Treatment-resistant Depression
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CLINICAL_TRIALS trial_result · 2025-11-24Clinical Trial Update: Nitrous Oxide for Late-Life Depression - PROTO-BRAIN [NA]
The PROTO-BRAIN study evaluating nitrous oxide for late-life depression and treatment-resistant depression has completed.
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CLINICAL_TRIALS trial_result · 2025-11-20Clinical Trial Update: Dose-Optimized and Spaced Transcranial Direct Current Stimulation for Treatment-Resistant Depression [NA]
A completed clinical trial evaluating dose-optimized and spaced transcranial direct current stimulation for treatment-resistant depression a…
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CLINICAL_TRIALS research · 2025-11-19Clinical Trial Update: Psilocybin Microdosing With Psychotherapy for Treatment-Resistant Depression [Phase 2]
Phase 2 trial evaluating psilocybin microdosing with psychotherapy for treatment-resistant depression; recruitment is ongoing at Beersheva M…
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CLINICAL_TRIALS research · 2025-11-12Clinical Trial Update: A Randomized, Double-Blind Controlled Comparison of NRX-101 vs. Placebo for Adults Being Treated With Transcranial Magnetic Stimulation for Treatment Resistant Depression [Phase 2, Phase 3]
Clinical trial update describing a randomized, double-blind comparison of NRX-101 vs placebo for adults with treatment-resistant depression,…
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CLINICAL_TRIALS research · 2025-11-10Clinical Trial Update: Psilocybin Intervention for Veterans Overcoming Treatment-Resistant Depression [Phase 3]
Phase 3 clinical trial evaluating psilocybin for treatment-resistant major depression in veterans is not yet recruiting.
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CLINICAL_TRIALS trial_result · 2025-11-06Clinical Trial Update: Transcranial Direct Current Stimulation (tDCS) as an Adjunctive Treatment for Treatment Resistant Depression (TRD) [NA]
This clinical trial update indicates a Mayo Clinic study evaluating transcranial direct current stimulation as an adjunctive treatment for t…
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CLINICAL_TRIALS research · 2025-11-05Clinical Trial Update: Cortical Inhibition as a Biomarker of Response in a Comparison of Bilateral Versus Unilateral Accelerated Theta Burst Stimulation for Suicidal Ideation in Treatment-Resistant Depression -COMBAT-SI [NA]
A clinical trial evaluating cortical inhibition as a biomarker of response in a comparison of bilateral versus unilateral accelerated theta …
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CLINICAL_TRIALS research · 2025-10-27Clinical Trial Update: Mapping and Modulating the Spatiotemporal Dynamics of Socio-Affective Processing [NA]
A Baylor College of Medicine clinical trial is recruiting to map and modulate the spatiotemporal dynamics of socio-affective processing in t…
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CLINICAL_TRIALS research · 2025-10-14Clinical Trial Update: Intravenous Ketamine for Treatment-Resistant Depression [Phase 2]
Phase 2 clinical trial evaluating intravenous ketamine for treatment-resistant depression is currently recruiting.
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FDA approval · 2025-10-09FDA Approved: SPRAVATO — Supplemental Application (Janssen Pharmaceuticals Inc.)
The FDA approved a supplemental application for SPRAVATO (esketamine hydrochloride) filed by Janssen Pharmaceuticals Inc.
