A Phase I/IIa Study of TGFß Blockade in TCR-Engineered T-Cell Cancer Immunotherapy in Patients With Advanced Malignancies

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Record identity and dates

Source

ClinicalTrials.gov

Source record ID

NCT02650986

Title field or adapter rule

protocolSection.identificationModule.officialTitle

Ingested At

2026-04-25T22:27:40.800005+00:00

Published At

2022-05-31T00:00:00+00:00

Record Updated At

2025-06-17

Results Posted At

2022-05-31

Timestamp Basis

source retrieval time was not retained by the feed adapter

Date limitation

source retrieval time was not retained by the feed adapter

Fields recorded by this source

protocolSection.conditionsModule.conditions

["Advanced Fallopian Tube Carcinoma", "Advanced Malignant Solid Neoplasm", "Advanced Melanoma", "Advanced Ovarian Carcinoma", "Advanced Primary Peritoneal Carcinoma", "Advanced Synovial Sarcoma", "Clinical Stage III Cutaneous Melanoma AJCC v8", "Clinical Stage IV Cutaneous Melanoma AJCC v8", "Metastatic Fallopian Tube Carcinoma", "Metastatic Melanoma", "Metastatic Ovarian Carcinoma", "Metastatic Primary Peritoneal Carcinoma", "Metastatic Synovial Sarcoma", "Pathologic Stage III Cutaneous Melanoma AJCC v8", "Pathologic Stage IIIA Cutaneous Melanoma AJCC v8", "Pathologic Stage IIIB Cutaneous Melanoma AJCC v8", "Pathologic Stage IIIC Cutaneous Melanoma AJCC v8", "Pathologic Stage IIID Cutaneous Melanoma AJCC v8", "Pathologic Stage IV Cutaneous Melanoma AJCC v8", "Platinum-Resistant Fallopian Tube Carcinoma", "Platinum-Resistant Ovarian Carcinoma", "Platinum-Resistant Primary Peritoneal Carcinoma", "Stage III Fallopian Tube Cancer AJCC v8", "Stage III Ovarian Cancer AJCC v8", "Stage III Primary Peritoneal Cancer AJCC v8", "Stage IIIA Fallopian Tube Cancer AJCC v8", "Stage IIIA Ovarian Cancer AJCC v8", "Stage IIIA Primary Peritoneal Cancer AJCC v8", "Stage IIIA1 Fallopian Tube Cancer AJCC v8", "Stage IIIA1 Ovarian Cancer AJCC v8", "Stage IIIA2 Fallopian Tube Cancer AJCC v8", "Stage IIIA2 Ovarian Cancer AJCC v8", "Stage IIIB Fallopian Tube Cancer AJCC v8", "Stage IIIB Ovarian Cancer AJCC v8", "Stage IIIB Primary Peritoneal Cancer AJCC v8", "Stage IIIC Fallopian Tube Cancer AJCC v8", "Stage IIIC Ovarian Cancer AJCC v8", "Stage IIIC Primary Peritoneal Cancer AJCC v8", "Stage IV Fallopian Tube Cancer AJCC v8", "Stage IV Ovarian Cancer AJCC v8", "Stage IV Primary Peritoneal Cancer AJCC v8", "Stage IVA Fallopian Tube Cancer AJCC v8", "Stage IVA Ovarian Cancer AJCC v8", "Stage IVA Primary Peritoneal Cancer AJCC v8", "Stage IVB Fallopian Tube Cancer AJCC v8", "Stage IVB Ovarian Cancer AJCC v8", "Stage IVB Primary Peritoneal Cancer AJCC v8", "Unresectable Melanoma", "Unresectable Ovarian Carcinoma", "Unresectable Synovial Sarcoma"]

protocolSection.statusModule.lastUpdatePostDateStruct.date

"2025-06-17"

protocolSection.identificationModule.nctId

"NCT02650986"

protocolSection.identificationModule.officialTitle

"A Phase I/IIa Study of TGF\u00df Blockade in TCR-Engineered T-Cell Cancer Immunotherapy in Patients With Advanced Malignancies"

protocolSection.statusModule.overallStatus

"ACTIVE_NOT_RECRUITING"

protocolSection.designModule.phases

["PHASE1", "PHASE2"]

protocolSection.statusModule.resultsFirstPostDateStruct.date

"2022-05-31"

