Treatment-resistant Depression
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: Ketamine-Assisted Psychotherapy for Treatment-Resistant Depression [Phase 2]
A Phase 2 clinical trial investigating ketamine-assisted psychotherapy for treatment-resistant depression, including chronic pain as a condi…
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: Dasatinib Plus Quercetin for Accelerated Aging in Mental Disorders [Phase 2]
Phase 2 clinical trial update evaluating dasatinib plus quercetin for accelerated aging in schizophrenia and treatment-resistant depression;…
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: Transcranial Photobiomodulation (tPBM) for Somatic Symptoms in Treatment-Resistant Depression [NA]
The document reports ongoing recruitment for a clinical trial using transcranial photobiomodulation to address somatic symptoms in treatment…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Improving Brain Stimulation Through Imaging
Clinical trial update describing research on improving brain stimulation through imaging for depression. The study includes treatment-resist…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response [Phase 2]
Phase 2 ACP-211 monotherapy for major depressive disorder is currently recruiting, including treatment-resistant cases. The sponsor is ACADI…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression [Phase 2]
Phase 2 clinical trial update investigating the antidepressant effects of 2R,6R-hydroxynorketamine (HNK) as a glutamate-release enhancer for…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND) [NA]
A clinical trial update indicating that Abbott Medical Devices is recruiting for TRANSCEND, a deep brain stimulation study targeting treatme…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: Early Brainwave Biomarkers for Personalized Neuromodulation in Treatment-resistant Depression [NA]
A clinical trial registry entry describing research on early brainwave biomarkers to guide personalized neuromodulation for treatment-resist…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Belief Updating in Treatment Resistant Depression
An ongoing clinical trial (NCT05577247) sponsored by Assistance Publique - Hôpitaux de Paris is investigating belief updating in individuals…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: rTMS With and Without Text4Support for the Treatment of Resistant Depression. [NA]
A clinical trial update indicates recruiting for a study of repetitive transcranial magnetic stimulation (rTMS) with and without Text4Suppor…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: A Study of Esketamine Nasal Spray in Korean Participants With Treatment-resistant Depression [Phase 4]
Clinical trial update for Esketamine Nasal Spray in Korean participants with treatment-resistant depression, in Phase 4 and currently recrui…
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CLINICAL_TRIALS research · 2026-04-06Clinical Trial Update: Mindfulness Engaged Neurostimulation for Depression (MEND II) [Phase 2]
Phase 2 clinical trial evaluating Mindfulness Engaged Neurostimulation for Depression is not yet recruiting, studying treatment options for …
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: Psilocybin Assisted Psychotherapy for Treatment Resistant Depression and Co-occurring Substance Use Disorder [Phase 1, Phase 2]
This is a clinical trial update describing a psilocybin-assisted psychotherapy study for treatment-resistant depression with co-occurring su…
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CLINICAL_TRIALS research · 2026-03-23Clinical Trial Update: Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant Depression [Phase 1]
This Phase 1 trial investigates whether gamma oscillations can predict response to ketamine therapy in treatment-resistant depression. The s…
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CLINICAL_TRIALS research · 2026-03-20Clinical Trial Update: Psilocybin for Treatment-Resistant Depression in Autism [Phase 1]
Phase 1 clinical trial investigating psilocybin for treatment-resistant depression in individuals with autism spectrum disorder is currently…
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CLINICAL_TRIALS research · 2026-03-18Clinical Trial Update: Evaluating the Role of Psilocybin Monitors in Psilocybin Therapy for Treatment Resistant Depression [Phase 2]
A Phase 2 clinical trial update evaluating the role of psilocybin monitors in psilocybin-assisted therapy for treatment-resistant depression…
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CLINICAL_TRIALS research · 2026-03-16Clinical Trial Update: ipRGC as a Potential Biomarker for Predicting Transcranial Magnetic Stimulation Treatment Response in Major Depressive Disorder [NA]
A clinical trial is evaluating intrinsically photosensitive retinal ganglion cells (ipRGCs) as a biomarker to predict response to transcrani…
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CLINICAL_TRIALS research · 2026-03-16Clinical Trial Update: InTRavenous kEtAmine and immerSive virtUal Reality to Treat dEpression [Phase 3]
Phase 3 trial update for intravenous ketamine combined with immersive virtual reality to treat treatment-resistant depression; the study is …
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CLINICAL_TRIALS research · 2026-03-16Clinical Trial Update: Characterizing Dopamine Receptor Binding in Treatment Resistant Depression
A clinical trial in recruitment to characterize dopamine receptor binding in patients with treatment-resistant depression.
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: Disruptions of Brain Networks and Sleep by Electroconvulsive Therapy
A clinical trial is examining how electroconvulsive therapy affects brain networks and sleep in individuals with treatment-resistant depress…
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CLINICAL_TRIALS research · 2026-03-03Clinical Trial Update: 40 Hz Light Neurostimulation for Patients With Depression (FELIX) [NA]
Ongoing clinical trial evaluating 40 Hz light neurostimulation for adults with major depressive disorder and treatment-resistant depression.…
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CLINICAL_TRIALS research · 2026-03-03Clinical Trial Update: University of Iowa Interventional Psychiatry Service Patient Registry
This clinical trial registry entry from the University of Iowa Interventional Psychiatry Service is recruiting participants for a patient re…
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CLINICAL_TRIALS research · 2026-03-02Clinical Trial Update: Ultrasound Neuromodulation of Circuits and Negative Valence Systems in Treatment-Resistant Depression [NA]
A clinical trial from Laureate Institute for Brain Research is investigating ultrasound neuromodulation targeting brain circuits and negativ…
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: Virtual Reality-Based Mindfulness as an Adjunct to Treatment as Usual in Treatment-Resistant Depression [NA]
Clinical trial evaluating virtual reality-based mindfulness as an adjunct to treatment as usual for treatment-resistant depression. The stud…
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CLINICAL_TRIALS research · 2026-02-25Clinical Trial Update: Biomarker-guided rTMS for Treatment Resistant Depression [Phase 3]
Phase 3 clinical trial investigating biomarker-guided repetitive transcranial magnetic stimulation for treatment-resistant depression is cur…