Granulomatous Disease
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: NADPH Oxidase Correction in mRNA-transfected Granulocyte-enriched Cells in Chronic Granulomatous Disease (CGD) [Phase 1]
Phase 1 clinical trial investigating NADPH oxidase correction in mRNA-transfected granulocyte-enriched cells for Chronic Granulomatous Disea…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Lentiviral Gene Therapy for CGD [NA]
A clinical trial is recruiting to evaluate a lentiviral gene therapy for Chronic Granulomatous Disease.
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CLINICAL_TRIALS trial_result · 2026-04-24Clinical Trial Update: Analysis of Patients Treated for Chronic Granulomatous Disease Since January 1, 1995
This document presents a completed analysis of patients treated for Chronic Granulomatous Disease since January 1, 1995.
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CLINICAL_TRIALS trial_result · 2026-04-24Clinical Trial Update: Genetic Disorders of Mucociliary Clearance in Nontuberculous Mycobacterial Lung Disease
This completed NHLBI study examined genetic disorders that affect mucociliary clearance in nontuberculous mycobacterial lung disease, includ…
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: Safety and Efficacy of Tofacitinib for Chronic Granulomatous Disease With Inflammatory Complications [Phase 1, Phase 2]
An ongoing Phase 1/2 clinical trial is evaluating the safety and efficacy of tofacitinib for Chronic Granulomatous Disease with inflammatory…
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CLINICAL_TRIALS trial_result · 2026-04-20Clinical Trial Update: High Dose Peripheral Blood Stem Cell Transplantation With Post Transplant Cyclophosphamide for Patients With Chronic Granulomatous Disease [Phase 1, Phase 2]
This clinical trial update reports on a phase 1/2 study of high-dose peripheral blood stem cell transplantation with post-transplant cycloph…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Haploidentical Transplant for People With Chronic Granulomatous Disease (CGD) Using Alemtuzumab, Busulfan and TBI With Post-Transplant Cyclophosphamide [EARLY_Phase 1]
Clinical trial update on an early-phase haploidentical transplant approach for chronic granulomatous disease using alemtuzumab, busulfan, to…
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CLINICAL_TRIALS research · 2026-04-06Clinical Trial Update: Base Editing for Mutation Repair in Hematopoietic Stem & Progenitor Cells for X-Linked Chronic Granulomatous Disease [Phase 1, Phase 2]
A Phase 1/2 clinical trial is evaluating base editing of hematopoietic stem and progenitor cells to repair mutations causing X-linked chroni…
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CLINICAL_TRIALS research · 2026-04-06Clinical Trial Update: Part B- G1X-CGD (Lentiviral Vector Transduced CD34+ Cells) in Patients With X-Linked Chronic Granulomatous Disease [Phase 1, Phase 2]
Ongoing Phase 1/2 clinical trial evaluating G1X-CGD, a lentiviral vector–transduced CD34+ cell therapy for X-linked Chronic Granulomatous Di…
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CLINICAL_TRIALS research · 2026-04-06Clinical Trial Update: A Study of the Safety and Efficacy of Prime Editing (PM359) in Participants With p47phox Autosomal Recessive Chronic Granulomatous Disease (CGD ) [Phase 1, Phase 2]
Prime Medicine is conducting a Phase 1/2 study to evaluate the safety and efficacy of PM359, a prime editing therapy, in participants with p…
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CLINICAL_TRIALS research · 2026-04-02Clinical Trial Update: Evaluation of Patients With Immune Function Abnormalities
The NIAID-sponsored study evaluating patients with immune function abnormalities (chronic granulomatous disease, X-linked severe combined im…
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CLINICAL_TRIALS research · 2026-04-01Clinical Trial Update: Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Granulomatous Disease (CGD) With an Alemtuzumab, Busulfan and TBI-based Conditioning Regimen Combined With Cytokine (IL-6, +/- IFN-gamma) Antagonists [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating allogeneic hematopoietic stem cell transplantation for chronic granulomatous disease using alemtuzumab…
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CLINICAL_TRIALS research · 2026-04-01Clinical Trial Update: Recruitment and Apheresis Collection of Peripheral Blood Hematopoietic Stem Cells, Mononuclear Cells and Granulocytes