Study condition terms

• Advanced Fallopian Tube Carcinoma (protocolSection.conditionsModule.conditions)
• Advanced Malignant Solid Neoplasm (protocolSection.conditionsModule.conditions)
• Advanced Melanoma (protocolSection.conditionsModule.conditions)
• Advanced Ovarian Carcinoma (protocolSection.conditionsModule.conditions)
• Advanced Primary Peritoneal Carcinoma (protocolSection.conditionsModule.conditions)
• Advanced Synovial Sarcoma (protocolSection.conditionsModule.conditions)
• Clinical Stage III Cutaneous Melanoma AJCC v8 (protocolSection.conditionsModule.conditions)
• Clinical Stage IV Cutaneous Melanoma AJCC v8 (protocolSection.conditionsModule.conditions)
• Metastatic Fallopian Tube Carcinoma (protocolSection.conditionsModule.conditions)
• Metastatic Melanoma (protocolSection.conditionsModule.conditions)
• Metastatic Ovarian Carcinoma (protocolSection.conditionsModule.conditions)
• Metastatic Primary Peritoneal Carcinoma (protocolSection.conditionsModule.conditions)
• Metastatic Synovial Sarcoma (protocolSection.conditionsModule.conditions)
• Pathologic Stage III Cutaneous Melanoma AJCC v8 (protocolSection.conditionsModule.conditions)
• Pathologic Stage IIIA Cutaneous Melanoma AJCC v8 (protocolSection.conditionsModule.conditions)
• Pathologic Stage IIIB Cutaneous Melanoma AJCC v8 (protocolSection.conditionsModule.conditions)
• Pathologic Stage IIIC Cutaneous Melanoma AJCC v8 (protocolSection.conditionsModule.conditions)
• Pathologic Stage IIID Cutaneous Melanoma AJCC v8 (protocolSection.conditionsModule.conditions)
• Pathologic Stage IV Cutaneous Melanoma AJCC v8 (protocolSection.conditionsModule.conditions)
• Platinum-Resistant Fallopian Tube Carcinoma (protocolSection.conditionsModule.conditions)
• Platinum-Resistant Ovarian Carcinoma (protocolSection.conditionsModule.conditions)
• Platinum-Resistant Primary Peritoneal Carcinoma (protocolSection.conditionsModule.conditions)
• Stage III Fallopian Tube Cancer AJCC v8 (protocolSection.conditionsModule.conditions)
• Stage III Ovarian Cancer AJCC v8 (protocolSection.conditionsModule.conditions)
• Stage III Primary Peritoneal Cancer AJCC v8 (protocolSection.conditionsModule.conditions)
• Stage IIIA Fallopian Tube Cancer AJCC v8 (protocolSection.conditionsModule.conditions)
• Stage IIIA Ovarian Cancer AJCC v8 (protocolSection.conditionsModule.conditions)
• Stage IIIA Primary Peritoneal Cancer AJCC v8 (protocolSection.conditionsModule.conditions)
• Stage IIIA1 Fallopian Tube Cancer AJCC v8 (protocolSection.conditionsModule.conditions)
• Stage IIIA1 Ovarian Cancer AJCC v8 (protocolSection.conditionsModule.conditions)
• Stage IIIA2 Fallopian Tube Cancer AJCC v8 (protocolSection.conditionsModule.conditions)
• Stage IIIA2 Ovarian Cancer AJCC v8 (protocolSection.conditionsModule.conditions)
• Stage IIIB Fallopian Tube Cancer AJCC v8 (protocolSection.conditionsModule.conditions)
• Stage IIIB Ovarian Cancer AJCC v8 (protocolSection.conditionsModule.conditions)
• Stage IIIB Primary Peritoneal Cancer AJCC v8 (protocolSection.conditionsModule.conditions)
• Stage IIIC Fallopian Tube Cancer AJCC v8 (protocolSection.conditionsModule.conditions)
• Stage IIIC Ovarian Cancer AJCC v8 (protocolSection.conditionsModule.conditions)
• Stage IIIC Primary Peritoneal Cancer AJCC v8 (protocolSection.conditionsModule.conditions)
• Stage IV Fallopian Tube Cancer AJCC v8 (protocolSection.conditionsModule.conditions)
• Stage IV Ovarian Cancer AJCC v8 (protocolSection.conditionsModule.conditions)
• Stage IV Primary Peritoneal Cancer AJCC v8 (protocolSection.conditionsModule.conditions)
• Stage IVA Fallopian Tube Cancer AJCC v8 (protocolSection.conditionsModule.conditions)
• Stage IVA Ovarian Cancer AJCC v8 (protocolSection.conditionsModule.conditions)
• Stage IVA Primary Peritoneal Cancer AJCC v8 (protocolSection.conditionsModule.conditions)
• Stage IVB Fallopian Tube Cancer AJCC v8 (protocolSection.conditionsModule.conditions)
• Stage IVB Ovarian Cancer AJCC v8 (protocolSection.conditionsModule.conditions)
• Stage IVB Primary Peritoneal Cancer AJCC v8 (protocolSection.conditionsModule.conditions)
• Unresectable Melanoma (protocolSection.conditionsModule.conditions)
• Unresectable Ovarian Carcinoma (protocolSection.conditionsModule.conditions)
• Unresectable Synovial Sarcoma (protocolSection.conditionsModule.conditions)

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