Treatment-resistant Depression
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CLINICAL_TRIALS research · 2025-07-23Clinical Trial Update: Algorithm Guided Treatment Versus Treatment as Usual (TAU) for Patients With Treatment Resistant Depression [Phase 4]
Phase 4 clinical trial comparing algorithm-guided treatment to treatment as usual for treatment-resistant depression; status is not yet recr…
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CLINICAL_TRIALS trial_result · 2025-07-22Clinical Trial Update: MBCT and Escitalopram for Treatment-Resistant Depression in Older Adults [NA]
The clinical trial evaluating mindfulness-based cognitive therapy (MBCT) plus escitalopram for treatment-resistant depression in older adult…
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CLINICAL_TRIALS trial_result · 2025-07-18Clinical Trial Update: BPL-003 Efficacy and Safety in Treatment Resistant Depression [Phase 2]
Phase 2 trial evaluating BPL-003 for treatment-resistant depression has completed, reporting efficacy and safety findings.
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CLINICAL_TRIALS research · 2025-07-18Clinical Trial Update: Deep Brain Stimulation for Treatment Resistant Depression With the Medtronic Activa PC+S [NA]
Clinical trial update for deep brain stimulation using the Medtronic Activa PC+S in treatment-resistant depression; the study is currently a…
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CLINICAL_TRIALS research · 2025-07-02Clinical Trial Update: Tractography Guided Subcallosal Cingulate Deep Brain Stimulation for Treatment Resistant Depression [NA]
The document describes a recruiting clinical study evaluating tractography-guided subcallosal cingulate deep brain stimulation for treatment…
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CLINICAL_TRIALS trial_result · 2025-06-27Clinical Trial Update: Ketamine Associated ACC GABA and Glutamate Change and Depression Remission: [EARLY_Phase 1]
This early-phase trial reports ketamine-associated changes in ACC GABA and glutamate and notes depression remission. The study targets major…
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CLINICAL_TRIALS approval · 2025-06-22Clinical Trial Update: Pre-Approval Access to Esketamine Nasal Spray for the Treatment of Treatment-Resistant Depression (TRD)
Esketamine nasal spray has been approved for marketing for treatment-resistant depression. This update confirms the regulatory approval stat…
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CLINICAL_TRIALS trial_result · 2025-06-18Clinical Trial Update: Investigate the Clinical Responses of Ethosuximide in Patients With Treatment-Resistant Depression. [EARLY_Phase 1]
This early-phase, completed trial evaluated ethosuximide in patients with treatment-resistant depression. The update notes the study's compl…
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CLINICAL_TRIALS research · 2025-06-17Clinical Trial Update: Accelerated Transcranial Magnetic Stimulation in Treatment-Resistant Depressed Patients [NA]
A clinical trial update from Ataturk University shows an accelerated, sham-controlled bilateral repetitive transcranial magnetic stimulation…
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CLINICAL_TRIALS trial_result · 2025-06-10Clinical Trial Update: Antidepressant Effects of TS-161 in Treatment-Resistant Depression [Phase 2]
The Phase 2 study of TS-161 for treatment-resistant depression was terminated, and trial results have been posted.
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CLINICAL_TRIALS research · 2025-06-03Clinical Trial Update: Comparative Effectiveness Study of Two Forms of Ketamine for Treatment-resistant Depression [Phase 4]
A Phase 4 comparative effectiveness study examining two forms of ketamine for treatment-resistant depression is currently recruiting.
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CLINICAL_TRIALS trial_result · 2025-05-31Clinical Trial Update: A Trial of GH001 in Patients With Treatment-resistant Depression [Phase 2]
GH Research Ireland Limited has completed a Phase 2 trial evaluating GH001 in patients with treatment-resistant depression.
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CLINICAL_TRIALS trial_result · 2025-05-23Clinical Trial Update: Combining rTMS and tDCS in Depression: an Exploratory Clinical Trial [NA]
An exploratory trial evaluating combined rTMS and tDCS for major depressive disorder, including treatment-resistant depression, has been ter…
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CLINICAL_TRIALS research · 2025-05-22Clinical Trial Update: Treatment Resistant Depression and Vagus Nerve Stimulation [NA]
Clinical trial update indicates a study evaluating vagus nerve stimulation for treatment-resistant depression is currently recruiting.
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CLINICAL_TRIALS trial_result · 2025-05-15Clinical Trial Update: A Biomarker-Guided, Randomized, Placebo-Controlled Efficacy and Safety Study of Liafensine in Patients With TRD [Phase 2]
A biomarker-guided, randomized, placebo-controlled Phase 2 trial evaluating Liafensine for treatment-resistant depression has completed, wit…
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FDA approval · 2025-05-15FDA Approved: SPRAVATO — Supplemental Application (Janssen Pharmaceuticals Inc.)
The FDA approved a supplemental application for Spravato (esketamine hydrochloride) submitted by Janssen Pharmaceuticals. The action updates…
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CLINICAL_TRIALS research · 2025-05-13Clinical Trial Update: Adjuvant Accelerated piTBS for Reducing Suicidal Ideation in TRD Patients [NA]
Clinical trial update on an adjuvant accelerated piTBS approach to reduce suicidal ideation in patients with treatment-resistant major depre…
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CLINICAL_TRIALS research · 2025-05-07Clinical Trial Update: Maintenance TMS in Treatment Resistant Depression [NA]
A clinical trial is currently recruiting to evaluate maintenance transcranial magnetic stimulation for treatment-resistant depression.
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CLINICAL_TRIALS research · 2025-05-04Clinical Trial Update: Imaging the Effects of Serotonin 2A Receptor Modulation on Synaptic Density in Treatment-resistant Depression (SYNVEST) [Phase 2]
Phase 2 clinical trial investigating imaging the effects of a serotonin 2A receptor modulator on synaptic density in treatment-resistant dep…
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CLINICAL_TRIALS research · 2025-05-01Clinical Trial Update: Deciphering Principles of Network Dynamics Underlying Depression Symptom Severity From Multi-day Intracranial Recordings in Patients With Major Depression
This completed clinical trial studies how brain network dynamics, measured via multi-day intracranial recordings, relate to depression sympt…
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CLINICAL_TRIALS research · 2025-04-30Clinical Trial Update: Physical Activity Program for TRD [NA]
Clinical trial investigating a physical activity program for treatment-resistant depression and major depressive disorder; currently recruit…
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FDA approval · 2025-04-28FDA Approved: SPRAVATO — Supplemental Application (Janssen Pharmaceuticals Inc.)
FDA approves a supplemental application for SPRAVATO (esketamine hydrochloride) submitted by Janssen Pharmaceuticals Inc.
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CLINICAL_TRIALS trial_result · 2025-04-27Clinical Trial Update: Treatment-Resistant Depression Cohort in Europe
A European treatment-resistant depression cohort trial sponsored by Janssen-Cilag Ltd has been completed, per ClinicalTrials.gov update.
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CLINICAL_TRIALS trial_result · 2025-04-27Clinical Trial Update: Treatment Resistant Depression in America Latina
This clinical trial update reports that a Janssen-sponsored study on treatment-resistant depression conducted in Latin America has reached c…
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CLINICAL_TRIALS trial_result · 2025-04-27Clinical Trial Update: An Epidemiology Study of Treatment Resistant Depression in the United States (US)
This is a completed epidemiology study in the United States examining treatment-resistant depression, sponsored by Janssen Research & Develo…