Treatment-resistant Depression
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CLINICAL_TRIALS research · 2024-09-19Clinical Trial Update: Psilocybin for Hospitalized Patients with Treatment-resistant Depression [Phase 2]
A Phase 2 clinical trial tests psilocybin in hospitalized patients with treatment-resistant depression. The study is currently recruiting.
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: Stepped Care AiTBS 2 Depression Study (Ghent) [NA]
Clinical trial update for the Stepped Care AiTBS 2 Depression Study in Ghent; the study involving major depressive disorder and treatment-re…
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CLINICAL_TRIALS research · 2024-08-09Clinical Trial Update: An Open Label Study of the Safety and Efficacy of Psilocybin in Participants With Treatment-Resistant Depression (P-TRD) [Phase 2]
An open-label Phase 2 study evaluating the safety and efficacy of psilocybin in participants with treatment-resistant depression; the trial …
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CLINICAL_TRIALS research · 2024-08-07Clinical Trial Update: Identifying Local Field Potential Biomarkers for Treatment-Resistant Major Depression With Deep Brain Stimulation [NA]
A clinical trial at West China Hospital is investigating local field potential biomarkers for treatment-resistant major depression using dee…
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CLINICAL_TRIALS research · 2024-08-07Clinical Trial Update: Efficacy of Deep Brain Stimulation(DBS) for Treatment-Resistant Depression(TRD) [NA]
A clinical trial update indicates a study evaluating the efficacy of deep brain stimulation for treatment-resistant depression, currently no…
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CLINICAL_TRIALS trial_result · 2024-08-06Clinical Trial Update: Computational Psychiatric Approach to Depression
A Wake Forest University Health Sciences study on a computational psychiatric approach to depression has completed, covering depression and …
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CLINICAL_TRIALS research · 2024-07-10Clinical Trial Update: IV Ketamine vs. IN Esketamine for MDD TRD
A clinical trial comparing intravenous ketamine with intranasal esketamine for treatment-resistant depression is currently recruiting.
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CLINICAL_TRIALS trial_result · 2024-06-04Clinical Trial Update: A Randomized, Placebo-Controlled, Double-Blind Study to Assess Safety and Efficacy of PCN-101 in TRD [Phase 2]
This document reports the results of a Phase 2 randomized, double-blind, placebo-controlled trial evaluating PCN-101 for treatment-resistant…
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CLINICAL_TRIALS trial_result · 2024-05-29Clinical Trial Update: Observation of Safety and Tolerability Within 1 Year of the Use of R-ketamine / Placebo in Drug-resistant Depression
A completed clinical trial update reporting safety and tolerability observations over one year after treatment with R-ketamine versus placeb…
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CLINICAL_TRIALS research · 2024-05-21Clinical Trial Update: Glutamate Emotion Memory Study [NA]
Ongoing clinical trial at University of Oxford investigating glutamate-related treatment for treatment-resistant depression and depression; …
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CLINICAL_TRIALS trial_result · 2024-05-08Clinical Trial Update: Sustained Mood Improvement With Laughing Gas Exposure: A Randomized Controlled Pilot Trial [Phase 4]
Phase 4 randomized controlled pilot trial evaluating nitrous oxide exposure for sustained mood improvement in treatment-resistant depression…
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CLINICAL_TRIALS research · 2024-05-07Clinical Trial Update: Neural and Antidepressant Effects of Propofol [Phase 2, Phase 3]
This is a clinical trial update on Phase 2 and Phase 3 studies evaluating the neural and antidepressant effects of propofol in treatment-res…
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CLINICAL_TRIALS research · 2024-05-07Clinical Trial Update: pBFS-guided rTMS Over DMPFC for Treatment-Resistant Depression [NA]
A clinical study is evaluating pBFS-guided repetitive transcranial magnetic stimulation over the dorsomedial prefrontal cortex for treatment…
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CLINICAL_TRIALS withdrawal · 2024-05-03Clinical Trial Update: First-In-Human (FIH), Single Ascending Dose (SAD) Study of FluoroEthylNorMemantine (FENM) [Phase 1]
The first-in-human single ascending dose study of FluoroEthylNorMemantine (FENM) by ReST Therapeutics has been withdrawn; the listed conditi…
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CLINICAL_TRIALS research · 2024-04-30Clinical Trial Update: Home-based Transcranial Direct Current Stimulation for Treatment Resistant Depression [NA]
A clinical trial is evaluating home-based transcranial direct current stimulation for treatment-resistant depression and is currently recrui…
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CLINICAL_TRIALS research · 2024-04-30Clinical Trial Update: Accelerated Intermittent Theta-Burst Stimulation (aiTBS) in Treatment-Resistant Depression of Bipolar II Disorder [NA]
Clinical trial evaluating accelerated intermittent theta-burst stimulation as a treatment for treatment-resistant depression in Bipolar II d…
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CLINICAL_TRIALS trial_result · 2024-02-09Clinical Trial Update: Stellate Ganglion Block for Major Depressive Disorder. [Phase 4]
Phase 4 clinical trial update on stellate ganglion block as treatment for treatment-resistant depression and major depressive disorder has c…
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CLINICAL_TRIALS trial_result · 2024-02-09Clinical Trial Update: Predictors of Intravenous Ketamine Response in TRD [Phase 3]
A Phase 3 trial update investigating predictors of intravenous ketamine response in treatment-resistant depression and major depressive diso…
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CLINICAL_TRIALS trial_result · 2024-01-31Clinical Trial Update: Salicylic Augmentation in Depression [Phase 2]
Phase 2 trial investigating salicylic augmentation in depression was terminated; results posted in 2024.
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CLINICAL_TRIALS trial_result · 2023-12-05Clinical Trial Update: Deep Brain Stimulation for Treatment Resistant Depression [Phase 1, Phase 2]
Clinical trial update for deep brain stimulation as a treatment for treatment-resistant depression (Phase 1/Phase 2).
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CLINICAL_TRIALS trial_result · 2023-11-28Clinical Trial Update: The Safety and Efficacy of Fecal Microbiota Transplantation in a Population With Major Depressive Disorder [Phase 2, Phase 3]
Phase 2/3 clinical trial investigating the safety and efficacy of fecal microbiota transplantation in individuals with major depressive diso…
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CLINICAL_TRIALS trial_result · 2023-11-09Clinical Trial Update: The Safety and Efficacy Of Psilocybin as an Adjunctive Therapy in Participants With Treatment Resistant Depression [Phase 2]
Phase 2 trial results assessing psilocybin as an adjunctive therapy for treatment-resistant depression have been completed with posted resul…
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CLINICAL_TRIALS trial_result · 2023-08-22Clinical Trial Update: Comparison of Antidepressant Augmentation With Amantadine vs Pramipexole vs Quetiapine in Treatment Resistant Depression [Phase 4]
Phase 4 trial comparing augmentation strategies (amantadine, pramipexole, and quetiapine) for treatment-resistant depression.
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CLINICAL_TRIALS trial_result · 2023-08-15Clinical Trial Update: Clinical Study of GH001 in Depression [Phase 1, Phase 2]
Phase 1/2 clinical study of GH001 for treatment-resistant depression and major depressive disorder has completed.
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CLINICAL_TRIALS trial_result · 2023-08-09Clinical Trial Update: ELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD) [Phase 2, Phase 3]
A completed phase 2/3 trial comparing electroconvulsive therapy (ECT) to ketamine for treatment-resistant depression, with results posted in…