Synovial Sarcoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-04-16Clinical Trial Update: Phase I/Ib Study of NK Expressing an Affinity-enhanced T-cell Receptor (TCR) Against the NY-ESO-1 [Phase 1]
Phase 1/1b clinical trial evaluating NK cells engineered to express an affinity-enhanced T-cell receptor targeting NY-ESO-1 in patients with…
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CLINICAL_TRIALS trial_result · 2026-04-13Clinical Trial Update: Testing Low-Dose Common Chemotherapy (Liposomal Doxorubicin) in Combination With an Anti-Cancer Drug, Peposertib, in Advanced Sarcoma [Phase 1]
Phase 1 trial evaluating the safety of low-dose pegylated liposomal doxorubicin in combination with peposertib for advanced sarcoma; current…
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CLINICAL_TRIALS trial_result · 2026-04-08Clinical Trial Update: Study to Evaluate Safety and Antitumor Activity of Lete-Cel (GSK3377794) in HLA-A2+ Participants With NY-ESO-1 Positive Previously Treated Advanced (Metastatic or Unresectable) Synovial Sarcoma or Myxoid/Round Cell Liposarcoma [Phase 2]
Phase 2 clinical trial evaluating the safety and antitumor activity of Lete-Cel (GSK3377794) in HLA-A2+ patients with NY-ESO-1 positive syno…
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CLINICAL_TRIALS trial_result · 2026-03-06Clinical Trial Update: Prospective Identification of Predictive Biomarkers of Trabectedin Efficacy in Non-L Soft-tissue Sarcoma Patients [NA]
Trial update reporting prospective identification of predictive biomarkers for trabectedin efficacy across non-liposarcoma soft tissue sarco…
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CLINICAL_TRIALS trial_result · 2025-12-03Clinical Trial Update: N-803 in Patients With Progressive Synovial Sarcoma and Myxoid/Round Cell Liposarcoma Previously Treated With Adoptive Cellular Therapy [EARLY_Phase 1]
A Phase 1 trial update on N-803 for patients with progressive synovial sarcoma and myxoid/round cell liposarcoma who previously received ado…
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CLINICAL_TRIALS trial_result · 2025-11-04Clinical Trial Update: A Study to Assess Long-term Safety of Tazemetostat in Adult Participants of All Ages With Any Disease Treated With Tazemetostat in a Previous Clinical Study [Phase 1, Phase 2]
This document reports the completion of a long-term safety study of tazemetostat in adults who previously received the drug in earlier trial…
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CLINICAL_TRIALS trial_result · 2025-09-05Clinical Trial Update: START: Safety and Anti-Tumor Activity of PeptiCRAd-1 in Treatment of Cancer [Phase 1]
Phase 1 trial update of PeptiCRAd-1 reports safety signals and anti-tumor activity across multiple cancers; trial status is ACTIVE_NOT_RECRU…
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CLINICAL_TRIALS trial_result · 2025-03-11Clinical Trial Update: A Study of Tazemetostat in Adult Participants With Soft Tissue Sarcoma [Phase 2]
Phase 2 study of tazemetostat in adult participants with soft tissue sarcoma, including rhabdoid tumors, has completed and results were post…
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CLINICAL_TRIALS trial_result · 2025-01-13Clinical Trial Update: Spearhead 1 Study in Subjects With Advanced Synovial Sarcoma or Myxoid/Round Cell Liposarcoma [Phase 2]
Spearhead 1, a Phase 2 trial in advanced synovial sarcoma or myxoid/round cell liposarcoma, has posted results; the study is currently activ…
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CLINICAL_TRIALS trial_result · 2024-12-17Clinical Trial Update: A Study to Assess the Safety and Tolerability of CFT8634 in Locally Advanced or Metastatic SMARCB1-Perturbed Cancers, Including Synovial Sarcoma and SMARCB1-Null Tumors [Phase 1]
A Phase 1 study evaluating the safety and tolerability of CFT8634 in SMARCB1-perturbed cancers, including Synovial Sarcoma and SMARCB1-null …
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CLINICAL_TRIALS trial_result · 2024-11-20Clinical Trial Update: Study of TBI-1301 (NY-ESO-1 T Cell Receptor Gene Transduced Autologous T Lymphocytes) in Patients with Synovial Sarcoma [Phase 1, Phase 2]
Completed Phase 1/2 clinical trial evaluating TBI-1301, an NY-ESO-1 TCR gene-transduced autologous T cell therapy, in patients with synovial…
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CLINICAL_TRIALS trial_result · 2024-10-03Clinical Trial Update: EZH2 Inhibitor Tazemetostat in Pediatric Subjects With Relapsed or Refractory INI1-Negative Tumors or Synovial Sarcoma [Phase 1]
Phase 1 pediatric trial of the EZH2 inhibitor tazemetostat in INI1-negative tumors and synovial sarcoma has completed. Results have been pos…
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: Phase 1, First-in-human Study of Oral TP-1287 in Patients with Advanced Solid Tumors [Phase 1]
Phase 1 first-in-human study of oral TP-1287 in patients with advanced solid tumors, including specific sarcoma subtypes, has been terminate…
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CLINICAL_TRIALS trial_result · 2024-08-26Clinical Trial Update: Effects of Itraconazole and Rifampin on the Blood Tazemetostat Levels [Phase 1]
Phase 1 trial assessing the pharmacokinetic interactions of itraconazole and rifampin with tazemetostat; results published for patients with…
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CLINICAL_TRIALS trial_result · 2024-05-10Clinical Trial Update: Study of GSK3901961 In Previously Treated Advanced (Metastatic OR Unresectable) Synovial Sarcoma/ Myxoid/Round Cell Liposarcoma, and Previously Treated Metastatic Non-Small Cell Lung Cancer [Phase 1]
A Phase 1 study of GSK3901961 in previously treated synovial sarcoma, myxoid/round cell liposarcoma, and metastatic non-small cell lung canc…
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CLINICAL_TRIALS trial_result · 2024-05-08Clinical Trial Update: Itacitinib in Treating Patients With Refractory Metastatic/Advanced Sarcomas [Phase 1]
Itacitinib was studied in a Phase 1 trial for patients with refractory metastatic/advanced sarcomas, but the study status is TERMINATED.
