Amyotrophic Lateral Sclerosis
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CLINICAL_TRIALS research · 2025-05-02Clinical Trial Update: Safety, PK and Biodistribution of 18F-OP-801 in Patients With ALS, AD, MS, PD and Healthy Volunteers [Phase 1, Phase 2]
Phase 1/2 clinical trial update assessing safety, pharmacokinetics and biodistribution of the radiotracer 18F-OP-801 in ALS, Parkinson's dis…
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CLINICAL_TRIALS trial_result · 2025-05-01Clinical Trial Update: TJ-68 Clinical Trial in Patients With Amyotrophic Lateral Sclerosis (ALS) and Muscle Cramps [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating TJ-68 in amyotrophic lateral sclerosis and muscle cramps has completed and posted results.
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CLINICAL_TRIALS research · 2025-04-29Clinical Trial Update: COMMAND Early Feasibility Study: Implantable BCI to Control a Digital Device for People With Paralysis [NA]
Update on Synchron Medical's COMMAND Early Feasibility Study, an implantable brain-computer interface to help people with paralysis control …
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CLINICAL_TRIALS trial_result · 2025-04-24Clinical Trial Update: Safety and Tolerance of RAG-17 in Amyotrophic Lateral Sclerosis Patients With SOD1 Gene Mutation [EARLY_Phase 1]
Early-phase results describe the safety and tolerability of RAG-17 in amyotrophic lateral sclerosis patients with SOD1 gene mutation.
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CLINICAL_TRIALS trial_result · 2025-04-24Clinical Trial Update: MERIDIAN: A Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Adults With Amyotrophic Lateral Sclerosis (ALS) [Phase 2]
The Phase 2 Meridian trial evaluating pegcetacoplan in adults with amyotrophic lateral sclerosis was terminated; results have been posted.
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CLINICAL_TRIALS trial_result · 2025-04-20Clinical Trial Update: Tolerability and Efficacy of L-Serine in Patients With Amyotrophic Lateral Sclerosis (ALS) [Phase 2]
Phase 2 trial evaluating tolerability and efficacy of L-Serine in patients with amyotrophic lateral sclerosis; the study was terminated and …
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CLINICAL_TRIALS trial_result · 2025-04-17Clinical Trial Update: Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cell Intrathecal Injection for ALS [Phase 1]
Phase 1 clinical trial update evaluating the safety of intrathecal infusion of cultured allogeneic umbilical cord-derived mesenchymal stem c…
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CLINICAL_TRIALS trial_result · 2025-04-13Clinical Trial Update: Exploratory Evaluation of [11C]MPC6827 [EARLY_Phase 1]
An exploratory early Phase 1 study of the PET tracer [11C]MPC6827 conducted by Columbia University, reporting initial safety/imaging finding…
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CLINICAL_TRIALS research · 2025-04-11Clinical Trial Update: Regulatory T Cells for Amyotrophic Lateral Sclerosis [Phase 1]
A Phase 1 trial by Cellenkos evaluating regulatory T cells for amyotrophic lateral sclerosis is active but not recruiting. It represents an …
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CLINICAL_TRIALS research · 2025-04-09Clinical Trial Update: NuroSleeve Powered Brace & Stimulation System to Restore Arm Function [NA]
Clinical trial update for the NuroSleeve Powered Brace & Stimulation System aimed at restoring arm function in people with various neurologi…
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CLINICAL_TRIALS research · 2025-04-09Clinical Trial Update: The National Amyotrophic Lateral Sclerosis Registry
The National Amyotrophic Lateral Sclerosis Registry is currently recruiting participants, according to ClinicalTrials.gov.
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CLINICAL_TRIALS research · 2025-04-09Clinical Trial Update: A Patient-tailored Genetic/Biomarker/iPSC Combined Approach in ALS - PERMEALS
This clinical trial update describes PERMEALS, a patient-tailored approach combining genetics, biomarkers, and induced pluripotent stem cell…
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CLINICAL_TRIALS trial_result · 2025-04-08Clinical Trial Update: Effects of L-Carnitine in Amyotrophic Lateral Sclerosis Patients With CHCHD10 Mutations [Phase 4]
Phase 4 clinical trial evaluating the effects of L-Carnitine in ALS patients with CHCHD10 mutations has completed.
