Treatment-resistant Depression
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CLINICAL_TRIALS research · 2025-04-25Clinical Trial Update: Does Psilocybin Require Psychedelic Effects to Treat Depression? [Phase 2]
A Phase 2 clinical trial is exploring whether psilocybin's psychedelic effects are necessary to treat treatment-resistant depression, and th…
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CLINICAL_TRIALS research · 2025-04-22Clinical Trial Update: Maintenance rTMS for Depression (Maitr-De) [NA]
Clinical trial update for maintenance rTMS in depression shows a recruiting study for major depressive disorder and treatment-resistant depr…
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CLINICAL_TRIALS trial_result · 2025-04-09Clinical Trial Update: Psilocybin-assisted Interpersonal Therapy for Depression [NA]
A completed clinical trial evaluated psilocybin-assisted interpersonal therapy for treatment-resistant depression.
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CLINICAL_TRIALS research · 2025-04-04Clinical Trial Update: Open Label - Personalized Therapeutic Neuromodulation for Anhedonic Depression [NA]
An open-label clinical trial evaluating personalized therapeutic neuromodulation for treatment-resistant depression, currently active but no…
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FDA approval · 2025-03-24FDA Approved: SPRAVATO — Supplemental Application (Janssen Pharmaceuticals Inc.)
FDA approved Janssen's supplemental application for SPRAVATO (esketamine hydrochloride) under NDA 211243, updating the product's indications…
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CLINICAL_TRIALS research · 2025-03-24Clinical Trial Update: OSU6162 as add-on in SSRI/SNRI-resistant Depression [Phase 2]
A Phase 2 clinical trial evaluating OSU6162 as an add-on therapy for SSRI/SNRI-resistant depression; it is currently recruiting.
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CLINICAL_TRIALS trial_result · 2025-03-24Clinical Trial Update: Pilot Accelerated Theta Burst in Treatment-Resistant Bipolar Depression [NA]
This update reports the completion of a pilot accelerated theta burst stimulation trial in treatment-resistant bipolar depression and notes …
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CLINICAL_TRIALS research · 2025-03-18Clinical Trial Update: Positron Emission Tomography in Transcranial Magnetic Stimulation Intervention for Treatment-resistant Depression [NA]
An ongoing registry study at a Chinese hospital is exploring a PET-guided transcranial magnetic stimulation intervention for treatment-resis…
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CLINICAL_TRIALS research · 2025-03-18Clinical Trial Update: Comparison of Different Acceleration Modes of Transcranial Magnetic Stimulation [NA]
This entry describes a study comparing different acceleration modes of transcranial magnetic stimulation for treatment-resistant depression;…
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CLINICAL_TRIALS trial_result · 2025-03-12Clinical Trial Update: Intensive TMS for Bipolar Depression [NA]
An intensive transcranial magnetic stimulation (TMS) trial for bipolar depression, including treatment-resistant depression, has completed. …
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CLINICAL_TRIALS trial_result · 2025-03-05Clinical Trial Update: Role Of Ketamine in Treatment-Resistant Major Depressive Disorder And Its Effect on Suicidality [NA]
Completed clinical trial evaluating ketamine for treatment-resistant major depressive disorder and its effect on suicidality.
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CLINICAL_TRIALS trial_result · 2025-03-04Clinical Trial Update: A Study of Esketamine Nasal Spray, Administered as Monotherapy, in Adult Participants With Treatment-resistant Depression [Phase 4]
Phase 4 trial evaluating Esketamine nasal spray as monotherapy in adults with treatment-resistant depression has completed, with results pos…
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CLINICAL_TRIALS trial_result · 2025-02-12Clinical Trial Update: Ketogenic Diet for Treatment-Resistant Depression: Dietary Interventions for MEntal Health Study (DIME) [NA]
The DIME study from the University of Oxford evaluating a ketogenic diet for treatment-resistant depression has completed; no efficacy resul…
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CLINICAL_TRIALS research · 2025-01-23Clinical Trial Update: ECT with Ketamine Anesthesia Vs High Intensity Ketamine with ECT Rescue for Treatment-Resistant Depression [Phase 4]
A Phase 4 clinical trial comparing electroconvulsive therapy with ketamine anesthesia versus high-dose ketamine with ECT rescue for treatmen…
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CLINICAL_TRIALS research · 2025-01-20Clinical Trial Update: Personalized DBS Targeting for Treating Depression [EARLY_Phase 1]
An early-phase 1 clinical trial is evaluating personalized deep brain stimulation targeting for treatment-resistant depression and is curren…
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FDA approval · 2025-01-17FDA Approved: SPRAVATO — Supplemental Application (Janssen Pharmaceuticals Inc.)
FDA approved a supplemental application for SPRAVATO (esketamine hydrochloride) from Janssen Pharmaceuticals Inc.
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FDA approval · 2024-12-31FDA Approved: SPRAVATO — Supplemental Application (Janssen Pharmaceuticals Inc.)
FDA approved Janssen's supplemental application for SPRAVATO (esketamine hydrochloride), finalizing a labeling update under NDA 211243.
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CLINICAL_TRIALS research · 2024-12-24Clinical Trial Update: Neurocardiac Predictors of Treatment Response to RTMS in Depression [NA]
This clinical trial update describes a University of British Columbia study investigating neurocardiac predictors of response to repetitive …
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CLINICAL_TRIALS trial_result · 2024-12-20Clinical Trial Update: The RECOVER sUb-study, Which Leverages quaNtitative and Credible Research tOols From Verily, Will providE Assessment measuRes for Depressive Episodes
This clinical trial update reports that the RECOVER sub-study, which used quantitative and credible research tools from Verily to assess dep…
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CLINICAL_TRIALS research · 2024-12-19Clinical Trial Update: The Impact of Working Memory and Reward Markers on DLPFC Activity in Treatment-resistant Depression [NA]
This clinical study from Unity Health Toronto investigates how working memory tasks and reward-related brain markers influence dorsolateral …
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CLINICAL_TRIALS trial_result · 2024-12-12Clinical Trial Update: Long Term Follow-up of Deep Brain Stimulation for Treatment-Resistant Depression [NA]
Long-term follow-up results from a terminated clinical trial evaluating deep brain stimulation for treatment-resistant depression have been …
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CLINICAL_TRIALS trial_result · 2024-12-11Clinical Trial Update: Risk-Targeted Behavioural Activation for the Management of Treatment-Resistant Depression. [NA]
A clinical trial update on risk-targeted behavioural activation for managing treatment-resistant depression. The trial status is completed.
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CLINICAL_TRIALS trial_result · 2024-11-14Clinical Trial Update: Effect of Ketamine on Neurological Activity as Measured by Electroencephalogram (EEG)
This clinical trial evaluated the effect of ketamine on brain activity measured by EEG in individuals with treatment-resistant depression. T…
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CLINICAL_TRIALS trial_result · 2024-11-04Clinical Trial Update: Efficacy of Convulsive Therapies During Continuation [NA]
Completed study evaluating the efficacy of convulsive therapies during the continuation phase for depression, including unipolar, bipolar, a…
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: Efficacy and Safety of MK-1942 When Added to Stable Antidepressant Therapy in Participants With Treatment-Resistant Depression (TRD) (MK-1942-006) [Phase 2]
Phase 2 trial evaluating MK-1942 added to stable antidepressant therapy in treatment-resistant depression was terminated, with results poste…