Amyotrophic Lateral Sclerosis
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CLINICAL_TRIALS research · 2025-12-01Clinical Trial Update: Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Tablet-01) [NA]
This ClinicalTrials.gov entry documents a feasibility study of the BrainGate2 Neural Interface System in individuals with tetraplegia and re…
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CLINICAL_TRIALS research · 2025-11-26Clinical Trial Update: Development and Test of a Headset for BCI Until Obtaining an Efficient and Comfortable System That Can be Used in Daily Practice by ALS People [NA]
This clinical trial update describes the development and testing of a brain-computer interface headset intended for daily use by people with…
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CLINICAL_TRIALS research · 2025-11-25Clinical Trial Update: Omics Sciences for the Identification of Pathogenetic Mechanisms and Biomarkers in Neurodegenerative Diseases
A clinical trial conducted by Ospedale Policlinico San Martino is currently recruiting to investigate pathogenetic mechanisms and biomarkers…
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CLINICAL_TRIALS other · 2025-11-21Clinical Trial Update: The Safety, Tolerability and Preliminary Efficacy of Derived Motor Neuron Progenitor Cells (XS228CN) in Subjects With Amyotrophic Lateral Sclerosis [Phase 1]
Phase 1 clinical trial update indicates XS228CN-derived motor neuron progenitor cells are being tested in ALS for safety, tolerability, and …
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CLINICAL_TRIALS trial_result · 2025-11-21Clinical Trial Update: Study of Gene Polymorphisms Involved in the Metabolism and Action of Vitamin D in Amyotrophic Lateral Sclerosis
A completed clinical trial investigating gene polymorphisms involved in Vitamin D metabolism and action in Amyotrophic Lateral Sclerosis.
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CLINICAL_TRIALS research · 2025-11-21Clinical Trial Update: Target ALS Biomarker Study; Longitudinal Biofluids, Clinical Measures, and At Home Measures
This clinical trial update describes the Target ALS biomarker study investigating longitudinal biofluids, clinical measures, and at-home ass…
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CLINICAL_TRIALS research · 2025-11-20Clinical Trial Update: Evaluate the Safety and Efficacy of Intrathecal Injection of RJK002 in Patients With Amyotrophic Lateral Sclerosis [Phase 1]
A Phase 1 clinical trial evaluating the safety and efficacy of intrathecal injection of RJK002 in patients with Amyotrophic Lateral Sclerosi…
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CLINICAL_TRIALS trial_result · 2025-11-18Clinical Trial Update: From Movement Preparation to Gait Execution in ALS
The trial update indicates that the study on movement preparation to gait execution in amyotrophic lateral sclerosis has completed.
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CLINICAL_TRIALS research · 2025-11-18Clinical Trial Update: Brain Excitability and Connectivity in Sensory-motor Pathways in ALS [NA]
A completed clinical trial in France evaluated brain excitability and connectivity in sensory-motor pathways in amyotrophic lateral sclerosi…
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CLINICAL_TRIALS research · 2025-11-18Clinical Trial Update: Perception of Unpleasant Sensations During Study Procedures in ALS Patients
This clinical trial update reports the completion of a study in amyotrophic lateral sclerosis. It evaluates ALS patients' perceptions of unp…
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CLINICAL_TRIALS trial_result · 2025-11-17Clinical Trial Update: Immuno-modulation in Amyotrophic Lateral Sclerosis- a Phase II Study of Safety and Activity of Low Dose Interleukin-2 [Phase 2]
Phase II trial assessing safety and activity of low-dose Interleukin-2 in amyotrophic lateral sclerosis has completed.
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CLINICAL_TRIALS research · 2025-11-17Clinical Trial Update: Resiliency Intervention for Patients With ALS and Their Care-Partners [NA]
This clinical trial update describes a resiliency intervention for people with amyotrophic lateral sclerosis and their care partners, curren…
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CLINICAL_TRIALS trial_result · 2025-11-14Clinical Trial Update: HEALEY ALS Platform Trial - Regimen F ABBV-CLS-7262 [Phase 2, Phase 3]
The HEALEY ALS Platform Trial's Regimen F with ABBV-CLS-7262 completed Phase 2 and Phase 3 cohorts, with trial results posted on 2025-11-14.
