Treatment-resistant Depression
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-03-23Clinical Trial Update: Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant Depression [Phase 1]
This Phase 1 trial investigates whether gamma oscillations can predict response to ketamine therapy in treatment-resistant depression. The s…
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CLINICAL_TRIALS research · 2026-03-20Clinical Trial Update: Psilocybin for Treatment-Resistant Depression in Autism [Phase 1]
Phase 1 clinical trial investigating psilocybin for treatment-resistant depression in individuals with autism spectrum disorder is currently…
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CLINICAL_TRIALS research · 2026-03-18Clinical Trial Update: Evaluating the Role of Psilocybin Monitors in Psilocybin Therapy for Treatment Resistant Depression [Phase 2]
A Phase 2 clinical trial update evaluating the role of psilocybin monitors in psilocybin-assisted therapy for treatment-resistant depression…
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CLINICAL_TRIALS trial_result · 2026-03-18Clinical Trial Update: Personalized Therapeutic Neuromodulation for Anhedonic Depression [NA]
This update reports the completion of a clinical trial investigating personalized neuromodulation for treatment-resistant depression.
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CLINICAL_TRIALS research · 2026-03-16Clinical Trial Update: ipRGC as a Potential Biomarker for Predicting Transcranial Magnetic Stimulation Treatment Response in Major Depressive Disorder [NA]
A clinical trial is evaluating intrinsically photosensitive retinal ganglion cells (ipRGCs) as a biomarker to predict response to transcrani…
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CLINICAL_TRIALS research · 2026-03-16Clinical Trial Update: InTRavenous kEtAmine and immerSive virtUal Reality to Treat dEpression [Phase 3]
Phase 3 trial update for intravenous ketamine combined with immersive virtual reality to treat treatment-resistant depression; the study is …
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CLINICAL_TRIALS research · 2026-03-16Clinical Trial Update: Characterizing Dopamine Receptor Binding in Treatment Resistant Depression
A clinical trial in recruitment to characterize dopamine receptor binding in patients with treatment-resistant depression.
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: Disruptions of Brain Networks and Sleep by Electroconvulsive Therapy
A clinical trial is examining how electroconvulsive therapy affects brain networks and sleep in individuals with treatment-resistant depress…
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CLINICAL_TRIALS trial_result · 2026-03-04Clinical Trial Update: Neurofeedback for Treatment Resistant Depression [NA]
A completed clinical trial evaluating neurofeedback as a treatment for treatment-resistant depression. The update does not include reported …
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CLINICAL_TRIALS withdrawal · 2026-03-04Clinical Trial Update: N2O for Acute Suicidality and Depression in the ED [Phase 2]
A Phase 2 clinical trial evaluating nitrous oxide for acute suicidality and major depressive disorder in the emergency department has been w…
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CLINICAL_TRIALS research · 2026-03-03Clinical Trial Update: 40 Hz Light Neurostimulation for Patients With Depression (FELIX) [NA]
Ongoing clinical trial evaluating 40 Hz light neurostimulation for adults with major depressive disorder and treatment-resistant depression.…
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CLINICAL_TRIALS research · 2026-03-03Clinical Trial Update: University of Iowa Interventional Psychiatry Service Patient Registry
This clinical trial registry entry from the University of Iowa Interventional Psychiatry Service is recruiting participants for a patient re…
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CLINICAL_TRIALS research · 2026-03-02Clinical Trial Update: Ultrasound Neuromodulation of Circuits and Negative Valence Systems in Treatment-Resistant Depression [NA]
A clinical trial from Laureate Institute for Brain Research is investigating ultrasound neuromodulation targeting brain circuits and negativ…
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: Virtual Reality-Based Mindfulness as an Adjunct to Treatment as Usual in Treatment-Resistant Depression [NA]
Clinical trial evaluating virtual reality-based mindfulness as an adjunct to treatment as usual for treatment-resistant depression. The stud…
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CLINICAL_TRIALS research · 2026-02-25Clinical Trial Update: Biomarker-guided rTMS for Treatment Resistant Depression [Phase 3]
Phase 3 clinical trial investigating biomarker-guided repetitive transcranial magnetic stimulation for treatment-resistant depression is cur…
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CLINICAL_TRIALS research · 2026-02-23Clinical Trial Update: Deep Brain Stimulation (DBS) Therapy for Treatment Resistant Depression [NA]
Clinical trial update on deep brain stimulation therapy for treatment-resistant depression, with status active but not recruiting.
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CLINICAL_TRIALS research · 2026-02-17Clinical Trial Update: DBS for TRD With the Medtronic Summit RC+S [NA]
This clinical trial update reports that a deep brain stimulation approach using the Medtronic Summit RC+S for treatment-resistant depression…
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CLINICAL_TRIALS research · 2026-02-12Clinical Trial Update: DBS for TRD With the Medtronic Percept PC [NA]
A clinical trial update shows recruitment is ongoing for a deep brain stimulation study using the Medtronic Percept PC to treat treatment-re…
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CLINICAL_TRIALS research · 2026-02-06Clinical Trial Update: Dopaminergic Dysfunction in Late-Life Depression [Phase 2]
A Phase 2 clinical trial from Vanderbilt University Medical Center is investigating dopaminergic dysfunction in late-life depression and its…
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CLINICAL_TRIALS research · 2026-02-05Clinical Trial Update: Ketogenic Diet and Neuromodulation in Treatment Resistant Depression [NA]
A Sunnybrook Health Sciences Centre trial is evaluating a ketogenic diet combined with neuromodulation for treatment-resistant major depress…
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CLINICAL_TRIALS research · 2026-02-04Clinical Trial Update: A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA) [Phase 2]
Phase 2 trial ongoing to evaluate the efficacy, safety, and tolerability of VLS-01 Buccal Film versus placebo in treatment-resistant depress…
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FDA approval · 2026-01-30FDA Approved: OLANZAPINE AND FLUOXETINE — Supplemental Application (Teva Pharmaceuticals USA, Inc.)
FDA approved Teva's supplemental application for a generic fixed-dose combination of olanzapine and fluoxetine, expanding access to this ant…
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FDA approval · 2026-01-30FDA Approved: OLANZAPINE AND FLUOXETINE — Supplemental Application (Par Health USA, LLC)
FDA approved a supplemental application for the olanzapine and fluoxetine combination (olanzapine + fluoxetine) submitted by Par Health USA,…
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CLINICAL_TRIALS trial_result · 2026-01-28Clinical Trial Update: Open-Label Safety Study of AXS-05 in Subjects With TRD (EVOLVE) [Phase 2]
An open-label Phase 2 safety study of AXS-05 in treatment-resistant depression and major depressive disorder was terminated, with results po…
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CLINICAL_TRIALS research · 2026-01-28Clinical Trial Update: Accelerated vs. Conventional Theta Burst Stimulation for Late-life Depression [NA]
A clinical trial is evaluating accelerated versus conventional theta burst stimulation for late-life depression and is currently recruiting.