA]
A completed clinical trial investigating re-irradiation for recurrent or progressive diffuse intrinsic pontine glioma (DIPG) conducted by th…
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CLINICAL_TRIALS trial_result · 2024-11-08Clinical Trial Update: Expanded Access to OKN-007 for Patients With Diffuse Midline Glioma, H3 K27-altered
Expanded Access for OKN-007 in patients with diffuse midline glioma (H3 K27-altered) and diffuse intrinsic pontine glioma is no longer avail…
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CLINICAL_TRIALS trial_result · 2024-10-10Clinical Trial Update: Phase I Study of APX005M in Pediatric Central Nervous System Tumors [Phase 1]
Phase I study of APX005M in pediatric central nervous system tumors; the trial is active but not recruiting and results have been posted. Sp…
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CLINICAL_TRIALS trial_result · 2024-10-09Clinical Trial Update: REGN2810 in Pediatric Patients With Relapsed, Refractory Solid, or Central Nervous System (CNS) Tumors and Safety and Efficacy of REGN2810 in Combination With Radiotherapy in Pediatric Patients With Newly Diagnosed or Recurrent Glioma [Phase 1, Phase 2]
Regeneron’s cemiplimab (REGN2810) was studied in pediatric patients with relapsed/refractory solid tumors and CNS tumors, including a safety…
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: A Phase 2 Study of Sonodynamic Therapy Using SONALA-001 and Exablate 4000 Type 2.0 in Patients with DIPG [Phase 2]
Phase 2 study of SONALA-001 with Exablate 4000 Type 2.0 for diffuse intrinsic pontine glioma and diffuse midline glioma has been suspended.
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CLINICAL_TRIALS research · 2024-08-20Clinical Trial Update: Molecular Analysis of Samples From Patients With Diffuse Intrinsic Pontine Glioma and Brainstem Glioma
A clinical trial update describing molecular analyses of samples from patients with diffuse intrinsic pontine glioma and brainstem glioma to…
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CLINICAL_TRIALS withdrawal · 2024-07-16Clinical Trial Update: Single Patient Compassionate Use / Expanded Access L-S-Gboxin (Lyophilized Form of S-Gboxin) for the Treatment of Diffuse Midline Glioma
Single-patient compassionate-use/expanded-access study of L-S-Gboxin for diffuse midline glioma is no longer available.
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CLINICAL_TRIALS trial_result · 2024-07-05Clinical Trial Update: A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas [Phase 1, Phase 2]
A Phase I/Phase II study evaluating mebendazole for pediatric gliomas has completed. It enrolled children with various glial tumors, includi…
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CLINICAL_TRIALS research · 2024-05-08Clinical Trial Update: Adjuvant Dendritic Cell Immunotherapy for Pediatric Patients With High-grade Glioma or Diffuse Intrinsic Pontine Glioma [Phase 1, Phase 2]
Phase 1/2 trial evaluating adjuvant dendritic cell immunotherapy in pediatric high-grade glioma and diffuse intrinsic pontine glioma; the st…
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CLINICAL_TRIALS research · 2024-05-02Clinical Trial Update: Clinical Study of Allogeneic Vγ9Vδ2 T Cells in the Treatment of Brain Malignant Glioma [EARLY_Phase 1]
This entry describes an early-stage Phase 1 clinical study evaluating allogeneic Vγ9Vδ2 T cells for malignant gliomas, including glioblastom…
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CLINICAL_TRIALS research · 2024-04-30Clinical Trial Update: xPedite: A Study to Expedite DIPG and DMG Research
The sponsor xCures reports a clinical trial called xPedite to expedite DIPG and DMG research. The study is currently recruiting.
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CLINICAL_TRIALS trial_result · 2024-04-25Clinical Trial Update: Trial of Panobinostat in Children With Diffuse Intrinsic Pontine Glioma [Phase 1]
Phase 1 trial of panobinostat in children with diffuse intrinsic pontine glioma has completed. Results have been posted.
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CLINICAL_TRIALS trial_result · 2024-01-03Clinical Trial Update: Adavosertib and Local Radiation Therapy in Treating Children With Newly Diagnosed Diffuse Intrinsic Pontine Gliomas [Phase 1]
Phase 1 trial evaluating adavosertib with local radiation in children with newly diagnosed diffuse intrinsic pontine glioma; results are pos…