Thalassemia Major
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-04-28Clinical Trial Results: Pilot Study PBSCT With TCRab Depletion For Hemoglobinopathies [NA]
Pilot study results for peripheral blood stem cell transplantation with TCRab depletion in hemoglobinopathies were completed and results pos…
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CLINICAL_TRIALS research · 2026-02-11Clinical Trial Update: Growth Evaluation, Health Promotion, and Clinical Management in Children and Adolescents With Thalassemia [NA]
This trial investigates growth evaluation, health promotion, and clinical management in children and adolescents with thalassemia intermedia…
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CLINICAL_TRIALS trial_result · 2025-04-06Clinical Trial Update: Study to Evaluate the Long- Term Safety and Efficacy of Luspatercept in Subjects Who Received at Least One Dose of Luspatercept in the Compassionate Use Phase
Clinical trial update on the long-term safety and efficacy of luspatercept in subjects who received at least one dose during the compassiona…
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CLINICAL_TRIALS trial_result · 2025-04-02Clinical Trial Update: EDIT-301 for Autologous Hematopoietic Stem Cell Transplant (HSCT) in Participants With Transfusion-Dependent Beta Thalassemia (TDT) [Phase 1, Phase 2]
Editas Medicine reports an update for EDIT-301, an autologous hematopoietic stem cell gene-editing therapy, currently in Phase 1/Phase 2 for…
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CLINICAL_TRIALS trial_result · 2025-03-13Clinical Trial Update: To Evaluate Long- Term Safety and Efficacy of Luspatercept
An update on a long-term safety and efficacy study of luspatercept in thalassemia major; the trial is active but not currently recruiting.
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CLINICAL_TRIALS trial_result · 2024-08-09Clinical Trial Update: Hematopoietic Stem Cell Transplantation for Patients With Thalassemia Major: A Multicenter, Prospective Clinical Study [Phase 4]
A multicenter Phase 4 prospective study evaluating hematopoietic stem cell transplantation in patients with thalassemia major has been compl…
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CLINICAL_TRIALS research · 2024-06-24Clinical Trial Update: A Phase 1 Study of Gene-modified Autologous Hematopoietic Stem Cell (BD211) Treating β-thalassemia Major [Phase 1]
Phase 1 trial to evaluate gene-modified autologous hematopoietic stem cells (BD211) for treating β-thalassemia major is currently recruiting…
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CLINICAL_TRIALS trial_result · 2024-06-21Clinical Trial Update: Comparison of Deferasirox and Desferoxamine in Patients of β-Thalassemia Major With Iron Overload [NA]
A completed clinical trial comparing the iron chelators deferasirox and deferoxamine in patients with β-thalassemia major and iron overload.
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CLINICAL_TRIALS research · 2022-07-18Clinical Trial Update: The Safety and Efficiency of Luspatercept in Chinese Adults With Transfusion Dependent β-thalassemia: a Real-world Study [Phase 4]
Phase 4 real-world study assessing safety and efficacy of luspatercept in Chinese adults with transfusion-dependent thalassemia (beta-thalas…
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CLINICAL_TRIALS trial_result · 2022-02-01Clinical Trial Update: Pilot Study to Assess the Safety, PK and Iron Chelating Activity of DST-0509 (Deferasirox) in Thalassemia Patients Refractory to Chelation [Phase 2]
Phase 2 pilot trial assessing safety, pharmacokinetics, and iron chelating activity of DST-0509 (Deferasirox) in thalassemia major patients …
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CLINICAL_TRIALS trial_result · 2021-11-12Clinical Trial Update: Impact of the Preparation Method of Red Cell Concentrates on Transfusion Indices in Thalassemic Patients [Phase 4]
Phase 4 trial evaluating how the preparation method of red cell concentrates affects transfusion indices in patients with Thalassemia Major.