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CLINICAL_TRIALS research · 2025-10-07Clinical Trial Update: Efficacy of Psilocybin and Trazodone Combination in Treatment-resistant Depression: a Randomized Controlled Proof-of-concept Study (PSILOTRAZ) [Phase 2]
A Phase 2 randomized proof-of-concept study evaluating the efficacy of a psilocybin and trazodone combination for treatment-resistant depres…
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CLINICAL_TRIALS research · 2025-10-03Clinical Trial Update: Mental Health Mission Mood Disorder Cohort Study
Clinical trial update from the University of Oxford for a mood disorder cohort study. The trial is currently not recruiting and covers major…
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CLINICAL_TRIALS trial_result · 2025-09-29Clinical Trial Update: Development of Neuro-Navigated Transcranial Magnetic Stimulation (TMS) Using MRI
This update reports the completion of a clinical trial evaluating MRI-guided neuro-navigated Transcranial Magnetic Stimulation for treatment…
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CLINICAL_TRIALS trial_result · 2025-09-29Clinical Trial Update: Virtual Neuro-Navigation System for Personalized Community Based TMS [NA]
This update reports on a completed clinical trial evaluating a virtual neuro-navigation system to guide personalized community-based transcr…
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CLINICAL_TRIALS research · 2025-09-29Clinical Trial Update: rTMS to Target Neural Connectivity and Rumination in Treatment-Resistant Depression [NA]
A clinical trial update describes an NCT06511544 study evaluating repetitive transcranial magnetic stimulation (rTMS) to improve neural conn…
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CLINICAL_TRIALS research · 2025-09-26Clinical Trial Update: The Effect of a Six Week Intensified Pharmacological Treatment for Major Depressive Disorder Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment. [Phase 3]
A Phase 3 clinical trial is examining whether a six-week intensified pharmacological treatment improves outcomes in adults with major depres…
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CLINICAL_TRIALS trial_result · 2025-09-24Clinical Trial Update: Personalized rTMS for Resistant Depression [NA]
A clinical trial update notes that a study of personalized repetitive transcranial magnetic stimulation for treatment-resistant depression h…
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CLINICAL_TRIALS research · 2025-09-23Clinical Trial Update: Randomized Controlled Trial Testing the Efficacy of Transcranial Magnetic Stimulation by Accelerated & High-dose Theta-burst, Functional Imaging Guided, in the Treatment of Depression in Elderly Subjects With Cognitive Impairment [NA]
A randomized controlled trial is testing accelerated, high-dose theta-burst transcranial magnetic stimulation guided by functional imaging f…
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CLINICAL_TRIALS trial_result · 2025-09-05Clinical Trial Update: Low-dose Ketamine Infusion Among Adolescents With Treatment-resistant Depression [Phase 4]
A Phase 4 trial evaluated low-dose ketamine infusions in adolescents with treatment-resistant depression and major depressive disorder. The …
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CLINICAL_TRIALS trial_result · 2025-08-20Clinical Trial Update: Effect of Psilocybin on the Positive Valence System in Treatment-resistant Depression [NA]
A completed clinical trial evaluating the effect of psilocybin on the positive valence system in treatment-resistant depression.
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CLINICAL_TRIALS trial_result · 2025-08-15Clinical Trial Update: Confirmatory Efficacy and Safety Trial of Magnetic Seizure Therapy for Depression [NA]
A confirmatory efficacy and safety trial of Magnetic Seizure Therapy for depression has completed.
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CLINICAL_TRIALS research · 2025-08-11Clinical Trial Update: Focused Ultrasound Neuromodulation in Patients With Treatment-Resistant Depression [NA]
A clinical trial is evaluating focused ultrasound neuromodulation as a treatment for treatment-resistant depression and is currently recruit…
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CLINICAL_TRIALS trial_result · 2025-08-05Clinical Trial Update: 2-Year Study of Vagus Nerve Stimulation for Higher-Grade Treatment-Resistant Depression: Clinical Outcomes and Policy Recommendation
A two-year study evaluating vagus nerve stimulation for higher-grade treatment-resistant depression reports clinical outcomes and includes a…
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FDA approval · 2025-07-31FDA Approved: SPRAVATO — Supplemental Application (Janssen Pharmaceuticals Inc.)
The FDA approved Janssen's supplemental application for SPRAVATO (esketamine hydrochloride), updating its labeling to reflect the approved s…
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CLINICAL_TRIALS research · 2025-07-29Clinical Trial Update: Ketamine Augmentation of ECT in Treatment-Resistant Depression [Phase 3]
Phase 3 study evaluating ketamine augmentation of electroconvulsive therapy for treatment-resistant major depressive disorder is currently r…