Synovial Sarcoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Evaluation for NCI Surgery Branch Clinical Research Protocols
NCI's Surgery Branch Clinical Research Protocols are currently recruiting for multiple cancer studies, including synovial sarcoma, melanoma,…
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CLINICAL_TRIALS trial_result · 2026-04-16Clinical Trial Update: Phase I/Ib Study of NK Expressing an Affinity-enhanced T-cell Receptor (TCR) Against the NY-ESO-1 [Phase 1]
Phase 1/1b clinical trial evaluating NK cells engineered to express an affinity-enhanced T-cell receptor targeting NY-ESO-1 in patients with…
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CLINICAL_TRIALS trial_result · 2026-04-13Clinical Trial Update: Testing Low-Dose Common Chemotherapy (Liposomal Doxorubicin) in Combination With an Anti-Cancer Drug, Peposertib, in Advanced Sarcoma [Phase 1]
Phase 1 trial evaluating the safety of low-dose pegylated liposomal doxorubicin in combination with peposertib for advanced sarcoma; current…
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CLINICAL_TRIALS trial_result · 2026-04-08Clinical Trial Update: Study to Evaluate Safety and Antitumor Activity of Lete-Cel (GSK3377794) in HLA-A2+ Participants With NY-ESO-1 Positive Previously Treated Advanced (Metastatic or Unresectable) Synovial Sarcoma or Myxoid/Round Cell Liposarcoma [Phase 2]
Phase 2 clinical trial evaluating the safety and antitumor activity of Lete-Cel (GSK3377794) in HLA-A2+ patients with NY-ESO-1 positive syno…
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: Alpha/Beta T and B Cell Depletion With Zoledronic Acid for Solid Tumors [Phase 1, Phase 2]
Phase 1/2 clinical trial evaluating alpha/beta T and B cell depletion with zoledronic acid for solid tumors; recruitment is ongoing.
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CLINICAL_TRIALS research · 2026-03-10Clinical Trial Update: Nivolumab and BO-112 Before Surgery for the Treatment of Resectable Soft Tissue Sarcoma [Phase 1]
Phase 1 trial evaluating nivolumab plus BO-112 as a neoadjuvant treatment before surgery for resectable soft tissue sarcoma, including multi…
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CLINICAL_TRIALS trial_result · 2026-03-06Clinical Trial Update: Prospective Identification of Predictive Biomarkers of Trabectedin Efficacy in Non-L Soft-tissue Sarcoma Patients [NA]
Trial update reporting prospective identification of predictive biomarkers for trabectedin efficacy across non-liposarcoma soft tissue sarco…
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CLINICAL_TRIALS research · 2026-02-25Clinical Trial Update: Phase III Trial of Anlotinib, Catequentinib in Advanced Alveolar Soft Part Sarcoma, Leiomyosarcoma, Synovial Sarcoma (APROMISS) [Phase 3]
APROMISS is a Phase III trial of combined anlotinib and catequentinib in advanced alveolar soft-part sarcoma, leiomyosarcoma, and synovial s…
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CLINICAL_TRIALS research · 2026-02-25Clinical Trial Update: Precision Medicine Approaches for Neoadjuvant Therapy in High-risk Sarcoma Patients
Clinical trial update describing precision medicine approaches for neoadjuvant therapy in high‑risk sarcoma patients; currently recruiting.
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CLINICAL_TRIALS research · 2026-02-18Clinical Trial Update: Multi-center Study of TBI-1301 (INN: Mipetresgene Autoleucel; Mip-cel) in Patients With NY-ESO-1 Positive Synovial Sarcoma [Phase 3]
A Phase 3 multi-center trial evaluating Mipetresgene Autoleucel (Mip-cel) for NY-ESO-1 positive synovial sarcoma is currently recruiting.
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CLINICAL_TRIALS research · 2026-02-09Clinical Trial Update: Expanded Access Protocol (EAP) for Nonconforming (NC) Afami-cel
Expanded Access Protocol (EAP) for nonconforming Afami-cel is available for patients with synovial sarcoma or myxoid liposarcoma.