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CLINICAL_TRIALS trial_result · 2021-01-27Clinical Trial Update: Hydroxy Urea, Omega 3, Nigella Sativa,Honey on Oxidative Stress and Iron Chelation in Pediatric Major Thalassemia [Phase 2, Phase 3]
Phase 2/Phase 3 trial evaluating hydroxyurea, omega-3, Nigella sativa, and honey for iron overload and oxidative stress in pediatric major t…
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FDA approval · 2020-04-13FDA Approved: DEFERASIROX — Supplemental Application (Xiromed, LLC)
The FDA approved a supplemental application for deferasirox filed by Xiromed, LLC under an ANDA.
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CLINICAL_TRIALS trial_result · 2020-02-05Clinical Trial Update: Efficacy and Safety of Neridronate (Nerixia®)to Treat Osteoporosis in Patients With TM and TI [Phase 2]
Phase 2 trial update on neridronate (Nerixia) for osteoporosis in patients with thalassemia major/intermedia showing efficacy and safety res…
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CLINICAL_TRIALS trial_result · 2019-12-12Clinical Trial Update: Denosumab Versus Zoledronic Acid in Thalassemia-Induced Osteoporosis [Phase 3]
Phase 3 trial comparing denosumab to zoledronic acid in thalassemia-induced osteoporosis was terminated.
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CLINICAL_TRIALS trial_result · 2019-08-26Clinical Trial Update: Denosumab vs Placebo in Patients With Thalassemia Major and Osteoporosis [Phase 2]
Phase 2 trial comparing denosumab to placebo in patients with thalassemia major and osteoporosis has completed.
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CLINICAL_TRIALS trial_result · 2019-05-08Clinical Trial Update: A Study Evaluating the Safety and Efficacy of the LentiGlobin BB305 Drug Product in β-Thalassemia Major Participants [Phase 1, Phase 2]
Clinical trial update summarizes safety and efficacy findings for LentiGlobin BB305 in patients with β-thalassemia major across Phase 1/Phas…
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CLINICAL_TRIALS trial_result · 2019-02-06Clinical Trial Update: Pilot Study for Patients With Poor Response to Deferasirox [Phase 4]
Phase 4 pilot trial update on patients with poor response to Deferasirox.
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CLINICAL_TRIALS trial_result · 2018-07-18Clinical Trial Update: Study to Evaluate Efficacy and Safety of S303 Treated Red Blood Cells (RBCs)in Subjects With Thalassemia Major Requiring Chronic RBC Transfusion [Phase 3]
Phase 3 trial evaluating the efficacy and safety of S303-treated red blood cells in subjects with thalassemia major requiring chronic transf…
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CLINICAL_TRIALS trial_result · 2017-10-18Clinical Trial Update: Periodontal Therapy in Thalassemia Major Patients [NA]
King Saud University sponsored a clinical trial evaluating periodontal therapy in patients with thalassemia major and chronic periodontitis.…
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CLINICAL_TRIALS trial_result · 2017-06-15Clinical Trial Update: Study of Efficacy and Safety of INC424 in Regularly Transfused Patients With Thalassemia. [Phase 2]
A Phase 2 study of INC424 in regularly transfused patients with thalassemia major has completed, with results posted in 2017 evaluating effi…
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CLINICAL_TRIALS other · 2017-05-31Clinical Trial Update: Haploidentical Hematopoietic Stem Cell Transplantation for Patients With Thalassemia Major [Phase 4]
A Phase 4 clinical trial update on haploidentical hematopoietic stem cell transplantation for patients with thalassemia major; the registry …
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CLINICAL_TRIALS trial_result · 2017-04-17Clinical Trial Update: Zinc Supplementation on Cellular Immunity in Thalassemia Major [Phase 4]
Phase 4 study evaluating zinc supplementation on cellular immunity in thalassemia major has completed.
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CLINICAL_TRIALS trial_result · 2017-03-29Clinical Trial Update: Pneumococcal Vaccination for Splenectomised Thalassemia Major Patients in Indonesia [Phase 4]
A Phase 4 clinical trial in Indonesia completed evaluating pneumococcal vaccination in splenectomised thalassemia major patients.
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CLINICAL_TRIALS trial_result · 2016-09-21Clinical Trial Update: High-Tc Susceptometer to Monitor Transfusional Iron Overload
Clinical trial update reporting that the study evaluating a High-Tc Susceptometer to monitor transfusional iron overload has completed, in p…