Treatment-resistant Depression
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-01-27Clinical Trial Update: Esketamine With or Without Integration Therapy for Treatment-Resistant Depression [Phase 4]
A Phase 4 clinical trial is evaluating esketamine with or without integration therapy for treatment-resistant depression and is currently re…
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CLINICAL_TRIALS research · 2026-01-26Clinical Trial Update: A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression [NA]
A prospective, multi-center randomized blinded trial evaluating the safety and effectiveness of the VNS Therapy System as adjunctive therapy…
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CLINICAL_TRIALS research · 2026-01-22Clinical Trial Update: COpenhagen Magnetic Personalized Accelerated Brain Circuit Therapy for Treatment Resistant Depression [NA]
A clinical trial update for Copenhagen Magnetic Personalized Accelerated Brain Circuit Therapy for treating treatment-resistant depression, …
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CLINICAL_TRIALS withdrawal · 2026-01-21Clinical Trial Update: NESBID: Neuro-Stimulation of the Brain in Depression [NA]
NESBID, a trial of neuro-stimulation for depression, has been withdrawn. The study involved transcranial direct current stimulation for majo…
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CLINICAL_TRIALS research · 2026-01-21Clinical Trial Update: Psilocybin for Treatment-Resistant Depression [Phase 2]
Phase 2 clinical trial update on psilocybin for treatment-resistant major depressive disorder; the study is currently active but not recruit…
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CLINICAL_TRIALS research · 2026-01-20Clinical Trial Update: DBS for Depression [Phase 1]
A Phase 1 clinical trial sponsored by Northwell Health evaluating deep brain stimulation for treatment-resistant depression is currently rec…
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CLINICAL_TRIALS research · 2026-01-16Clinical Trial Update: Compressed Intermittent Theta Burst Stimulation [NA]
University of Pennsylvania is conducting a clinical trial on compressed intermittent theta burst stimulation for treatment-resistant depress…
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CLINICAL_TRIALS trial_result · 2026-01-12Clinical Trial Update: Efficacy, Safety, and Tolerability of Two Administrations of COMP360 in Participants With TRD [Phase 3]
Phase 3 trial update evaluating two administrations of COMP360 (psilocybin) for treatment-resistant depression, focusing on efficacy, safety…
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CLINICAL_TRIALS withdrawal · 2026-01-12Clinical Trial Update: Low-Intensity Focused Ultrasound for Treatment-Resistant Depression [NA]
Trial evaluating low-intensity focused ultrasound for treatment-resistant depression has been suspended.
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CLINICAL_TRIALS research · 2026-01-12Clinical Trial Update: Antidepressant Effects of Nitrous Oxide [Phase 2]
Phase 2 clinical trial evaluating the antidepressant effects of nitrous oxide in major depressive disorder and treatment-resistant depressio…
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CLINICAL_TRIALS research · 2026-01-09Clinical Trial Update: Neuronavigated aiTBS for TRD [NA]
This clinical trial entry describes neuronavigated accelerated intermittent theta-burst stimulation (aiTBS) for treatment-resistant depressi…
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CLINICAL_TRIALS research · 2026-01-07Clinical Trial Update: Electroconvulsive Therapy Augmented With Transcranial Magnetic Stimulation for Treatment Resistant Depression [NA]
A clinical trial evaluating whether adding transcranial magnetic stimulation to electroconvulsive therapy for treatment-resistant depression…
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CLINICAL_TRIALS trial_result · 2025-12-31Clinical Trial Update: Multiple Ascending Dose Phase 1 Study of ALA-3000 [Phase 1]
Phase 1 multiple ascending dose study of ALA-3000 in treatment-resistant depression has completed.
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CLINICAL_TRIALS research · 2025-12-31Clinical Trial Update: CET- REM (Correlating ECT Response to EEG Markers) [NA]
The CET-REM study investigates whether EEG markers correlate with electroconvulsive therapy response in treatment-resistant depression, and …
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CLINICAL_TRIALS research · 2025-12-30Clinical Trial Update: Vagus Nerve Stimulation (VNS) Electroencephalogram (EEG) Protocol Supplement [NA]
This document provides a protocol supplement for a vagus nerve stimulation (VNS) study in treatment-resistant depression, outlining EEG meth…
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CLINICAL_TRIALS research · 2025-12-29Clinical Trial Update: Ketamine Biomarker Validation [Phase 1]
A Phase 1 trial from Soterix Medical is validating ketamine biomarkers for treatment-resistant depression and is not yet recruiting.
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CLINICAL_TRIALS trial_result · 2025-12-24Clinical Trial Update: The Safety and Efficacy of Psilocybin in Patients With Treatment-resistant Depression and Chronic Suicidal Ideation [Phase 2]
A Phase 2 clinical trial evaluating psilocybin for safety and efficacy in treatment-resistant depression with chronic suicidal ideation has …
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CLINICAL_TRIALS trial_result · 2025-12-23Clinical Trial Update: Brain Reactivity to Nitrous Oxyde in Depression : an MRI and Ultrasound Study (PROTOBRAIN Pilote) [NA]
A completed pilot study examining brain reactivity to nitrous oxide in treatment-resistant depression using MRI and ultrasound imaging.
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CLINICAL_TRIALS trial_result · 2025-12-18Clinical Trial Update: Efficacy, Safety, and Tolerability of COMP360 in Participants With TRD [Phase 3]
Clinical trial update on the Phase 3 study of COMP360 for treatment-resistant depression, highlighting efficacy, safety, and tolerability in…
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CLINICAL_TRIALS research · 2025-12-18Clinical Trial Update: Parcel-guided rTMS for Major Depressive Disorder [Phase 2]
Phase 2 clinical trial update on parcel-guided rTMS by Soterix Medical for major depressive disorder with treatment-resistant depression; th…
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CLINICAL_TRIALS research · 2025-12-17Clinical Trial Update: Feasibility Trial of Exercise as a Priming Strategy for rTMS Treatment in Difficult-to-Treat Depression [NA]
ClinicalTrials.gov update describing a feasibility study evaluating whether exercise can prime response to repetitive transcranial magnetic …
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CLINICAL_TRIALS research · 2025-12-10Clinical Trial Update: Sustained Mood Improvement With Laughing Gas Exposure [Phase 3]
A Phase 3 clinical trial sponsored by Women's College Hospital is investigating nitrous oxide exposure for sustained mood improvement in maj…
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: Comparison of the Efficacy of Accelerated Intermittent Theta Burst Stimulation and Accelerated Continuous Theta Burst Stimulation in Patients With Treatment-Resistant Depression [NA]
Status update for a clinical trial comparing accelerated intermittent theta burst stimulation and accelerated continuous theta burst stimula…
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CLINICAL_TRIALS research · 2025-11-28Clinical Trial Update: An Open-Label Study to Evaluate the Safety, Tolerability and Pharmacodynamics of BPL-003 in Patients With Treatment Resistant Depression [Phase 2]
Open-label Phase 2 study to evaluate the safety, tolerability, and pharmacodynamics of BPL-003 in patients with treatment-resistant depressi…
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CLINICAL_TRIALS research · 2025-11-26Clinical Trial Update: Psilocybin rTMS for Treatment Resistant Depression [Phase 2]
A Phase 2 clinical trial at the University of Texas at Austin is testing psilocybin-assisted rTMS for treatment-resistant depression and is …