Amyotrophic Lateral Sclerosis
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CLINICAL_TRIALS research · 2025-03-19Clinical Trial Update: A Trial of Nicotinamide/Pterostilbene Supplement in ALS: The NO-ALS Extension Study [NA]
This entry reports the NO-ALS extension study evaluating a nicotinamide/pterostilbene supplement for amyotrophic lateral sclerosis; the tria…
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CLINICAL_TRIALS trial_result · 2025-03-18Clinical Trial Update: Study to Investigate the Efficacy and Safety of FAB122 (Daily Oral Edaravone) in Patients With Amyotrophic Lateral Sclerosis [Phase 3]
Phase 3 trial results for FAB122, a daily oral edaravone formulation, in amyotrophic lateral sclerosis have been posted.
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CLINICAL_TRIALS research · 2025-03-18Clinical Trial Update: Discovery and Validation of Protein Structural Complexes in Circulating Biofluids As Novel Biomarkers for Early Diagnosis, Prognosis and Therapeutic Management of Patients Affected by Neurodegenerative Disorders
This clinical trial seeks to discover and validate protein structural complexes in circulating biofluids as biomarkers for early diagnosis, …
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CLINICAL_TRIALS research · 2025-03-17Clinical Trial Update: A Study to Evaluate the Tolerability, Safety and Efficacy of VGN-R13 in Patients with ALS [EARLY_Phase 1]
A clinical trial update announcing an EARLY_PHASE1 study to evaluate tolerability, safety and efficacy of VGN-R13 in patients with Amyotroph…
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CLINICAL_TRIALS research · 2025-03-14Clinical Trial Update: Hypercaloric PEG Nutrition in ALS to Sustain Energy Homeostasis [NA]
Ongoing clinical trial at the University of Ulm evaluating a hypercaloric PEG-based nutrition approach to sustain energy homeostasis in amyo…
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CLINICAL_TRIALS research · 2025-03-13Clinical Trial Update: An Innovative Method in SAliva Samples for the Early Differential Diagnosis of High-impact NeuroDegenerative Diseases Through Raman Spectroscopy
This clinical trial update describes a saliva-based Raman spectroscopy method to differentiate among several high-impact neurodegenerative d…
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CLINICAL_TRIALS research · 2025-03-13Clinical Trial Update: Research on Wireless Brain Implant System for General Control of External Devices [NA]
A clinical trial from Shanghai StairMed Technology is recruiting to evaluate a wireless brain-implant system that aims to enable control of …
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CLINICAL_TRIALS research · 2025-03-05Clinical Trial Update: Derivation of Induced Pluripotent Stem Cells From an Existing Collection of Human Somatic Cells
The study involves deriving induced pluripotent stem cells from an existing collection of human somatic cells to study amyotrophic lateral s…
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CLINICAL_TRIALS trial_result · 2025-03-04Clinical Trial Update: Study to Investigate the Long-term Safety of FAB122 in Patients With Amyotrophic Lateral Sclerosis [Phase 3]
A Phase 3 study evaluating the long-term safety of FAB122 in amyotrophic lateral sclerosis was terminated, and the results have been posted.
