Treatment-resistant Depression
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CLINICAL_TRIALS trial_result · 2026-07-29Clinical Trial Results: Personalized Therapeutic Neuromodulation for Anhedonic Depression [NA]
A completed clinical trial evaluating personalized therapeutic neuromodulation for treatment-resistant depression has posted results.
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CLINICAL_TRIALS trial_result · 2026-04-27Clinical Trial Update: Algorithm Guided Treatment Versus Treatment as Usual (TAU) for Patients With Treatment Resistant Depression [Phase 4]
Phase 4 clinical trial update evaluating algorithm-guided treatment versus treatment as usual for treatment resistant depression is currentl…
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CLINICAL_TRIALS trial_result · 2026-04-23Clinical Trial Update: Slow Wave Induction by Propofol to Eliminate Depression (SWIPED) I [Phase 1]
Phase 1 trial SWIP I tested whether slow-wave induction by propofol could treat treatment-resistant depression. The study has completed and …
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: Ketamine-Assisted Psychotherapy for Treatment-Resistant Depression [Phase 2]
A Phase 2 clinical trial investigating ketamine-assisted psychotherapy for treatment-resistant depression, including chronic pain as a condi…
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: Dasatinib Plus Quercetin for Accelerated Aging in Mental Disorders [Phase 2]
Phase 2 clinical trial update evaluating dasatinib plus quercetin for accelerated aging in schizophrenia and treatment-resistant depression;…
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CLINICAL_TRIALS trial_result · 2026-04-21Clinical Trial Update: Accelerated Theta Burst in Treatment-Resistant Depression: A Dose Finding and Biomarker Study [NA]
Results have been posted for a dose-finding and biomarker study evaluating accelerated theta burst stimulation in treatment-resistant depres…
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: Transcranial Photobiomodulation (tPBM) for Somatic Symptoms in Treatment-Resistant Depression [NA]
The document reports ongoing recruitment for a clinical trial using transcranial photobiomodulation to address somatic symptoms in treatment…
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CLINICAL_TRIALS trial_result · 2026-04-21Clinical Trial Update: Oral Aspirin + Ketamine as Adjunct to Oral Antidepressant Therapy for Depression [Phase 4]
Phase 4 clinical trial assessing oral aspirin plus ketamine as an adjunct to standard antidepressant therapy for treatment-resistant depress…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Improving Brain Stimulation Through Imaging
Clinical trial update describing research on improving brain stimulation through imaging for depression. The study includes treatment-resist…
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CLINICAL_TRIALS trial_result · 2026-04-17Clinical Trial Update: Phase 2 Study of NV-5138 in Adults With Treatment Resistant Depression [Phase 2]
Navitor Pharmaceuticals announced completion of the Phase 2 study of NV-5138 in adults with treatment-resistant depression, and the results …
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CLINICAL_TRIALS trial_result · 2026-04-17Clinical Trial Update: A Multiple Case Study of Schema Therapy for Difficult-to-treat Depression- DEPRE-ST*Case [NA]
A completed clinical trial using a multiple case study design to examine schema therapy for difficult-to-treat depression. The study status …
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response [Phase 2]
Phase 2 ACP-211 monotherapy for major depressive disorder is currently recruiting, including treatment-resistant cases. The sponsor is ACADI…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression [Phase 2]
Phase 2 clinical trial update investigating the antidepressant effects of 2R,6R-hydroxynorketamine (HNK) as a glutamate-release enhancer for…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND) [NA]
A clinical trial update indicating that Abbott Medical Devices is recruiting for TRANSCEND, a deep brain stimulation study targeting treatme…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: Early Brainwave Biomarkers for Personalized Neuromodulation in Treatment-resistant Depression [NA]
A clinical trial registry entry describing research on early brainwave biomarkers to guide personalized neuromodulation for treatment-resist…
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FDA approval · 2026-04-13FDA Approved: SPRAVATO — Supplemental Application (Janssen Pharmaceuticals Inc.)
FDA approved a supplemental application for SPRAVATO (esketamine hydrochloride) from Janssen Pharmaceuticals Inc.
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Belief Updating in Treatment Resistant Depression
An ongoing clinical trial (NCT05577247) sponsored by Assistance Publique - Hôpitaux de Paris is investigating belief updating in individuals…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: rTMS With and Without Text4Support for the Treatment of Resistant Depression. [NA]
A clinical trial update indicates recruiting for a study of repetitive transcranial magnetic stimulation (rTMS) with and without Text4Suppor…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: A Study of Esketamine Nasal Spray in Korean Participants With Treatment-resistant Depression [Phase 4]
Clinical trial update for Esketamine Nasal Spray in Korean participants with treatment-resistant depression, in Phase 4 and currently recrui…
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CLINICAL_TRIALS trial_result · 2026-04-09Clinical Trial Update: Adaptive tDCS for Treatment-Resistant MDD [Phase 1]
A Phase 1 adaptive transcranial direct current stimulation (tDCS) trial for treatment-resistant depression has been terminated.
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CLINICAL_TRIALS research · 2026-04-06Clinical Trial Update: Mindfulness Engaged Neurostimulation for Depression (MEND II) [Phase 2]
Phase 2 clinical trial evaluating Mindfulness Engaged Neurostimulation for Depression is not yet recruiting, studying treatment options for …
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CLINICAL_TRIALS trial_result · 2026-03-31Clinical Trial Update: Mindfulness Engaged Neurostimulation for Depression [Phase 2]
Phase 2 clinical trial of Mindfulness Engaged Neurostimulation for depression is currently active but not recruiting at University of Califo…
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CLINICAL_TRIALS trial_result · 2026-03-30Clinical Trial Update: KET-RO Plus RO DBT for Treatment Resistant Depression [Phase 1]
Phase 1 trial evaluating the combination of ketamine with RO-DBT for treatment-resistant depression has completed and posted results.
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: Psilocybin Assisted Psychotherapy for Treatment Resistant Depression and Co-occurring Substance Use Disorder [Phase 1, Phase 2]
This is a clinical trial update describing a psilocybin-assisted psychotherapy study for treatment-resistant depression with co-occurring su…
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CLINICAL_TRIALS trial_result · 2026-03-27Clinical Trial Update: Minocycline as Adjunctive Treatment for Treatment Resistant Depression [Phase 3]
A Phase 3 clinical trial evaluating minocycline as an adjunctive treatment for treatment-resistant depression has completed.