NIAID-sponsored clinical trial is recruiting to study recruitment and apheresis collection of peripheral blood hematopoietic stem cells, mon…
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CLINICAL_TRIALS research · 2026-03-03Clinical Trial Update: Prevalence of Antibodies and Cytokines in Participants With Chronic Granulomatous Disease
An ongoing clinical trial sponsored by Ensoma is evaluating the prevalence of antibodies and cytokines in participants with Chronic Granulom…
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CLINICAL_TRIALS trial_result · 2026-02-23Clinical Trial Update: pCCLCHIM-p47 (Lentiviral Vector Transduced CD34 Plus Cells) in Patients With p47 Autosomal Recessive Chronic Granulomatous Disease (AR-CGD) [Phase 1, Phase 2]
Phase 1/2 clinical trial evaluating pCCLCHIM-p47 lentiviral vector-transduced CD34+ cells for p47 Autosomal Recessive Chronic Granulomatous …
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CLINICAL_TRIALS research · 2026-02-19Clinical Trial Update: Immune Disorder HSCT Protocol [Phase 2]
Phase 2 clinical trial update on a hematopoietic stem cell transplant protocol for several inherited immune deficiency disorders; the study …
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CLINICAL_TRIALS trial_result · 2026-01-15Clinical Trial Update: Allogeneic Hematopoietic Stem Cell Transplant for Patients With Primary Immune Deficiencies [NA]
This clinical trial investigates allogeneic hematopoietic stem cell transplantation as a treatment for primary immune deficiencies, includin…
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CLINICAL_TRIALS trial_result · 2025-12-15Clinical Trial Update: Sequential Cadaveric Lung and Bone Marrow Transplant for Immune Deficiency Diseases [Phase 1, Phase 2]
This clinical trial update describes an early-phase study evaluating sequential cadaveric lung transplantation followed by bone marrow trans…
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CLINICAL_TRIALS trial_result · 2025-12-11Clinical Trial Update: Elemental Diet for Treatment of Inflammatory Bowel Disease in Patients With Chronic Granulomatous Disease [Phase 2]
Phase 2 clinical trial evaluating an elemental diet for inflammatory bowel disease in patients with chronic granulomatous disease has comple…
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CLINICAL_TRIALS withdrawal · 2025-09-25Clinical Trial Update: Gene Therapy for Chronic Granulomatous Disease in Korea [Phase 1, Phase 2]
A Phase 1/2 gene therapy trial for chronic granulomatous disease conducted by Helixmith in Korea has been withdrawn.
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CLINICAL_TRIALS research · 2025-08-26Clinical Trial Update: Study to Assess the Use of JSP191 in Matched Unrelated Donor Transplantation for Chronic Granulomatous Disease (CGD) [EARLY_Phase 1]
This is an early-phase 1 clinical trial update assessing JSP191 in matched unrelated donor transplantation for Chronic Granulomatous Disease…
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CLINICAL_TRIALS trial_result · 2025-05-02Clinical Trial Update: Study of Gene Therapy Using a Lentiviral Vector to Treat X-linked Chronic Granulomatous Disease [Phase 1, Phase 2]
A Phase 1/2 clinical trial using a lentiviral vector gene therapy to treat X-linked chronic granulomatous disease has completed.
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CLINICAL_TRIALS withdrawal · 2024-12-13Clinical Trial Update: Skin Immunity Sample Collection Involving Blisters and Biopsies [EARLY_Phase 1]
A Phase 1 clinical trial involving skin immunity sample collection for patients with Hyper-Immunoglobulin E Syndrome and Chronic Granulomato…
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CLINICAL_TRIALS trial_result · 2024-07-09Clinical Trial Update: Vitamin D3 For CGD Patients With BCGosis/Itis [Phase 2, Phase 3]
Clinical trial update reports completion of Phase 2/3 studies evaluating Vitamin D3 for chronic granulomatous disease patients with BCG-rela…
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CLINICAL_TRIALS trial_result · 2023-09-15Clinical Trial Update: Conditioning Regimen for Allogeneic Hematopoietic Stem-Cell Transplantation [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating conditioning regimens for allogeneic hematopoietic stem-cell transplantation has completed recruitment…