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CLINICAL_TRIALS research · 2025-03-03Clinical Trial Update: NYSCF Scientific Discovery Biobank
Clinical trial entry for the NYSCF Scientific Discovery Biobank (NCT06203106) shows recruiting status and lists indications including amyotr…
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CLINICAL_TRIALS research · 2025-02-28Clinical Trial Update: Transcranial Static Magnetic Stimulation (tSMS) and Potential Theranostic Biomarkers in Amyotrophic Lateral Sclerosis. [NA]
A registered clinical trial investigating transcranial static magnetic stimulation and potential theranostic biomarkers for amyotrophic late…
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CLINICAL_TRIALS research · 2025-02-28Clinical Trial Update: Novel MRI Biomarkers for Monitoring Disease Progression in ALS
University of Alberta is recruiting for a clinical study evaluating novel MRI biomarkers to monitor disease progression in amyotrophic later…
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CLINICAL_TRIALS research · 2025-02-11Clinical Trial Update: Measurement and Impact of Physical Impairment in Amyotrophic Lateral Sclerosis: Use of Digital Technologies - A Precision ALS Project
This clinical trial update describes the Precision ALS project, which uses digital technologies to measure physical impairment in amyotrophi…
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CLINICAL_TRIALS research · 2025-02-11Clinical Trial Update: Individualized Functional Imaging-Guided Repetitive Transcranial Magnetic Stimulation (rTMS) for Treating Postural Gait Disorders in Patients with Amyotrophic Lateral Sclerosis (ALS): a Randomized, Crossover, Controlled, Double-Blind Clinical Study [EARLY_Phase 1]
A Phase 1 randomized, crossover, double-blind trial is evaluating individualized functional imaging-guided repetitive transcranial magnetic …
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CLINICAL_TRIALS research · 2025-02-05Clinical Trial Update: Augmented Reality BCI Longitudinal Study for Persons With Late Stage ALS [NA]
Cognixion is conducting a longitudinal study of an augmented reality brain-computer interface for people with late-stage amyotrophic lateral…
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CLINICAL_TRIALS trial_result · 2025-02-04Clinical Trial Update: Salivary Biomarker Discovery by Raman Spectroscopy in ALS (SalivALS)
A completed clinical trial investigating salivary biomarkers for amyotrophic lateral sclerosis using Raman spectroscopy (SalivALS), sponsore…
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CLINICAL_TRIALS research · 2025-02-04Clinical Trial Update: Genetics and Environment iNtersection In the ALS-FTD Spectrum: an Italian Twins Cohort studY With a Multi-Omics Approach
This study investigates genetic and environmental factors in the amyotrophic lateral sclerosis and frontotemporal dementia spectrum using a …
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CLINICAL_TRIALS trial_result · 2025-02-03Clinical Trial Update: Extension Study Following the Studies MT-1186-A03 or A04 to Evaluate the Safety of Oral Edaravone in Subjects With ALS [Phase 3]
Extension Phase 3 study evaluating the safety of oral edaravone in subjects with amyotrophic lateral sclerosis. Results were posted on 2025-…
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CLINICAL_TRIALS research · 2025-01-29Clinical Trial Update: Clinical Characteristics, Natural History, Health Care Measures, and Genetic Screening in Patients With ALS
Completed clinical trial update describing clinical characteristics, natural history, health care measures, and genetic screening in patient…
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CLINICAL_TRIALS research · 2025-01-29Clinical Trial Update: Registry Study of Assistive Devices, Medicines and Healthcare Measures in ALS, SMA and Other Neurological Diseases.
A registry study evaluating assistive devices, medicines, and healthcare measures for amyotrophic lateral sclerosis, spinal muscular atrophy…
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CLINICAL_TRIALS research · 2025-01-29Clinical Trial Update: Structural and Functional Networks in ALS: An Insight Into Pseudobulbar Affect [NA]
Clinical trial investigating structural and functional brain networks in amyotrophic lateral sclerosis and pseudobulbar affect. The study is…
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CLINICAL_TRIALS research · 2025-01-28Clinical Trial Update: Safety and Dosimetry of a New Radiotracer to Detect Misfolded SOD1 Associated With Amyotrophic Lateral Sclerosis [Phase 1]
This clinical trial update describes a Phase 1 study evaluating the safety and dosimetry of a new radiotracer intended to detect misfolded S…
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CLINICAL_TRIALS trial_result · 2025-01-28Clinical Trial Update: Tideglusib for the Treatment of Amyotrophic Lateral Sclerosis [Phase 2]
Phase 2 clinical trial update for Tideglusib in amyotrophic lateral sclerosis; the study is not yet recruiting.
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EMA other · 2025-01-22EMA Refused: Masitinib AB Science (Masitinib mesilate) — AB Science
EMA refused to grant marketing authorization for Masitinib mesilate for amyotrophic lateral sclerosis. The application by AB Science was not…
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CLINICAL_TRIALS research · 2025-01-20Clinical Trial Update: Psilocybin Therapy for Psychological Distress in Palliative Patients [Phase 2]
Phase 2 trial update on psilocybin therapy for psychological distress in palliative patients; status is not yet recruiting.