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CLINICAL_TRIALS trial_result · 2024-03-18Clinical Trial Update: Study of GSK3845097 in Previously Treated Participants With Advanced Synovial Sarcoma and Myxoid/Round Cell Liposarcoma [Phase 1]
A Phase 1 study evaluating GSK3845097 in previously treated patients with advanced synovial sarcoma and myxoid/round cell liposarcoma was te…
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CLINICAL_TRIALS trial_result · 2023-11-07Clinical Trial Update: Doxorubicin With Upfront Dexrazoxane for the Treatment of Advanced or Metastatic Soft Tissue Sarcoma [Phase 2]
Phase 2 trial evaluating doxorubicin with upfront dexrazoxane for advanced or metastatic soft tissue sarcoma has completed enrollment with r…
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CLINICAL_TRIALS trial_result · 2023-10-16Clinical Trial Update: Study to Evaluate Safety and Antitumor Activity of Lete-Cel (GSK3377794) in HLA-A2+ Participants With NY-ESO-1 Positive Previously Untreated Advanced (Metastatic or Unresectable) Synovial Sarcoma and Myxoid/Round Cell Liposarcoma [Phase 2]
Phase 2 study evaluating safety and antitumor activity of Lete-Cel (GSK3377794) in HLA-A2+ patients with NY-ESO-1 positive, previously untre…
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CLINICAL_TRIALS trial_result · 2023-09-13Clinical Trial Update: CAMPFIRE: A Study of Ramucirumab (LY3009806) in Children and Young Adults With Synovial Sarcoma [Phase 1, Phase 2]
A Phase 1/2 study of ramucirumab (LY3009806) in children and young adults with synovial sarcoma was terminated; results were posted in 2023.
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CLINICAL_TRIALS trial_result · 2022-08-30Clinical Trial Update: Testing the Combination of Two Experimental Drugs MK-3475 (Pembrolizumab) and Interferon-gamma for the Treatment of Mycosis Fungoides and Sézary Syndrome and Advanced Synovial Sarcoma [Phase 2]
Phase 2 trial updates the combination of pembrolizumab and interferon-gamma for various mycosis fungoides/Sezary syndrome and synovial sarco…
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CLINICAL_TRIALS trial_result · 2022-05-31Clinical Trial Update: Gene-Modified T Cells With or Without Decitabine in Treating Patients With Advanced Malignancies Expressing NY-ESO-1 [Phase 1, Phase 2]
Phase 1/2 trial evaluating NY-ESO-1–targeted T-cell therapy with or without decitabine in patients with NY-ESO-1–expressing advanced cancers…
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CLINICAL_TRIALS trial_result · 2021-07-14Clinical Trial Update: A Study of Anti-CTLA-4 Antibody in Patients With Advanced Synovial Sarcoma [Phase 2]
Phase 2 trial of an anti-CTLA-4 antibody in advanced synovial sarcoma was terminated with results posted in 2021.
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CLINICAL_TRIALS trial_result · 2021-06-29Clinical Trial Update: Whole Lung IMRT in Children and Adults With Synovial Sarcoma and Lung Metastases [Phase 2]
Phase 2 trial investigating whole lung IMRT for synovial sarcoma with lung metastases; study completed with results posted in 2021.
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CLINICAL_TRIALS trial_result · 2020-07-09Clinical Trial Update: A Pilot Study of Genetically Engineered NY-ESO-1 Specific NY-ESO-1ᶜ²⁵⁹T in HLA-A2+ Patients With Synovial Sarcoma [Phase 1]
Phase 1 pilot study of a genetically engineered NY-ESO-1–targeted therapy in HLA-A2+ patients with synovial sarcoma has completed; results p…