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CLINICAL_TRIALS research · 2025-04-08Clinical Trial Update: Rho Kinase Inhibitor in Amyotrophic Lateral Sclerosis (REAL) [Phase 2]
Phase 2 clinical trial evaluating a rho kinase inhibitor for amyotrophic lateral sclerosis is underway but currently not recruiting particip…
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CLINICAL_TRIALS research · 2025-04-08Clinical Trial Update: A Study to Evaluate the Safety and Pharmacokinetics of Single and Multiple Doses of Prosetin in Healthy Volunteers and Participants With ALS [Phase 1]
A Phase 1 study is evaluating the safety and pharmacokinetics of single and multiple doses of Prosetin in healthy volunteers and people with…
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CLINICAL_TRIALS other · 2025-04-06Clinical Trial Update: Safety Study of XT-150 in Participants With ALS [Phase 1]
A Phase 1 safety study of XT-150 in participants with amyotrophic lateral sclerosis (ALS) is described. The trial status is not yet recruiti…
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CLINICAL_TRIALS trial_result · 2025-04-02Clinical Trial Update: Intrathecal Autologous Adipose-derived Mesenchymal Stromal Cells for Amyotrophic Lateral Sclerosis (ALS) [Phase 2]
Phase 2 clinical trial evaluating intrathecal autologous adipose-derived mesenchymal stromal cells for ALS has posted results; the trial is …
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CLINICAL_TRIALS trial_result · 2025-03-27Clinical Trial Update: Efficacy and Safety Study of Oral Edaravone Administered in Subjects With ALS [Phase 3]
A Phase 3 clinical trial evaluating the efficacy and safety of oral edaravone in amyotrophic lateral sclerosis has been terminated, with res…
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CLINICAL_TRIALS trial_result · 2025-03-27Clinical Trial Update: Efficacy and Safety Extension Study of Oral Edaravone Administered in Subjects With ALS [Phase 3]
Termination of a Phase 3 extension study of oral edaravone in amyotrophic lateral sclerosis has been announced. Results have been posted.
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CLINICAL_TRIALS trial_result · 2025-03-26Clinical Trial Update: Clinical Trial of Ultra-high Dose Methylcobalamin for ALS [Phase 3]
Phase 3 trial of ultra-high dose methylcobalamin for amyotrophic lateral sclerosis has completed.
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CLINICAL_TRIALS trial_result · 2025-03-25Clinical Trial Update: Early Feasibility Study of the MyoRegulator® for Treatment of ALS [NA]
The early feasibility study of the MyoRegulator for amyotrophic lateral sclerosis has completed.
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CLINICAL_TRIALS research · 2025-03-24Clinical Trial Update: [18F]ACI-19626 PET in TDP-43 Proteinopathies [EARLY_Phase 1]
AC Immune is conducting an early Phase 1 study of the PET tracer [18F]ACI-19626 for imaging TDP-43 proteinopathies, including frontotemporal…
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CLINICAL_TRIALS trial_result · 2025-03-21Clinical Trial Update: Phase 2 Study for SAR443820 in Participants With Amyotrophic Lateral Sclerosis (ALS) [Phase 2]
A Phase 2 study of SAR443820 in amyotrophic lateral sclerosis was terminated, and the trial results have been posted.
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CLINICAL_TRIALS research · 2025-03-20Clinical Trial Update: ALS Research Collaborative
ALS Therapy Development Institute provides a clinical trial update for an ALS research collaboration, and the study is currently recruiting …
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CLINICAL_TRIALS trial_result · 2025-03-19Clinical Trial Update: Study of Safety and Proof of the Mechanism of BLZ945 in ALS Patients [Phase 2]
Novartis' Phase 2 trial of the CSF-1R pathway inhibitor BLZ945 in amyotrophic lateral sclerosis was terminated, with trial results posted on…