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CLINICAL_TRIALS research · 2025-11-14Clinical Trial Update: ALS/MND Natural History Study Data Repository
Clinical trial update announcing a natural history data repository study for ALS and related motor neuron diseases, with recruitment ongoing…
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CLINICAL_TRIALS trial_result · 2025-11-10Clinical Trial Update: Effects of Remote Ischemic Conditioning on Hand Use in Individuals With SCI and ALS [NA]
Results from a study on remote ischemic conditioning and hand use in individuals with spinal cord injury and amyotrophic lateral sclerosis h…
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CLINICAL_TRIALS research · 2025-11-04Clinical Trial Update: VOICE: An Early Feasibility Study of a Precise Robotically Implanted Brain-Computer Interface for Communication Restoration [NA]
This is an update on Neuralink's VOICE study, an early feasibility trial of a robotically implanted brain-computer interface designed to res…
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CLINICAL_TRIALS research · 2025-10-30Clinical Trial Update: Trial of Oral Digoxin in Individuals With Amyotrophic Lateral Sclerosis (ALS) [Phase 2]
A Phase 2 trial evaluating oral digoxin in people with amyotrophic lateral sclerosis is currently active but not recruiting. The study is sp…
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CLINICAL_TRIALS research · 2025-10-28Clinical Trial Update: A Study of Ranolazine in ALS [Phase 2]
A Phase 2 clinical trial evaluating ranolazine in amyotrophic lateral sclerosis is currently recruiting.
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CLINICAL_TRIALS research · 2025-10-22Clinical Trial Update: Safety, Tolerability, and Exploratory Efficacy Study of Intrathecally Administered Gene Therapy AMT-162 in Adult Participants With SOD1 Amyotrophic Lateral Sclerosis (SOD1-ALS) [Phase 1, Phase 2]
A Phase 1/2 clinical trial update describing the safety, tolerability, and exploratory efficacy of intrathecally delivered AMT-162 gene ther…
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CLINICAL_TRIALS research · 2025-10-20Clinical Trial Update: TRIAL READY (Clinical Trial Readiness)
The TRIAL READY clinical trial update (NCT03912987) shows the study is active but not recruiting, with conditions including amyotrophic late…
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CLINICAL_TRIALS trial_result · 2025-10-10Clinical Trial Update: Treatment Combining Riluzole and IFB-088 in Bulbar Amyotrophic Lateral Sclerosis (TRIALS Protocol) [Phase 2]
A Phase 2 trial evaluating the combination of riluzole and IFB-088 for bulbar amyotrophic lateral sclerosis has completed with results poste…
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CLINICAL_TRIALS trial_result · 2025-10-09Clinical Trial Update: A Study to Assess the Safety, Tolerability, and Effect on Disease Progression of BIIB105 in Participants With Amyotrophic Lateral Sclerosis (ALS) and Participants With the ALS Ataxin-2 (ATXN2) Genetic Mutation [Phase 1, Phase 2]
A Phase 1/2 study evaluating BIIB105 in amyotrophic lateral sclerosis (including participants with the ATXN2 genetic mutation) was terminate…
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CLINICAL_TRIALS trial_result · 2025-10-08Clinical Trial Update: Impact of the Combined Treatment of Liposomed Polyphenols With G04CB02 on the ALS Patients [Phase 2]
A Phase 2 clinical trial evaluating the combined treatment of Liposomed Polyphenols with G04CB02 in amyotrophic lateral sclerosis has comple…
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CLINICAL_TRIALS research · 2025-10-08Clinical Trial Update: Identification of Early Markers for ALS [NA]
A France-sponsored clinical trial is currently recruiting to identify early markers for amyotrophic lateral sclerosis.
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CLINICAL_TRIALS research · 2025-10-08Clinical Trial Update: Remote Speech and Swallowing Assessment in ALS
Clinical trial update for a study evaluating remote speech and swallowing assessment in amyotrophic lateral sclerosis; the trial is currentl…