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CLINICAL_TRIALS research · 2026-02-09Clinical Trial Update: SPEARHEAD-3 Pediatric Study [Phase 1, Phase 2]
SPEARHEAD-3 is a pediatric study enrolling in Phase 1 and Phase 2 across multiple cancers, including synovial sarcoma, malignant peripheral …
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CLINICAL_TRIALS research · 2026-01-28Clinical Trial Update: Dose-escalated, Hypofractionated, Definitive Proton Radiotherapy for Patients With Inoperable Soft Tissue Sarcoma. [Phase 2]
Clinical trial evaluating dose-escalated, hypofractionated definitive proton radiotherapy for patients with inoperable soft tissue sarcoma (…
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CLINICAL_TRIALS research · 2026-01-28Clinical Trial Update: Hypofractionated, 3-week, Preoperative Proton or X-ray Radiotherapy for Patients With Localized Soft Tissue Sarcoma [Phase 2]
Phase 2 clinical trial update evaluating hypofractionated, 3-week preoperative radiotherapy using proton or photon therapy for localized sof…
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CLINICAL_TRIALS research · 2026-01-22Clinical Trial Update: HER2 Chimeric Antigen Receptor (CAR) T Cells in Combination With Checkpoint Blockade in Patients With Advanced Sarcoma [Phase 1]
Phase 1 clinical trial evaluating HER2-targeted CAR T cells in combination with checkpoint blockade for advanced sarcoma; recruitment is ong…
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CLINICAL_TRIALS research · 2026-01-08Clinical Trial Update: ACTengine® IMA203 Combined With mRNA-4203 [Phase 1]
Phase 1 clinical trial update indicating ACTengine IMA203 in combination with mRNA-4203 is in early-stage testing for melanoma of the skin a…
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CLINICAL_TRIALS research · 2025-12-03Clinical Trial Update: Study of TBI-1301 (NY-ESO-1 Specific TCR Gene Transduced Autologous T Lymphocytes) in Patients With Solid Tumors [Phase 1]
Phase 1 study of TBI-1301, an NY-ESO-1–specific TCR gene-transduced autologous T cell therapy, in solid tumors; the trial is currently activ…
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CLINICAL_TRIALS trial_result · 2025-12-03Clinical Trial Update: N-803 in Patients With Progressive Synovial Sarcoma and Myxoid/Round Cell Liposarcoma Previously Treated With Adoptive Cellular Therapy [EARLY_Phase 1]
A Phase 1 trial update on N-803 for patients with progressive synovial sarcoma and myxoid/round cell liposarcoma who previously received ado…
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CLINICAL_TRIALS trial_result · 2025-11-04Clinical Trial Update: A Study to Assess Long-term Safety of Tazemetostat in Adult Participants of All Ages With Any Disease Treated With Tazemetostat in a Previous Clinical Study [Phase 1, Phase 2]
This document reports the completion of a long-term safety study of tazemetostat in adults who previously received the drug in earlier trial…
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CLINICAL_TRIALS research · 2025-10-02Clinical Trial Update: Anti-NY-ESO-1 TCR-Gene Engineered Lymphocytes Given by Infusion to Patients With NY-ESO-1 -Expressing Metastatic Cancers [Phase 1, Phase 2]
A Phase 1/Phase 2 clinical trial is evaluating infusion of NY-ESO-1–specific TCR-engineered lymphocytes in patients with NY-ESO-1-expressing…
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CLINICAL_TRIALS research · 2025-09-18Clinical Trial Update: AOH1996 for the Treatment of Refractory Solid Tumors [Phase 1]
AOH1996 is being studied in a Phase 1 trial for patients with refractory solid tumors, including osteosarcoma and several other sarcomas and…
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CLINICAL_TRIALS trial_result · 2025-09-05Clinical Trial Update: START: Safety and Anti-Tumor Activity of PeptiCRAd-1 in Treatment of Cancer [Phase 1]
Phase 1 trial update of PeptiCRAd-1 reports safety signals and anti-tumor activity across multiple cancers; trial status is ACTIVE_NOT_RECRU…
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CLINICAL_TRIALS research · 2025-07-24Clinical Trial Update: MASCT-I Combined With Doxorubicin and Ifosfamide for First-line Treatment of Advanced Soft Tissue Sarcoma [Phase 2]
A Phase 2 trial evaluating MASCT-I in combination with doxorubicin and ifosfamide as first-line therapy for advanced soft tissue sarcoma is …
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CLINICAL_TRIALS research · 2025-07-15Clinical Trial Update: Sequential Infusion of CD146-Targeted and HER2-Targeted CAR T Cells in Patients With Advanced Sarcomas [Phase 1, Phase 2]
A clinical trial update describing a Phase 1/2 study of sequential infusion of CD146-targeted and HER2-targeted CAR T cells in patients with…
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CLINICAL_TRIALS research · 2025-06-04Clinical Trial Update: Synovial Sarcoma Registry / Biospecimen Repository
This entry reports a synovial sarcoma registry and biospecimen repository study sponsored by Children's Hospital of Philadelphia, which is c…